Details for: Slfn2

Gene ID: 20556

Symbol: Slfn2

Ensembl ID: ENSMUSG00000072620

Description: schlafen 2

Associated with

Other Information

Genular Protein ID: 3359689383

Symbol: SLFN2_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9Z0I6

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 7 Ensembl 1 GO 13 Gene3D 1 GeneTree 1 HOGENOM 1 InParanoid 1 InterPro 4 KEGG 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 9846487

Title: Schlafen, a new family of growth regulatory genes that affect thymocyte development.

PubMed ID: 9846487

DOI: 10.1016/s1074-7613(00)80663-9

PubMed ID: 30275530

Title: Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci.

PubMed ID: 30275530

DOI: 10.1038/s41588-018-0223-8

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19592487

Title: Role of Schlafen 2 (SLFN2) in the generation of interferon alpha-induced growth inhibitory responses.

PubMed ID: 19592487

DOI: 10.1074/jbc.m109.030445

PubMed ID: 20190759

Title: An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence.

PubMed ID: 20190759

DOI: 10.1038/ni.1847

PubMed ID: 27276683

Title: Schlafen2 mutation unravels a role for chronic ER stress in the loss of T cell quiescence.

PubMed ID: 27276683

DOI: 10.18632/oncotarget.9818

PubMed ID: 28672048

Title: Slfn2 mutation-induced loss of T-cell quiescence leads to elevated de novo sterol synthesis.

PubMed ID: 28672048

DOI: 10.1111/imm.12785

PubMed ID: 33986151

Title: SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity.

PubMed ID: 33986151

DOI: 10.1126/science.aba4220

Sequence Information:

  • Length: 378
  • Mass: 42438
  • Checksum: 31864CC15A50A69E
  • Sequence:
    • MGTRLEATEQ SNHRTQRNDI QLENAKAAGK MGISVDLEAK YAKLGLNLGA ITFGEKDRKK 
MKNSHLRKQE NANISLAVCA LLNSGGGAIK VKIENENYSL TRDGLGLDLE ASLCKCLPFV 
QWHLDFTESE GYIYIYVKSW SQEIFGLPIG TLRTNLYVRS MSSSVQVSAA AALEFLQDLE 
ETGGRPCVRP ELPASIAFPE VEGEWHLEDL AAALFNRTEF QYEETFPFTR SRYVEVTLLS 
AKRLRKRIKE LLPQTVSAFA NTDGGFLFIG LDGKTQQIIG FEAEKSDLVL LESEIEKHIR 
QLPVTHFCEE KEKIKYTCKF IEVHKSGAVC AYVCALRVER FCCAVFAAEP ESWHVEGGCV 
KRFTTEEWVK LQMNAPSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.