Genular: Defining Cellular Identity and Function

Details for: Smarca4

Gene ID: 20586

Symbol: Smarca4

Ensembl ID: ENSMUSG00000032187

Description: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

Associated with

Chromatin modifying enzymes
(R-MMU-3247509)
Cytokine signaling in immune system
(R-MMU-1280215)
Formation of the beta-catenin:tcf transactivating complex
(R-MMU-201722)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Immune system
(R-MMU-168256)
Interleukin-7 signaling
(R-MMU-1266695)
Rmts methylate histone arginines
(R-MMU-3214858)
Rna polymerase ii transcription
(R-MMU-73857)
Runx1 interacts with co-factors whose precise effect on runx1 targets is not known
(R-MMU-8939243)
Signaling by interleukins
(R-MMU-449147)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Transcriptional regulation by runx1
(R-MMU-8878171)
Aorta development
(GO:0035904)
Aortic smooth muscle cell differentiation
(GO:0035887)
Atp-dependent activity, acting on dna
(GO:0008094)
Atp-dependent chromatin remodeler activity
(GO:0140658)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Blastocyst growth
(GO:0001832)
Blastocyst hatching
(GO:0001835)
Blood vessel development
(GO:0001568)
Cell morphogenesis
(GO:0000902)
Chromatin binding
(GO:0003682)
Chromatin organization
(GO:0006325)
Chromatin remodeling
(GO:0006338)
Dna binding
(GO:0003677)
Dna methylation-dependent heterochromatin formation
(GO:0006346)
Dna polymerase binding
(GO:0070182)
Embryonic hindlimb morphogenesis
(GO:0035116)
Extracellular matrix organization
(GO:0030198)
Forebrain development
(GO:0030900)
Gene expression
(GO:0010467)
Glial cell fate determination
(GO:0007403)
Heart development
(GO:0007507)
Helicase activity
(GO:0004386)
Hindbrain development
(GO:0030902)
Histone binding
(GO:0042393)
Hydrolase activity
(GO:0016787)
In utero embryonic development
(GO:0001701)
Keratinocyte differentiation
(GO:0030216)
Liver development
(GO:0001889)
Lncrna binding
(GO:0106222)
Lysine-acetylated histone binding
(GO:0070577)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell differentiation
(GO:0045596)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nervous system development
(GO:0007399)
Neurogenesis
(GO:0022008)
Nuclear androgen receptor binding
(GO:0050681)
Nucleosome assembly
(GO:0006334)
Nucleosome disassembly
(GO:0006337)
Nucleotide binding
(GO:0000166)
Outflow tract morphogenesis
(GO:0003151)
P53 binding
(GO:0002039)
Positive regulation by host of viral transcription
(GO:0043923)
Positive regulation of cell differentiation
(GO:0045597)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of dna binding
(GO:0043388)
Positive regulation of myoblast differentiation
(GO:0045663)
Positive regulation of t cell differentiation
(GO:0045582)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of wnt signaling pathway
(GO:0030177)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Regulation of cell migration
(GO:0030334)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of mitotic metaphase/anaphase transition
(GO:0030071)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna binding
(GO:0003723)
Rna polymerase i core promoter sequence-specific dna binding
(GO:0001164)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Stem cell population maintenance
(GO:0019827)
Tat protein binding
(GO:0030957)
Transcription by rna polymerase ii
(GO:0006366)
Transcription coactivator activity
(GO:0003713)
Transcription coregulator binding
(GO:0001221)
Transcription corepressor activity
(GO:0003714)
Transcription factor binding
(GO:0008134)
Transcription initiation-coupled chromatin remodeling
(GO:0045815)
Vasculogenesis
(GO:0001570)
Ventricular septum development
(GO:0003281)

Other Information

Proteins

Transcription activator BRG1
A0A0R4J170_MOUSE

Genular Protein ID: 3841071919

Symbol: SMCA4_MOUSE

Name: Transcription activator BRG1

UniProtKB Accession Codes:

Q3TKT4 Q3TUD7 Q6AXG8

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17640523

Title: An essential switch in subunit composition of a chromatin remodeling complex during neural development.

