Details for: Slc22a1

Gene ID: 20517

Symbol: Slc22a1

Ensembl ID: ENSMUSG00000023829

Description: solute carrier family 22 (organic cation transporter), member 1

Associated with

Other Information

Genular Protein ID: 3839799900

Symbol: S22A1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8854860

Title: The Lx1 gene maps to mouse chromosome 17 and codes for a protein that is homologous to glucose and polyspecific transmembrane transporters.

PubMed ID: 8854860

DOI: 10.1007/s003359900223

PubMed ID: 10216142

Title: Cloning and functional expression of a mouse liver organic cation transporter.

PubMed ID: 10216142

DOI: 10.1002/hep.510290530

PubMed ID: 12176030

Title: Functional characterization of mouse cation transporter mOCT2 compared with mOCT1.

PubMed ID: 12176030

DOI: 10.1016/s0006-291x(02)00926-9

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11463829

Title: Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene.

PubMed ID: 11463829

DOI: 10.1128/mcb.21.16.5471-5477.2001

PubMed ID: 15458920

Title: Transcriptional regulation of murine Slc22a1 (Oct1) by peroxisome proliferator agonist receptor-alpha and -gamma.

PubMed ID: 15458920

DOI: 10.1152/ajpgi.00057.2004

PubMed ID: 16381671

Title: Tissue distribution and ontogeny of organic cation transporters in mice.

PubMed ID: 16381671

DOI: 10.1124/dmd.105.006932

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23458604

Title: Polyamine transport by the polyspecific organic cation transporters OCT1, OCT2, and OCT3.

PubMed ID: 23458604

DOI: 10.1021/mp400024d

PubMed ID: 23680637

Title: Organic cation transporter 1 (OCT1/mOct1) is localized in the apical membrane of Caco-2 cell monolayers and enterocytes.

PubMed ID: 23680637

DOI: 10.1124/mol.112.084517

PubMed ID: 24961373

Title: OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.

PubMed ID: 24961373

DOI: 10.1073/pnas.1314939111

PubMed ID: 28942964

Title: Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport.

PubMed ID: 28942964

DOI: 10.1016/j.ajhg.2017.08.008

PubMed ID: 34040533

Title: Isobutyrylcarnitine as a Biomarker of OCT1 Activity and Interspecies Differences in its Membrane Transport.

PubMed ID: 34040533

DOI: 10.3389/fphar.2021.674559

PubMed ID: 35469921

Title: Amino acids in transmembrane helix 1 confer major functional differences between human and mouse orthologs of the polyspecific membrane transporter OCT1.

PubMed ID: 35469921

DOI: 10.1016/j.jbc.2022.101974

Sequence Information:

  • Length: 556
  • Mass: 61521
  • Checksum: 0230EF5A2B1E2723
  • Sequence:
  • MPTVDDVLEH VGEFGWFQKQ AFLLLCLISA SLAPIYVGIV FLGFTPDHHC RSPGVAELSQ 
    RCGWSPAEEL NYTVPGLGSA GEASFLSQCM KYEVDWNQST LDCVDPLSSL AANRSHLPLS 
    PCEHGWVYDT PGSSIVTEFN LVCGDAWKVD LFQSCVNLGF FLGSLVVGYI ADRFGRKLCL 
    LVTTLVTSLS GVLTAVAPDY TSMLLFRLLQ GMVSKGSWVS GYTLITEFVG SGYRRTTAIL 
    YQVAFTVGLV GLAGVAYAIP DWRWLQLAVS LPTFLFLLYY WFVPESPRWL LSQKRTTQAV 
    RIMEQIAQKN RKVPPADLKM MCLEEDASER RSPSFADLFR TPSLRKHTLI LMYLWFSCAV 
    LYQGLIMHVG ATGANLYLDF FYSSLVEFPA AFIILVTIDR IGRIYPIAAS NLVAGAACLL 
    MIFIPHELHW LNVTLACLGR MGATIVLQMV CLVNAELYPT FIRNLGMMVC SALCDLGGIF 
    TPFMVFRLME VWQALPLILF GVLGLSAGAV TLLLPETKGV ALPETIEEAE NLGRRKSKAK 
    ENTIYLQVQT GKSPHT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.