Genular: Defining Cellular Identity and Function

Details for: Slc31a1

Gene ID: 20529

Symbol: Slc31a1

Ensembl ID: ENSMUSG00000066150

Description: solute carrier family 31, member 1

Associated with

Metal ion slc transporters
(R-MMU-425410)
Slc-mediated transmembrane transport
(R-MMU-425407)
Transport of bile salts and organic acids, metal ions and amine compounds
(R-MMU-425366)
Transport of small molecules
(R-MMU-382551)
Angiogenesis
(GO:0001525)
Apical plasma membrane
(GO:0016324)
Basolateral plasma membrane
(GO:0016323)
Cellular response to cisplatin
(GO:0072719)
Copper ion binding
(GO:0005507)
Copper ion import
(GO:0015677)
Copper ion import across plasma membrane
(GO:0098705)
Copper ion transmembrane transport
(GO:0035434)
Copper ion transmembrane transporter activity
(GO:0005375)
Copper ion transport
(GO:0006825)
Early endosome membrane
(GO:0031901)
Endosome
(GO:0005768)
Establishment of localization in cell
(GO:0051649)
Identical protein binding
(GO:0042802)
Intercalated disc
(GO:0014704)
Intracellular copper ion homeostasis
(GO:0006878)
Late endosome
(GO:0005770)
Membrane
(GO:0016020)
Monoatomic ion transport
(GO:0006811)
Neuronal cell body
(GO:0043025)
Plasma membrane
(GO:0005886)
Plasma membrane copper ion transport
(GO:0015679)
Protein binding
(GO:0005515)
Protein complex oligomerization
(GO:0051259)
Recycling endosome
(GO:0055037)
Recycling endosome membrane
(GO:0055038)
Silver ion transmembrane transport
(GO:1902601)
Silver ion transmembrane transporter activity
(GO:0015080)
Transmembrane transport
(GO:0055085)
Vascular endothelial growth factor receptor-2 signaling pathway
(GO:0036324)
Xenobiotic transmembrane transporter activity
(GO:0042910)
Xenobiotic transport
(GO:0042908)

Other Information

Proteins

Solute carrier family 31 member 1

Genular Protein ID: 195708263

Symbol: COPT1_MOUSE

Name: Solute carrier family 31 member 1

UniProtKB Accession Codes:

Q8K211 Q3UAJ9 Q8BXJ1

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11391004

Title: The copper transporter CTR1 provides an essential function in mammalian embryonic development.

PubMed ID: 11391004

DOI: 10.1073/pnas.111057298

PubMed ID: 11391005

Title: Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development.

PubMed ID: 11391005

DOI: 10.1073/pnas.111058698

PubMed ID: 12177073

Title: Characterization of mouse embryonic cells deficient in the ctr1 high affinity copper transporter. Identification of a Ctr1-independent copper transport system.

PubMed ID: 12177073

DOI: 10.1074/jbc.m208002200

PubMed ID: 12370430

Title: Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals.

PubMed ID: 12370430

DOI: 10.1073/pnas.162491399

PubMed ID: 16950140

Title: Ctr1 drives intestinal copper absorption and is essential for growth, iron metabolism, and neonatal cardiac function.

PubMed ID: 16950140

DOI: 10.1016/j.cmet.2006.08.009

PubMed ID: 16847145

Title: Contribution of the major copper influx transporter CTR1 to the cellular accumulation of cisplatin, carboplatin, and oxaliplatin.

PubMed ID: 16847145

DOI: 10.1124/mol.106.022624

PubMed ID: 19144690

Title: The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity.

PubMed ID: 19144690

DOI: 10.1152/ajprenal.90545.2008

PubMed ID: 20699218

Title: Ctr1 is an apical copper transporter in mammalian intestinal epithelial cells in vivo that is controlled at the level of protein stability.

PubMed ID: 20699218

DOI: 10.1074/jbc.m110.143826

PubMed ID: 20569931

Title: Ctr1 transports silver into mammalian cells.

PubMed ID: 20569931

DOI: 10.1016/j.jtemb.2010.01.009

PubMed ID: 24167251

Title: Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain.

PubMed ID: 24167251

DOI: 10.1073/pnas.1311749110

PubMed ID: 27143361

Title: Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain.

PubMed ID: 27143361

DOI: 10.1074/jbc.m116.731281

PubMed ID: 35027734

Title: Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis.

PubMed ID: 35027734

DOI: 10.1038/s41556-021-00822-7

PubMed ID: 31002737

Title: Copper transporter 1 (CTR1) expression by mouse testicular germ cells, but not Sertoli cells, is essential for functional spermatogenesis.

PubMed ID: 31002737

DOI: 10.1371/journal.pone.0215522

Sequence Information:

Length: 196
Mass: 21961
Checksum: A4EDDD2A9E51AF10
Sequence:

MNHMGMNHME MHHHMGMNHT DDNITMPPHH HPTTSASHSH GGGDSMMMMP MTFYFDFKNV 
NLLFSGLVIN TPGEMAGAFV AVFLLAMFYE GLKIAREGLL RKSQVSIRYN SMPVPGPNGT 
ILMETHKTVG QQMLSFPHLL QTVLHIIQVV ISYFLMLIFM TYNGYLCIAV AAGAGTGYFL 
FSWKKAVVVD ITEHCH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Slc31a1

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The copper transporter CTR1 provides an essential function in mammalian embryonic development. PubMed ID: 11391004

Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development. PubMed ID: 11391005

Characterization of mouse embryonic cells deficient in the ctr1 high affinity copper transporter. Identification of a Ctr1-independent copper transport system. PubMed ID: 12177073

Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals. PubMed ID: 12370430

Ctr1 drives intestinal copper absorption and is essential for growth, iron metabolism, and neonatal cardiac function. PubMed ID: 16950140

Contribution of the major copper influx transporter CTR1 to the cellular accumulation of cisplatin, carboplatin, and oxaliplatin. PubMed ID: 16847145

The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity. PubMed ID: 19144690

Ctr1 is an apical copper transporter in mammalian intestinal epithelial cells in vivo that is controlled at the level of protein stability. PubMed ID: 20699218

Ctr1 transports silver into mammalian cells. PubMed ID: 20569931

Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain. PubMed ID: 24167251

Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain. PubMed ID: 27143361

Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis. PubMed ID: 35027734

Copper transporter 1 (CTR1) expression by mouse testicular germ cells, but not Sertoli cells, is essential for functional spermatogenesis. PubMed ID: 31002737