PubMed ID: 17640523

DOI: 10.1016/j.neuron.2007.06.019

PubMed ID: 16424906

Title: Skeletal muscle specification by myogenin and Mef2D via the SWI/SNF ATPase Brg1.

PubMed ID: 16424906

DOI: 10.1038/sj.emboj.7600943

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21095589

Title: Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression.

PubMed ID: 21095589

DOI: 10.1016/j.molcel.2010.10.028

PubMed ID: 22162999

Title: SAF-A forms a complex with BRG1 and both components are required for RNA polymerase II mediated transcription.

PubMed ID: 22162999

DOI: 10.1371/journal.pone.0028049

PubMed ID: 22952240

Title: SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse functions.

PubMed ID: 22952240

DOI: 10.1074/jbc.r111.309302

PubMed ID: 26138476

Title: Evf2 lncRNA/BRG1/DLX1 interactions reveal RNA-dependent inhibition of chromatin remodeling.

PubMed ID: 26138476

DOI: 10.1242/dev.126318

PubMed ID: 26601204

Title: Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics.

PubMed ID: 26601204

DOI: 10.1126/sciadv.1500447

PubMed ID: 29374058

Title: Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes.

PubMed ID: 29374058

DOI: 10.1074/jbc.ra117.001065

PubMed ID: 32459350

Title: HRP2-DPF3a-BAF complex coordinates histone modification and chromatin remodeling to regulate myogenic gene transcription.

PubMed ID: 32459350

DOI: 10.1093/nar/gkaa441

PubMed ID: 34910916

Title: Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1.

PubMed ID: 34910916

DOI: 10.1016/j.celrep.2021.110104

Sequence Information:

Length: 1613
Mass: 181427
Checksum: C23804ED858F98FE
Sequence:

