Genular: Defining Cellular Identity and Function

Details for: Slc9a1

Gene ID: 20544

Symbol: Slc9a1

Ensembl ID: ENSMUSG00000028854

Description: solute carrier family 9 (sodium/hydrogen exchanger), member 1

Associated with

Glycosaminoglycan metabolism
(R-MMU-1630316)
Hyaluronan metabolism
(R-MMU-2142845)
Hyaluronan uptake and degradation
(R-MMU-2160916)
Metabolism
(R-MMU-1430728)
Metabolism of carbohydrates
(R-MMU-71387)
Slc-mediated transmembrane transport
(R-MMU-425407)
Sodium/proton exchangers
(R-MMU-425986)
Transport of inorganic cations/anions and amino acids/oligopeptides
(R-MMU-425393)
Transport of small molecules
(R-MMU-382551)
Antiporter activity
(GO:0015297)
Apical plasma membrane
(GO:0016324)
Basolateral plasma membrane
(GO:0016323)
Calcium-dependent protein binding
(GO:0048306)
Calmodulin binding
(GO:0005516)
Cardiac muscle cell differentiation
(GO:0055007)
Cation-transporting atpase complex
(GO:0090533)
Cell surface
(GO:0009986)
Cellular response to acidic ph
(GO:0071468)
Cellular response to epinephrine stimulus
(GO:0071872)
Cellular response to hypoxia
(GO:0071456)
Cellular response to insulin stimulus
(GO:0032869)
Cytoplasm
(GO:0005737)
Embryo development
(GO:0009790)
Hyaluronan catabolic process
(GO:0030214)
Identical protein binding
(GO:0042802)
Intercalated disc
(GO:0014704)
Intracellular sodium ion homeostasis
(GO:0006883)
Ion binding
(GO:0043167)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Monoatomic cation transport
(GO:0006812)
Monoatomic ion transport
(GO:0006811)
Negative regulation of apoptotic process
(GO:0043066)
Nucleoplasm
(GO:0005654)
Perinuclear region of cytoplasm
(GO:0048471)
Phospholipid binding
(GO:0005543)
Plasma membrane
(GO:0005886)
Positive regulation of action potential
(GO:0045760)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of calcineurin-nfat signaling cascade
(GO:0070886)
Positive regulation of calcium:sodium antiporter activity
(GO:1903281)
Positive regulation of cardiac muscle hypertrophy
(GO:0010613)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of intracellular signal transduction
(GO:1902533)
Positive regulation of mitochondrial membrane permeability
(GO:0035794)
Positive regulation of the force of heart contraction
(GO:0098735)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Potassium:proton antiporter activity
(GO:0015386)
Potassium ion transmembrane transport
(GO:0071805)
Protein phosphatase 2b binding
(GO:0030346)
Proton transmembrane transport
(GO:1902600)
Regulation of cardiac muscle contraction by calcium ion signaling
(GO:0010882)
Regulation of intracellular ph
(GO:0051453)
Regulation of ph
(GO:0006885)
Regulation of the force of heart contraction
(GO:0002026)
Regulation of the force of heart contraction by cardiac conduction
(GO:0086092)
Response to acidic ph
(GO:0010447)
Response to muscle stretch
(GO:0035994)
Response to organic cyclic compound
(GO:0014070)
Sarcolemma
(GO:0042383)
Sodium:proton antiporter activity
(GO:0015385)
Sodium ion import across plasma membrane
(GO:0098719)
Sodium ion transport
(GO:0006814)
Stem cell differentiation
(GO:0048863)
T-tubule
(GO:0030315)
Transmembrane transport
(GO:0055085)
Transporter complex
(GO:1990351)

Other Information

Proteins

Sodium/hydrogen exchanger 1

Genular Protein ID: 885665739

Symbol: SL9A1_MOUSE

Name: Sodium/hydrogen exchanger 1

UniProtKB Accession Codes:

Q61165

Database IDs:

Citations:

PubMed ID: 11931388

Title: cDNA cloning and expression of the mouse Na/H antiporter (NHE-1) and a potential splice variant.

