Details for: Snai2

Gene ID: 20583

Symbol: Snai2

Ensembl ID: ENSMUSG00000022676

Description: snail family zinc finger 2

Associated with

  • Cartilage morphogenesis
    (GO:0060536)
  • Cell migration involved in endocardial cushion formation
    (GO:0003273)
  • Cellular response to epidermal growth factor stimulus
    (GO:0071364)
  • Cellular response to ionizing radiation
    (GO:0071479)
  • Cellular response to platelet-derived growth factor stimulus
    (GO:0036120)
  • Chromatin
    (GO:0000785)
  • Chromatin binding
    (GO:0003682)
  • Chromatin organization
    (GO:0006325)
  • Cytoplasm
    (GO:0005737)
  • Desmosome disassembly
    (GO:0035921)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • E-box binding
    (GO:0070888)
  • Endothelial cell migration
    (GO:0043542)
  • Epithelial cell migration
    (GO:0010631)
  • Epithelial to mesenchymal transition
    (GO:0001837)
  • Epithelial to mesenchymal transition involved in endocardial cushion formation
    (GO:0003198)
  • Epithelium development
    (GO:0060429)
  • Hematopoietic stem cell proliferation
    (GO:0071425)
  • Metal ion binding
    (GO:0046872)
  • Multicellular organism development
    (GO:0007275)
  • Myeloid cell apoptotic process
    (GO:0033028)
  • Negative regulation of anoikis
    (GO:2000811)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of cell adhesion involved in substrate-bound cell migration
    (GO:0006933)
  • Negative regulation of cell adhesion mediated by integrin
    (GO:0033629)
  • Negative regulation of chondrocyte differentiation
    (GO:0032331)
  • Negative regulation of dna damage response, signal transduction by p53 class mediator
    (GO:0043518)
  • Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
    (GO:2001240)
  • Negative regulation of hematopoietic stem cell proliferation
    (GO:1902034)
  • Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage
    (GO:1902230)
  • Negative regulation of keratinocyte proliferation
    (GO:0010839)
  • Negative regulation of myeloid cell apoptotic process
    (GO:0033033)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of vitamin d biosynthetic process
    (GO:0010957)
  • Negative regulation of vitamin d receptor signaling pathway
    (GO:0070563)
  • Neural crest cell development
    (GO:0014032)
  • Notch signaling pathway
    (GO:0007219)
  • Nucleus
    (GO:0005634)
  • Pigmentation
    (GO:0043473)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of endothelial cell chemotaxis
    (GO:2001028)
  • Positive regulation of fat cell differentiation
    (GO:0045600)
  • Protein binding
    (GO:0005515)
  • Regulation of apoptotic process
    (GO:0042981)
  • Regulation of bicellular tight junction assembly
    (GO:2000810)
  • Regulation of branching involved in salivary gland morphogenesis
    (GO:0060693)
  • Regulation of chemokine production
    (GO:0032642)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of osteoblast differentiation
    (GO:0045667)
  • Response to radiation
    (GO:0009314)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Roof of mouth development
    (GO:0060021)
  • Sensory perception of sound
    (GO:0007605)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Substrate-dependent cell migration
    (GO:0006929)
  • White fat cell differentiation
    (GO:0050872)
  • Wound healing, spreading of cells
    (GO:0044319)

Other Information

Genular Protein ID: 23627111

Symbol: SNAI2_MOUSE

Name: Zinc finger protein SNAI2

UniProtKB Accession Codes:

P97469 O09096 Q9R211

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 59 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 9182671

Title: The zinc-finger protein Slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition.

PubMed ID: 9182671

DOI: 10.1083/jcb.137.6.1403

PubMed ID: 9838149

Title: Genomic organization, expression and chromosomal localization of the mouse Slug (Slugh) gene.

PubMed ID: 9838149

DOI: 10.1016/s0167-4781(98)00225-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18331720

Title: Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus.

PubMed ID: 18331720

DOI: 10.1016/j.devcel.2008.01.005

Sequence Information:

  • Length: 269
  • Mass: 30003
  • Checksum: C61F57779251BEB0
  • Sequence:
    • MPRSFLVKKH FNASKKPNYS ELDTHTVIIS PYLYESYPIP VIPKPEILTS GAYSPITVWT 
SSAAPLHSPL PSGLSPLTGY SSSLGRVSPP PSSDTSSKDH SGSESPISDE EERLQPKLSD 
PHAIEAEKFQ CNLCNKTYST FSGLAKHKQL HCDAQSRKSF SCKYCDKEYV SLGALKMHIR 
THTLPCVCKI CGKAFSRPWL LQGHIRTHTG EKPFSCPHCN RAFADRSNLR AHLQTHSDVK 
KYQCKNCSKT FSRMSLLHKH EESGCCVAH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.