MSTPDPPLGG TPRPGPSPGP GPSPGAMLGP SPGPSPGSAH SMMGPSPGPP SAGHPMPTQG 
PGGYPQDNMH QMHKPMESMH EKGMPDDPRY NQMKGMGMRS GAHTGMAPPP SPMDQHSQGY 
PSPLGGSEHA SSPVPASGPS SGPQMSSGPG GAPLDGSDPQ ALGQQNRGPT PFNQNQLHQL 
RAQIMAYKML ARGQPLPDHL QMAVQGKRPM PGMQQQMPTL PPPSVSATGP GPGPGPGPGP 
GPGPAPPNYS RPHGMGGPNM PPPGPSGVPP GMPGQPPGGP PKPWPEGPMA NAAAPTSTPQ 
KLIPPQPTGR PSPAPPAVPP AASPVMPPQT QSPGQPAQPA PLVPLHQKQS RITPIQKPRG 
LDPVEILQER EYRLQARIAH RIQELENLPG SLAGDLRTKA TIELKALRLL NFQRQLRQEV 
VVCMRRDTAL ETALNAKAYK RSKRQSLREA RITEKLEKQQ KIEQERKRRQ KHQEYLNSIL 
QHAKDFREYH RSVTGKLQKL TKAVATYHAN TEREQKKENE RIEKERMRRL MAEDEEGYRK 
LIDQKKDKRL AYLLQQTDEY VANLTELVRQ HKAAQVAKEK KKKKKKKKAE NAEGQTPAIG 
PDGEPLDETS QMSDLPVKVI HVESGKILTG TDAPKAGQLE AWLEMNPGYE VAPRSDSEES 
GSEEEEEEEE EEQPQPAQPP TLPVEEKKKI PDPDSDDVSE VDARHIIENA KQDVDDEYGV 
SQALARGLQS YYAVAHAVTE RVDKQSALMV NGVLKQYQIK GLEWLVSLYN NNLNGILADE 
MGLGKTIQTI ALITYLMEHK RINGPFLIIV PLSTLSNWAY EFDKWAPSVV KVSYKGSPAA 
RRAFVPQLRS GKFNVLLTTY EYIIKDKHIL AKIRWKYMIV DEGHRMKNHH CKLTQVLNTH 
YVAPRRLLLT GTPLQNKLPE LWALLNFLLP TIFKSCSTFE QWFNAPFAMT GEKVDLNEEE 
TILIIRRLHK VLRPFLLRRL KKEVEAQLPE KVEYVIKCDM SALQRVLYRH MQAKGVLLTD 
GSEKDKKGKG GTKTLMNTIM QLRKICNHPY MFQHIEESFS EHLGFTGGIV QGLDLYRASG 
KFELLDRILP KLRATNHKVL LFCQMTSLMT IMEDYFAYRG FKYLRLDGTT KAEDRGMLLK 
TFNEPGSEYF IFLLSTRAGG LGLNLQSADT VIIFDSDWNP HQDLQAQDRA HRIGQQNEVR 
VLRLCTVNSV EEKILAAAKY KLNVDQKVIQ AGMFDQKSSS HERRAFLQAI LEHEEQDEEE 
DEVPDDETVN QMIARHEEEF DLFMRMDLDR RREEARNPKR KPRLMEEDEL PSWIIKDDAE 
VERLTCEEEE EKMFGRGSRH RKEVDYSDSL TEKQWLKAIE EGTLEEIEEE VRQKKSSRKR 
KRDSEAGSST PTTSTRSRDK DEESKKQKKR GRPPAEKLSP NPPNLTKKMK KIVDAVIKYK 
DSSGRQLSEV FIQLPSRKEL PEYYELIRKP VDFKKIKERI RNHKYRSLND LEKDVMLLCQ 
NAQTFNLEGS LIYEDSIVLQ SVFTSVRQKI EKEDDSEGEE SEEEEEGEEE GSESESRSVK 
VKIKLGRKEK AQDRLKGGRR RPSRGSRAKP VVSDDDSEEE QEEDRSGSGS EED

Genular Protein ID: 3252178483

Symbol: A0A0R4J170_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A0R4J170

Database IDs:

Citations:

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 1617
Mass: 181857
Checksum: 03434F6383B9017E
Sequence:

