Genular: Defining Cellular Identity and Function

Details for: Slc2a4

Gene ID: 20528

Symbol: Slc2a4

Ensembl ID: ENSMUSG00000018566

Description: solute carrier family 2 (facilitated glucose transporter), member 4

Associated with

Cellular hexose transport
(R-MMU-189200)
Slc-mediated transmembrane transport
(R-MMU-425407)
Transport of small molecules
(R-MMU-382551)
Amylopectin biosynthetic process
(GO:0010021)
Brown fat cell differentiation
(GO:0050873)
Carbohydrate transport
(GO:0008643)
Cell surface
(GO:0009986)
Cellular response to hypoxia
(GO:0071456)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to osmotic stress
(GO:0071470)
Cellular response to tumor necrosis factor
(GO:0071356)
Clathrin-coated pit
(GO:0005905)
Clathrin-coated vesicle
(GO:0030136)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle membrane
(GO:0030659)
Cytosol
(GO:0005829)
D-glucose transmembrane transporter activity
(GO:0055056)
Dehydroascorbic acid transport
(GO:0070837)
Endomembrane system
(GO:0012505)
Endosome
(GO:0005768)
External side of plasma membrane
(GO:0009897)
Extracellular exosome
(GO:0070062)
Glucose homeostasis
(GO:0042593)
Glucose import
(GO:0046323)
Glucose import in response to insulin stimulus
(GO:0044381)
Glucose transmembrane transport
(GO:1904659)
Glucose transmembrane transporter activity
(GO:0005355)
Glucose uniporter activity
(GO:0015304)
Insulin-responsive compartment
(GO:0032593)
Insulin-responsive glucose:proton symporter activity
(GO:0005360)
Learning or memory
(GO:0007611)
Long-term memory
(GO:0007616)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Multivesicular body
(GO:0005771)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of brain-derived neurotrophic factor receptor signaling pathway
(GO:0031550)
Presynapse
(GO:0098793)
Protein binding
(GO:0005515)
Regulation of synaptic vesicle budding from presynaptic endocytic zone membrane
(GO:0098694)
Sarcolemma
(GO:0042383)
Sarcoplasmic reticulum
(GO:0016529)
Short-term memory
(GO:0007614)
T-tubule
(GO:0030315)
Trans-golgi network
(GO:0005802)
Trans-golgi network transport vesicle
(GO:0030140)
Transmembrane transport
(GO:0055085)
Transmembrane transporter activity
(GO:0022857)
Vesicle
(GO:0031982)
Vesicle membrane
(GO:0012506)

Other Information

Proteins

GLUT4_MOUSE

Genular Protein ID: 721126897

Symbol: GLUT4_MOUSE

Name: N/A

UniProtKB Accession Codes:

P14142 Q3TPK6 Q9JJN9

Database IDs:

Citations:

PubMed ID: 2654938

Title: Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes.

PubMed ID: 2654938

DOI: 10.1073/pnas.86.9.3150

PubMed ID: 10952468

Title: Age-dependent changes in phenotypes and candidate gene analysis in a polygenic animal model of type II diabetes; NSY mouse.

PubMed ID: 10952468

DOI: 10.1007/s001250051472

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12637568

Title: Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation.

PubMed ID: 12637568

DOI: 10.1074/jbc.c300063200

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21907143

Title: C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane.

PubMed ID: 21907143

DOI: 10.1016/j.cmet.2011.06.015

PubMed ID: 25586176

Title: Tumor necrosis factor (TNF)-alpha-induced repression of GKAP42 protein levels through cGMP-dependent kinase (cGK)-Ialpha causes insulin resistance in 3T3-L1 adipocytes.

PubMed ID: 25586176

DOI: 10.1074/jbc.m114.624759

PubMed ID: 26240143

Title: Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumor Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in Adipocytes.

PubMed ID: 26240143

DOI: 10.1074/jbc.m115.657361

PubMed ID: 26629404

Title: TUSC5 regulates insulin-mediated adipose tissue glucose uptake by modulation of GLUT4 recycling.

PubMed ID: 26629404

DOI: 10.1016/j.molmet.2015.08.003

PubMed ID: 27354378

Title: SEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes.

PubMed ID: 27354378

DOI: 10.1083/jcb.201509052

PubMed ID: 27739494

Title: A novel IRS-1-associated protein, DGKzeta regulates GLUT4 translocation in 3T3-L1 adipocytes.

PubMed ID: 27739494

DOI: 10.1038/srep35438

Sequence Information:

Length: 509
Mass: 54755
Checksum: A174212455EE0390
Sequence:

MPSGFQQIGS DDGEPPRQRV TGTLVLAVFS AVLGSLQFGY NIGVINAPQK VIEQSYNATW 
LGRQGPGGPD SIPQGTLTTL WALSVAIFSV GGMISSFLIG IISQWLGRKR AMLANNVLAV 
LGGALMGLAN AAASYEILIL GRFLIGAYSG LTSGLVPMYV GEIAPTHLRG ALGTLNQLAI 
VIGILVAQVL GLESMLGTAT LWPLLLALTV LPALLQLILL PFCPESPRYL YIIRNLEGPA 
RKSLKRLTGW ADVSDALAEL KDEKRKLERE RPMSLLQLLG SRTHRQPLII AVVLQLSQQL 
SGINAVFYYS TSIFESAGVG QPAYATIGAG VVNTVFTLVS VLLVERAGRR TLHLLGLAGM 
CGCAILMTVA LLLLERVPAM SYVSIVAIFG FVAFFEIGPG PIPWFIVAEL FSQGPRPAAM 
AVAGFSNWTC NFIVGMGFQY VADAMGPYVF LLFAVLLLGF FIFTFLKVPE TRGRTFDQIS 
AAFRRTPSLL EQEVKPSTEL EYLGPDEND

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Slc2a4

Associated with

Other Information

Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes. PubMed ID: 2654938

Age-dependent changes in phenotypes and candidate gene analysis in a polygenic animal model of type II diabetes; NSY mouse. PubMed ID: 10952468

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation. PubMed ID: 12637568

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. PubMed ID: 19349973

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane. PubMed ID: 21907143

Tumor necrosis factor (TNF)-alpha-induced repression of GKAP42 protein levels through cGMP-dependent kinase (cGK)-Ialpha causes insulin resistance in 3T3-L1 adipocytes. PubMed ID: 25586176

Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumor Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in Adipocytes. PubMed ID: 26240143

TUSC5 regulates insulin-mediated adipose tissue glucose uptake by modulation of GLUT4 recycling. PubMed ID: 26629404

SEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes. PubMed ID: 27354378

A novel IRS-1-associated protein, DGKzeta regulates GLUT4 translocation in 3T3-L1 adipocytes. PubMed ID: 27739494