Genular: Defining Cellular Identity and Function

Details for: Slc7a5

Gene ID: 20539

Symbol: Slc7a5

Ensembl ID: ENSMUSG00000040010

Description: solute carrier family 7 (cationic amino acid transporter, y+ system), member 5

Associated with

Amino acid transport across the plasma membrane
(R-MMU-352230)
Basigin interactions
(R-MMU-210991)
Cell surface interactions at the vascular wall
(R-MMU-202733)
Hemostasis
(R-MMU-109582)
Metabolism
(R-MMU-1430728)
Metabolism of amino acids and derivatives
(R-MMU-71291)
Slc-mediated transmembrane transport
(R-MMU-425407)
Transport of inorganic cations/anions and amino acids/oligopeptides
(R-MMU-425393)
Transport of small molecules
(R-MMU-382551)
Tryptophan catabolism
(R-MMU-71240)
Alanine transport
(GO:0032328)
Amino acid import across plasma membrane
(GO:0089718)
Amino acid transmembrane transport
(GO:0003333)
Amino acid transmembrane transporter activity
(GO:0015171)
Amino acid transport
(GO:0006865)
Amino acid transport complex
(GO:1990184)
Antiporter activity
(GO:0015297)
Apical plasma membrane
(GO:0016324)
Aromatic amino acid transmembrane transporter activity
(GO:0015173)
Basal plasma membrane
(GO:0009925)
Basolateral plasma membrane
(GO:0016323)
Cytosol
(GO:0005829)
External side of apical plasma membrane
(GO:0098591)
Intracellular membrane-bounded organelle
(GO:0043231)
Isoleucine transport
(GO:0015818)
L-alpha-amino acid transmembrane transport
(GO:1902475)
L-amino acid transmembrane transporter activity
(GO:0015179)
L-amino acid transport
(GO:0015807)
L-histidine transport
(GO:1902024)
L-leucine import across plasma membrane
(GO:1903801)
L-leucine transmembrane transporter activity
(GO:0015190)
L-tryptophan transmembrane transport
(GO:1904556)
L-tryptophan transmembrane transporter activity
(GO:0015196)
Leucine import across plasma membrane
(GO:0098713)
Leucine transport
(GO:0015820)
Lysosome
(GO:0005764)
Membrane
(GO:0016020)
Methionine transport
(GO:0015821)
Microvillus membrane
(GO:0031528)
Negative regulation of autophagy
(GO:0010507)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of vascular associated smooth muscle cell apoptotic process
(GO:1905460)
Neutral amino acid transport
(GO:0015804)
Neutral l-amino acid transmembrane transporter activity
(GO:0015175)
Phenylalanine transport
(GO:0015823)
Plasma membrane
(GO:0005886)
Positive regulation of glial cell proliferation
(GO:0060252)
Positive regulation of interleukin-4 production
(GO:0032753)
Positive regulation of interleukin-17 production
(GO:0032740)
Positive regulation of leucine import across plasma membrane
(GO:1905534)
Positive regulation of type ii interferon production
(GO:0032729)
Proline transport
(GO:0015824)
Protein binding
(GO:0005515)
Thyroid hormone transmembrane transporter activity
(GO:0015349)
Thyroid hormone transport
(GO:0070327)
Transmembrane transport
(GO:0055085)
Transmembrane transporter activity
(GO:0022857)
Tryptophan transport
(GO:0015827)
Tyrosine transport
(GO:0015828)
Valine transport
(GO:0015829)
Xenobiotic transport
(GO:0042908)

Other Information

Proteins

Large neutral amino acids transporter small subunit 1

Genular Protein ID: 3339275489

Symbol: LAT1_MOUSE

Name: Large neutral amino acids transporter small subunit 1

UniProtKB Accession Codes:

Q9Z127 Q8R0X8 Q9JMI4

Database IDs:

Citations:

PubMed ID: 9915839

Title: 4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer.

PubMed ID: 9915839

DOI: 10.1074/jbc.274.5.3009

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10574970

Title: LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine.

PubMed ID: 10574970

DOI: 10.1074/jbc.274.49.34948

PubMed ID: 11011012

Title: The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier.

PubMed ID: 11011012

DOI: 10.1016/s0006-8993(00)02758-x

PubMed ID: 11117468

Title: Distribution of the 4F2 light chain, LAT1, in the mouse brain.

PubMed ID: 11117468

DOI: 10.1097/00001756-200011270-00015

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 512
Mass: 55872
Checksum: 57045EC4DD9DE1A1
Sequence:

MAVAGAKRRA VATPAAAAAE EERQAREKML EARRGDGADP EGEGVTLQRN ITLLNGVAII 
VGTIIGSGIF VTPTGVLKEA GSPGLSLVVW AVCGVFSIVG ALCYAELGTT ISKSGGDYAY 
MLEVYGSLPA FLKLWIELLI IRPSSQYIVA LVFATYLLKP VFPTCPVPEE AAKLVACLCV 
LLLTAVNCYS VKAATRVQDA FAAAKLLALA LIILLGFIQM GKDMGQGDAS NLQQKLSFEG 
TNLDVGNIVL ALYSGLFAYG GWNYLNFVTE EMINPYRNLP LAIIISLPIV TLVYVLTNLA 
YFTTLSTNQM LTSEAVAVDF GNYHLGVMSW IIPVFVGLSC FGSVNGSLFT SSRLFFVGSR 
EGHLPSVLSM IHPQLLTPVP SLVFTCIMTL MYAFSRDIFS IINFFSFFNW LCVALAIIGM 
MWLRFKKPEL ERPIKVNLAL PVFFILACLF LIAVSFWKTP MECGIGFAII LSGLPVYFFG 
VWWKNKPKWI LQAIFSVTVL CQKLMQVVPQ ET

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Slc7a5

Associated with

Other Information

4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer. PubMed ID: 9915839

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine. PubMed ID: 10574970

The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier. PubMed ID: 11011012

Distribution of the 4F2 light chain, LAT1, in the mouse brain. PubMed ID: 11117468