MSTPDPPLGG TPRPGPSPGP GPSPGAMLGP SPGPSPGSAH SMMGPSPGPP SAGHPMPTQG 
PGGYPQDNMH QMHKPMESMH EKGMPDDPRY NQMKGMGMRS GAHTGMAPPP SPMDQHSQGY 
PSPLGGSEHA SSPVPASGPS SGPQMSSGPG GAPLDGSDPQ ALGQQNRGPT PFNQNQLHQL 
RAQIMAYKML ARGQPLPDHL QMAVQGKRPM PGMQQQMPTL PPPSVSATGP GPGPGPGPGP 
GPGPAPPNYS RPHGMGGPNM PPPGPSGVPP GMPGQPPGGP PKPWPEGPMA NAAAPTSTPQ 
KLIPPQPTGR PSPAPPAVPP AASPVMPPQT QSPGQPAQPA PLVPLHQKQS RITPIQKPRG 
LDPVEILQER EYRLQARIAH RIQELENLPG SLAGDLRTKA TIELKALRLL NFQRQLRQEV 
VVCMRRDTAL ETALNAKAYK RSKRQSLREA RITEKLEKQQ KIEQERKRRQ KHQEYLNSIL 
QHAKDFREYH RSVTGKLQKL TKAVATYHAN TEREQKKENE RIEKERMRRL MAEDEEGYRK 
LIDQKKDKRL AYLLQQTDEY VANLTELVRQ HKAAQVAKEK KKKKKKKKAE NAEGQTPAIG 
PDGEPLDETS QMSDLPVKVI HVESGKILTG TDAPKAGQLE AWLEMNPGYE VAPRSDSEES 
GSEEEEEEEE EEQPQPAQPP TLPVEEKKKI PDPDSDDVSE VDARHIIENA KQDVDDEYGV 
SQALARGLQS YYAVAHAVTE RVDKQSALMV NGVLKQYQIK GLEWLVSLYN NNLNGILADE 
MGLGKTIQTI ALITYLMEHK RINGPFLIIV PLSTLSNWAY EFDKWAPSVV KVSYKGSPAA 
RRAFVPQLRS GKFNVLLTTY EYIIKDKHIL AKIRWKYMIV DEGHRMKNHH CKLTQVLNTH 
YVAPRRLLLT GTPLQNKLPE LWALLNFLLP TIFKSCSTFE QWFNAPFAMT GEKVDLNEEE 
TILIIRRLHK VLRPFLLRRL KKEVEAQLPE KVEYVIKCDM SALQRVLYRH MQAKGVLLTD 
GSEKDKKGKG GTKTLMNTIM QLRKICNHPY MFQHIEESFS EHLGFTGGIV QGLDLYRASG 
KFELLDRILP KLRATNHKVL LFCQMTSLMT IMEDYFAYRG FKYLRLDGTT KAEDRGMLLK 
TFNEPGSEYF IFLLSTRAGG LGLNLQSADT VIIFDSDWNP HQDLQAQDRA HRIGQQNEVR 
VLRLCTVNSV EEKILAAAKY KLNVDQKVIQ AGMFDQKSSS HERRAFLQAI LEHEEQDEEE 
DEVPDDETVN QMIARHEEEF DLFMRMDLDR RREEARNPKR KPRLMEEDEL PSWIIKDDAE 
VERLTCEEEE EKMFGRGSRH RKEVDYSDSL TEKQWLKTLK AIEEGTLEEI EEEVRQKKSS 
RKRKRDSEAG SSTPTTSTRS RDKDEESKKQ KKRGRPPAEK LSPNPPNLTK KMKKIVDAVI 
KYKDSSSGRQ LSEVFIQLPS RKELPEYYEL IRKPVDFKKI KERIRNHKYR SLNDLEKDVM 
LLCQNAQTFN LEGSLIYEDS IVLQSVFTSV RQKIEKEDDS EGEESEEEEE GEEEGSESES 
RSVKVKIKLG RKEKAQDRLK GGRRRPSRGS RAKPVVSDDD SEEEQEEDRS GSGSEED

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Smarca4

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

An essential switch in subunit composition of a chromatin remodeling complex during neural development. PubMed ID: 17640523

Skeletal muscle specification by myogenin and Mef2D via the SWI/SNF ATPase Brg1. PubMed ID: 16424906

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. PubMed ID: 21095589

SAF-A forms a complex with BRG1 and both components are required for RNA polymerase II mediated transcription. PubMed ID: 22162999

SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse functions. PubMed ID: 22952240

Evf2 lncRNA/BRG1/DLX1 interactions reveal RNA-dependent inhibition of chromatin remodeling. PubMed ID: 26138476

Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics. PubMed ID: 26601204

Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. PubMed ID: 29374058

HRP2-DPF3a-BAF complex coordinates histone modification and chromatin remodeling to regulate myogenic gene transcription. PubMed ID: 32459350

Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1. PubMed ID: 34910916

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Database document:

PubMed ID: 16141072

PubMed ID: 15489334

PubMed ID: 17640523

PubMed ID: 16424906

PubMed ID: 17242355

PubMed ID: 19144319

PubMed ID: 21183079

PubMed ID: 21095589

PubMed ID: 22162999

PubMed ID: 22952240

PubMed ID: 26138476

PubMed ID: 26601204

PubMed ID: 29374058

PubMed ID: 32459350

PubMed ID: 34910916

PubMed ID: 17242355

PubMed ID: 19144319

PubMed ID: 19468303

PubMed ID: 21183079