Genular: Defining Cellular Identity and Function

Details for: Slc1a1

Gene ID: 20510

Symbol: Slc1a1

Ensembl ID: ENSMUSG00000024935

Description: solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1

Associated with

Glutamate neurotransmitter release cycle
(R-MMU-210500)
Neuronal system
(R-MMU-112316)
Neurotransmitter release cycle
(R-MMU-112310)
Slc-mediated transmembrane transport
(R-MMU-425407)
Transmission across chemical synapses
(R-MMU-112315)
Transport of inorganic cations/anions and amino acids/oligopeptides
(R-MMU-425393)
Transport of small molecules
(R-MMU-382551)
Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Activation of protein kinase b activity
(GO:0032148)
Adult behavior
(GO:0030534)
Amino acid transport
(GO:0006865)
Behavioral fear response
(GO:0001662)
Blood vessel morphogenesis
(GO:0048514)
Brain development
(GO:0007420)
Cellular response to ammonium ion
(GO:0071242)
Cellular response to cocaine
(GO:0071314)
Cellular response to mercury ion
(GO:0071288)
Cellular response to organic cyclic compound
(GO:0071407)
Cellular response to oxidative stress
(GO:0034599)
Chloride transmembrane transport
(GO:1902476)
Chloride transmembrane transporter activity
(GO:0015108)
Cysteine transmembrane transporter activity
(GO:0033229)
Cysteine transport
(GO:0042883)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine production
(GO:0001816)
D-aspartate import across plasma membrane
(GO:0070779)
D-aspartate transmembrane transporter activity
(GO:0140010)
D-aspartate transport
(GO:0070777)
Dopamine metabolic process
(GO:0042417)
Dopamine receptor signaling pathway
(GO:0007212)
Establishment of protein localization
(GO:0045184)
Gene expression
(GO:0010467)
Glutamate:sodium symporter activity
(GO:0015501)
Glutamate binding
(GO:0016595)
Glutamate receptor signaling pathway
(GO:0007215)
Glutathione biosynthetic process
(GO:0006750)
Glutathione metabolic process
(GO:0006749)
Grooming behavior
(GO:0007625)
Heart contraction
(GO:0060047)
High-affinity l-glutamate transmembrane transporter activity
(GO:0005314)
Identical protein binding
(GO:0042802)
Intracellular glutamate homeostasis
(GO:0090461)
Intracellular zinc ion homeostasis
(GO:0006882)
L-aspartate import across plasma membrane
(GO:0140009)
L-aspartate transmembrane transport
(GO:0070778)
L-aspartate transmembrane transporter activity
(GO:0015183)
L-glutamate import
(GO:0051938)
L-glutamate import across plasma membrane
(GO:0098712)
L-glutamate transmembrane transport
(GO:0015813)
L-glutamate transmembrane transporter activity
(GO:0005313)
Learning or memory
(GO:0007611)
Locomotory behavior
(GO:0007626)
Long-term synaptic potentiation
(GO:0060291)
Maintenance of blood-brain barrier
(GO:0035633)
Memory
(GO:0007613)
Metal ion binding
(GO:0046872)
Monoatomic anion channel activity
(GO:0005253)
Motor behavior
(GO:0061744)
Motor neuron apoptotic process
(GO:0097049)
Negative regulation of neuron apoptotic process
(GO:0043524)
Neurogenesis
(GO:0022008)
Neuron apoptotic process
(GO:0051402)
Neurotransmitter receptor transport to plasma membrane
(GO:0098877)
Peptidyl-serine phosphorylation
(GO:0018105)
Positive regulation of heart rate
(GO:0010460)
Postsynaptic modulation of chemical synaptic transmission
(GO:0099170)
Protein binding
(GO:0005515)
Regulation of heart rate
(GO:0002027)
Regulation of protein phosphorylation
(GO:0001932)
Regulation of protein targeting to membrane
(GO:0090313)
Response to amphetamine
(GO:0001975)
Response to anesthetic
(GO:0072347)
Response to axon injury
(GO:0048678)
Response to decreased oxygen levels
(GO:0036293)
Response to morphine
(GO:0043278)
Response to xenobiotic stimulus
(GO:0009410)
Retina development in camera-type eye
(GO:0060041)
Retina layer formation
(GO:0010842)
Righting reflex
(GO:0060013)
Superoxide metabolic process
(GO:0006801)
Symporter activity
(GO:0015293)
Synapse organization
(GO:0050808)
Zinc ion transmembrane transport
(GO:0071577)

