Genular: Defining Cellular Identity and Function

Details for: Slc1a3

Gene ID: 20512

Symbol: Slc1a3

Ensembl ID: ENSMUSG00000005360

Description: solute carrier family 1 (glial high affinity glutamate transporter), member 3

Associated with

Astrocytic glutamate-glutamine uptake and metabolism
(R-MMU-210455)
Glutamate neurotransmitter release cycle
(R-MMU-210500)
Neuronal system
(R-MMU-112316)
Neurotransmitter release cycle
(R-MMU-112310)
Neurotransmitter uptake and metabolism in glial cells
(R-MMU-112313)
Slc-mediated transmembrane transport
(R-MMU-425407)
Transmission across chemical synapses
(R-MMU-112315)
Transport of inorganic cations/anions and amino acids/oligopeptides
(R-MMU-425393)
Transport of small molecules
(R-MMU-382551)
Acidic amino acid transmembrane transporter activity
(GO:0015172)
Amino acid binding
(GO:0016597)
Amino acid transport
(GO:0006865)
Auditory behavior
(GO:0031223)
Basal plasma membrane
(GO:0009925)
Basolateral plasma membrane
(GO:0016323)
Cell morphogenesis involved in neuron differentiation
(GO:0048667)
Cell periphery
(GO:0071944)
Cell projection
(GO:0042995)
Cell surface
(GO:0009986)
Cellular response to cocaine
(GO:0071314)
Chloride transmembrane transport
(GO:1902476)
Cranial nerve development
(GO:0021545)
D-aspartate import across plasma membrane
(GO:0070779)
Dendritic spine
(GO:0043197)
Gamma-aminobutyric acid biosynthetic process
(GO:0009449)
Glutamate:sodium symporter activity
(GO:0015501)
Glutamate binding
(GO:0016595)
High-affinity l-glutamate transmembrane transporter activity
(GO:0005314)
Intracellular sodium ion homeostasis
(GO:0006883)
L-aspartate import across plasma membrane
(GO:0140009)
L-glutamate import
(GO:0051938)
L-glutamate import across plasma membrane
(GO:0098712)
L-glutamate transmembrane transport
(GO:0015813)
L-glutamate transmembrane transporter activity
(GO:0005313)
Malate-aspartate shuttle
(GO:0043490)
Membrane
(GO:0016020)
Membrane protein complex
(GO:0098796)
Metal ion binding
(GO:0046872)
Mitochondrial inner membrane
(GO:0005743)
Neuromuscular process controlling balance
(GO:0050885)
Neuronal cell body
(GO:0043025)
Neuron projection
(GO:0043005)
Neutral l-amino acid transmembrane transporter activity
(GO:0015175)
Plasma membrane
(GO:0005886)
Positive regulation of synaptic transmission
(GO:0050806)
Potassium ion transmembrane transport
(GO:0071805)
Protein binding
(GO:0005515)
Response to amino acid
(GO:0043200)
Response to antibiotic
(GO:0046677)
Response to inorganic substance
(GO:0010035)
Response to light stimulus
(GO:0009416)
Response to wounding
(GO:0009611)
Response to xenobiotic stimulus
(GO:0009410)
Sensory perception of sound
(GO:0007605)
Symporter activity
(GO:0015293)
Synapse
(GO:0045202)

Other Information

Proteins

Excitatory amino acid transporter 1

Genular Protein ID: 2278458188

Symbol: EAA1_MOUSE

Name: Excitatory amino acid transporter 1

UniProtKB Accession Codes:

P56564 Q99P53

Database IDs:

Citations:

PubMed ID: 7903437

Title: Cloning and expression of a glutamate transporter from mouse brain.

PubMed ID: 7903437

DOI: 10.1016/0304-3940(93)90829-a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15363892

Title: Functional analysis of glutamate transporters in excitatory synaptic transmission of GLAST1 and GLAST1/EAAC1 deficient mice.

PubMed ID: 15363892

DOI: 10.1016/j.molbrainres.2004.06.026

PubMed ID: 15390100

Title: Glutamate transport by retinal Muller cells in glutamate/aspartate transporter-knockout mice.

PubMed ID: 15390100

DOI: 10.1002/glia.20097

PubMed ID: 16880397

Title: Indispensability of the glutamate transporters GLAST and GLT1 to brain development.

PubMed ID: 16880397

DOI: 10.1073/pnas.0509144103

PubMed ID: 17114649

Title: Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

PubMed ID: 17114649

DOI: 10.1074/mcp.m600046-mcp200

PubMed ID: 19656770

Title: The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation.

PubMed ID: 19656770

DOI: 10.1074/mcp.m900195-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 28032905

Title: The amino acid transporter, SLC1A3, is plasma membrane-localised in adipocytes and its activity is insensitive to insulin.

PubMed ID: 28032905

DOI: 10.1002/1873-3468.12549

Sequence Information:

Length: 543
Mass: 59622
Checksum: E0B24CBA1D5B086D
Sequence:

MTKSNGEEPR MGGRMERLQQ GVRKRTLLAK KKVQSLTKED VKSYLFRNAF VLLTVTAVIV 
GTILGFALRP YKMSYREVKY FSFPGELLMR MLQMLVLPLI ISSLVTGMAA LDSKASGKMG 
MRAVVYYMTT TIIAVVIGII IVIIIHPGKG TKENMYREGK IVQVTAADAF LDLIRNMFPP 
NLVEACFKQF KTSYEKRSFK VPIQSNETLL GAVINNVSEA METLTRIREE MVPVPGSVNG 
VNALGLVVFS MCFGFVIGNM KEQGQALREF FDSLNEAIMR LVAVIMWYAP LGILFLIAGK 
IVEMEDMGVI GGQLAMYTVT VIVGLLIHAV IVLPLLYFLV TRKNPWVFIG GLLQALITAL 
GTSSSSATLP ITFKCLEENN GVDKRITRFV LPVGATINMD GTALYEALAA IFIAQVNNFD 
LNFGQIITIS ITATAASIGA AGIPQAGLVT MVIVLTSVGL PTDDITLIIA VDWFLDRLRT 
TTNVLGDSLG AGIVEHLSRH ELKNRDVEMG NSVIEENEMK KPYQLIAQDN EPEKPVADSE 
TKM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Slc1a3

Associated with

Other Information

Cloning and expression of a glutamate transporter from mouse brain. PubMed ID: 7903437

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Functional analysis of glutamate transporters in excitatory synaptic transmission of GLAST1 and GLAST1/EAAC1 deficient mice. PubMed ID: 15363892

Glutamate transport by retinal Muller cells in glutamate/aspartate transporter-knockout mice. PubMed ID: 15390100

Indispensability of the glutamate transporters GLAST and GLT1 to brain development. PubMed ID: 16880397

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. PubMed ID: 17114649

The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation. PubMed ID: 19656770

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The amino acid transporter, SLC1A3, is plasma membrane-localised in adipocytes and its activity is insensitive to insulin. PubMed ID: 28032905