PubMed ID: 11931388

DOI: 10.1023/a:1017984311138

PubMed ID: 9335342

Title: Sodium/hydrogen exchanger gene defect in slow-wave epilepsy mutant mice.

PubMed ID: 9335342

DOI: 10.1016/s0092-8674(01)80016-7

PubMed ID: 10199808

Title: Targeted disruption of the murine Nhe1 locus induces ataxia, growth retardation, and seizures.

PubMed ID: 10199808

DOI: 10.1152/ajpcell.1999.276.4.c788

PubMed ID: 17114649

Title: Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

PubMed ID: 17114649

DOI: 10.1074/mcp.m600046-mcp200

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19369449

Title: Nhe1 is a luminal Na+/H+ exchanger in mouse choroid plexus and is targeted to the basolateral membrane in Ncbe/Nbcn2-null mice.

PubMed ID: 19369449

DOI: 10.1152/ajpcell.00062.2009

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 820
Mass: 91468
Checksum: 0589C4D08DD348BE
Sequence:

MMLRWSGVWG FHPPRIFPSL LVVVALVGLL PVLRSHGLQH SPTASTIRGS EPPRERSIGD 
VTTAPSEPLH RPDDHNLTNL IIEHGGKPSR KAFPVLDIDY PHVRTPFEIS LWILLACLMK 
IGFHVIPTIS SIVPESCLLI VVGLLVGGLI KGVGETPPFL QSDVFFLFLL PPIILDAGYF 
LPLRQFTENL GTILIFAVVG TLWNAFFLGG LLYAVCLVGG EQINNIGLLD TLLFGSIISA 
VDPVAVLAVF EEIHINELLH ILVFGESLLN DAVTVVLYHL FEEFASYDSV GISDIFLGFL 
SFFVVALGGV FVGVVYGVIA AFTSRFTSHI RVIEPLFVFL YSYMAYLSAE LFHLSGIMAL 
IASGVVMRPY VEANISHKSH TTIKYFLKMW SSVSETLIFI FLGVSTVAGS HQWNWTFVIS 
TLLFCLIARV LGVLVLTWFI NKFRIVKLTP KDQFIIAYGG LRGAIAFSLG YLLDKKHFPM 
CDLFLTAIIT VIFFTVFVQG MTIRPLVDLL AVKKKQETKR SINEEIHTQF LDHLLTGIED 
ICGHYGHHHW KDKLNRFNKK YVKKCLIAGE RSKEPQLIAF YHKMEMKQAI ELVESGGMGK 
IPSAVSTVSM QNIHPKAVTS DRILPALSKD KEEEIRKILR SNLQKTRQRL RSYNRHTLVA 
DPYEEAWNQM LLRRQKARQL EQKITNYLTV PAHKLDSPTL SRARIGSDPL AYEPKADLPV 
ITIDPASPQS PESVDLVNEE LKGKVLGLNR GPRVTPEEEE EDEDGIIMIR SKEPSSPGTD 
DVFTPGSSDS PSSQRIQRCL SDPGPHPEPG EGEPFIPKGQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Slc9a1

Associated with

Other Information

cDNA cloning and expression of the mouse Na/H antiporter (NHE-1) and a potential splice variant. PubMed ID: 11931388

Sodium/hydrogen exchanger gene defect in slow-wave epilepsy mutant mice. PubMed ID: 9335342

Targeted disruption of the murine Nhe1 locus induces ataxia, growth retardation, and seizures. PubMed ID: 10199808

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. PubMed ID: 17114649

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Nhe1 is a luminal Na+/H+ exchanger in mouse choroid plexus and is targeted to the basolateral membrane in Ncbe/Nbcn2-null mice. PubMed ID: 19369449

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079