Other Information

Proteins

Excitatory amino acid transporter 3

Genular Protein ID: 880852209

Symbol: EAA3_MOUSE

Name: Excitatory amino acid transporter 3

UniProtKB Accession Codes:

P51906 O35869 O35875 Q6P1F7

Database IDs:

Citations:

PubMed ID: 7766664

Title: Molecular cloning of two glutamate transporter subtypes from mouse brain.

PubMed ID: 7766664

DOI: 10.1016/0304-4165(95)00062-g

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9233792

Title: Glutamate transporter EAAC-1-deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration.

PubMed ID: 9233792

DOI: 10.1093/emboj/16.13.3822

PubMed ID: 12119102

Title: Molecular cloning, gene structure, expression profile and functional characterization of the mouse glutamate transporter (EAAT3) interacting protein GTRAP3-18.

PubMed ID: 12119102

DOI: 10.1016/s0378-1119(02)00669-8

PubMed ID: 18684713

Title: Modulation of the neural glutamate transporter EAAC1 by the addicsin-interacting protein ARL6IP1.

PubMed ID: 18684713

DOI: 10.1074/jbc.m801570200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 26739563

Title: Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1.

PubMed ID: 26739563

DOI: 10.1073/pnas.1519959113

PubMed ID: 30840898

Title: SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology.

PubMed ID: 30840898

DOI: 10.1016/j.celrep.2019.02.027

Sequence Information:

Length: 523
Mass: 56694
Checksum: 46F35480465E5A82
Sequence:

MGKPTSSGCD WRRFLRNHWL LLSTVAAVVL GIVLGVVVRG HSELSNLDKF YFAFPGEILM 
RMLKLVILPL IVSSMITGVA ALDSNVSGKI GLRAVVYYFS TTVIAVILGI VLVVSIKPGV 
TQKVNDINRT GKTPEVSTMD AMLDLIRNMF PENLVQACFQ QYKTKREEVK PVGDPGGNAT 
EVSVTTAMTT MSENKTKEYK IVGLYSDGIN VLGLIIFCLV FGLVIGKMGE KGQILVDFFN 
ALSDATMKIV QIIMCYMPIG ILFLIAGKII EVEDWEIFRK LGLYMATVLS GLAIHSLIVL 
PLLYFIVVRK NPFRFALGMA QALLTALMIS SSSATLPVTF RCAEEKNQVD KRITRFVLPV 
GATINMDGTA LYEAVAAVFI AQLNGLDLSI GQIVTISITA TAASIGAAGV PQAGLVTMVI 
VLSAVGLPAE DVTLIIAVDW LLDRFRTMVN VLGDAFGTGI VEKLSKKELE QMDVSSEVNI 
VNPFALEPTT LDNEDSDTKK SYVNGGFAVD KSDTISFTQT SQF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Slc1a1

Associated with

Other Information

Molecular cloning of two glutamate transporter subtypes from mouse brain. PubMed ID: 7766664

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Glutamate transporter EAAC-1-deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration. PubMed ID: 9233792

Molecular cloning, gene structure, expression profile and functional characterization of the mouse glutamate transporter (EAAT3) interacting protein GTRAP3-18. PubMed ID: 12119102

Modulation of the neural glutamate transporter EAAC1 by the addicsin-interacting protein ARL6IP1. PubMed ID: 18684713

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1. PubMed ID: 26739563

SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology. PubMed ID: 30840898