Genular: Defining Cellular Identity and Function

Details for: Slc22a3

Gene ID: 20519

Symbol: Slc22a3

Ensembl ID: ENSMUSG00000023828

Description: solute carrier family 22 (organic cation transporter), member 3

Associated with

Abacavir adme
(R-MMU-2161522)
Abacavir transmembrane transport
(R-MMU-2161517)
Drug adme
(R-MMU-9748784)
Organic cation/anion/zwitterion transport
(R-MMU-549132)
Slc-mediated transmembrane transport
(R-MMU-425407)
Transport of bile salts and organic acids, metal ions and amine compounds
(R-MMU-425366)
Transport of small molecules
(R-MMU-382551)
Apical plasma membrane
(GO:0016324)
Basolateral plasma membrane
(GO:0016323)
Dopamine:sodium symporter activity
(GO:0005330)
Dopamine transport
(GO:0015872)
Dopamine uptake
(GO:0090494)
Endomembrane system
(GO:0012505)
Epinephrine transport
(GO:0048241)
Epinephrine uptake
(GO:0051625)
Establishment of localization in cell
(GO:0051649)
Histamine transport
(GO:0051608)
Histamine uptake
(GO:0051615)
Membrane
(GO:0016020)
Mitochondrial membrane
(GO:0031966)
Mitochondrion
(GO:0005739)
Monoamine transmembrane transporter activity
(GO:0008504)
Monoamine transport
(GO:0015844)
Monoatomic ion transport
(GO:0006811)
Monocarboxylic acid transport
(GO:0015718)
Neuronal cell body
(GO:0043025)
Neurotransmitter transmembrane transporter activity
(GO:0005326)
Neurotransmitter transport
(GO:0006836)
Norepinephrine transport
(GO:0015874)
Norepinephrine uptake
(GO:0051620)
Nucleus
(GO:0005634)
Organic anion transmembrane transporter activity
(GO:0008514)
Organic anion transport
(GO:0015711)
Organic cation transmembrane transporter activity
(GO:0015101)
Organic cation transport
(GO:0015695)
Organic hydroxy compound transport
(GO:0015850)
Plasma membrane
(GO:0005886)
Quaternary ammonium group transmembrane transporter activity
(GO:0015651)
Quaternary ammonium group transport
(GO:0015697)
Regulation of appetite
(GO:0032098)
Serotonin transport
(GO:0006837)
Serotonin uptake
(GO:0051610)
Spermidine transmembrane transporter activity
(GO:0015606)
Spermidine transport
(GO:0015848)
Toxin transmembrane transporter activity
(GO:0019534)
Toxin transport
(GO:1901998)
Transmembrane transport
(GO:0055085)
Transmembrane transporter activity
(GO:0022857)
Xenobiotic transport
(GO:0042908)

Other Information

Proteins

S22A3_MOUSE

Genular Protein ID: 522854920

Symbol: S22A3_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9WTW5 Q9R209

Database IDs:

Citations:

PubMed ID: 9933568

Title: Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27.

PubMed ID: 9933568

DOI: 10.1006/geno.1998.5639

PubMed ID: 10966924

Title: Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney.

PubMed ID: 10966924

DOI: 10.1152/ajprenal.2000.279.3.f449

PubMed ID: 18513366

Title: Altered aminergic neurotransmission in the brain of organic cation transporter 3-deficient mice.

PubMed ID: 18513366

DOI: 10.1111/j.1471-4159.2008.05506.x

PubMed ID: 19416912

Title: The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway.

PubMed ID: 19416912

DOI: 10.1073/pnas.0900358106

PubMed ID: 27659446

Title: Organic cation transporter 3 (OCT3) is localized to intracellular and surface membranes in select glial and neuronal cells within the basolateral amygdaloid complex of both rats and mice.

PubMed ID: 27659446

DOI: 10.1007/s00429-016-1315-9

Sequence Information:

Length: 551
Mass: 61053
Checksum: C4D66AAC2EFCFBDB
Sequence:

MPTFDQALRK AGEFGRFQRR VFLLLCLTGV TFAFLFVGVV FLGSQPDYYW CRGPRATALA 
ERCAWSPEEE WNLTTPELHV PAERRGQGHC HRYLLEATNT SSELSCDPLT AFPNRSAPLV 
SCSGDWRYVE THSTIVSQFD LVCSNAWMLD LTQAILNLGF LAGAFTLGYA ADRYGRLIIY 
LISCFGVGIT GVVVAFAPNF SVFVIFRFLQ GVFGKGAWMT CFVIVTEIVG SKQRRIVGIV 
IQMFFTLGII ILPGIAYFTP SWQGIQLAIS LPSFLFLLYY WVVPESPRWL ITRKQGEKAL 
QILRRVAKCN GKHLSSNYSE ITVTDEEVSN PSCLDLVRTP QMRKCTLILM FAWFTSAVVY 
QGLVMRLGLI GGNLYIDFFI SGLVELPGAL LILLTIERLG RRLPFAASNI VAGVSCLVTA 
FLPEGIPWLR TTVATLGRLG ITMAFEIVYL VNSELYPTTL RNFGVSLCSG LCDFGGIIAP 
FLLFRLAAIW LELPLIIFGI LASVCGGLVM LLPETKGIAL PETVEDVEKL GSSQLHQCGR 
KKKTQVSTSD V

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Slc22a3

Associated with

Other Information

Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27. PubMed ID: 9933568

Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. PubMed ID: 10966924

Altered aminergic neurotransmission in the brain of organic cation transporter 3-deficient mice. PubMed ID: 18513366