Genular: Defining Cellular Identity and Function

Details for: Smn1

Gene ID: 20595

Symbol: Smn1

Ensembl ID: ENSMUSG00000021645

Description: survival motor neuron 1

Associated with

Metabolism of non-coding rna
(R-MMU-194441)
Metabolism of rna
(R-MMU-8953854)
Snrnp assembly
(R-MMU-191859)
Axonogenesis
(GO:0007409)
Cajal body
(GO:0015030)
Cell projection
(GO:0042995)
Copi-coated vesicle
(GO:0030137)
Cytoplasm
(GO:0005737)
Cytoplasmic ribonucleoprotein granule
(GO:0036464)
Cytosol
(GO:0005829)
Fibroblast growth factor binding
(GO:0017134)
Gemini of coiled bodies
(GO:0097504)
Golgi apparatus
(GO:0005794)
Growth cone
(GO:0030426)
Identical protein binding
(GO:0042802)
Microtubule depolymerization
(GO:0007019)
Mrna processing
(GO:0006397)
Nervous system development
(GO:0007399)
Neuron projection
(GO:0043005)
Nuclear body
(GO:0016604)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Perikaryon
(GO:0043204)
Positive regulation of rna splicing
(GO:0033120)
Protein binding
(GO:0005515)
Regulation of neuron projection development
(GO:0010975)
Rna binding
(GO:0003723)
Rna splicing
(GO:0008380)
Smn-sm protein complex
(GO:0034719)
Smn complex
(GO:0032797)
Spliceosomal snrnp assembly
(GO:0000387)

Other Information

Proteins

Survival motor neuron protein

Genular Protein ID: 3696303216

Symbol: SMN_MOUSE

Name: Survival motor neuron protein

UniProtKB Accession Codes:

P97801 O09092

Database IDs:

Citations:

PubMed ID: 9070939

Title: cDNA isolation, expression, and chromosomal localization of the mouse survival motor neuron gene (Smn).

PubMed ID: 9070939

DOI: 10.1006/geno.1996.4551

PubMed ID: 9110173

Title: Cloning, characterization, and copy number of the murine survival motor neuron gene: homolog of the spinal muscular atrophy-determining gene.

PubMed ID: 9110173

DOI: 10.1101/gr.7.4.339

PubMed ID: 9275227

Title: Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos.

PubMed ID: 9275227

DOI: 10.1073/pnas.94.18.9920

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11773003

Title: Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons?

PubMed ID: 11773003

DOI: 10.1093/hmg/11.1.93

PubMed ID: 15345747

Title: Phosphoproteomic analysis of the developing mouse brain.

PubMed ID: 15345747

DOI: 10.1074/mcp.m400085-mcp200

PubMed ID: 17353360

Title: A Drosophila melanogaster model of spinal muscular atrophy reveals a function for SMN in striated muscle.

PubMed ID: 17353360

DOI: 10.1083/jcb.200610053

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21389246

Title: The survival of motor neuron (SMN) protein interacts with the mRNA-binding protein HuD and regulates localization of poly(A) mRNA in primary motor neuron axons.

PubMed ID: 21389246

DOI: 10.1523/jneurosci.3631-10.2011

PubMed ID: 23063131

Title: An SMN-dependent U12 splicing event essential for motor circuit function.

PubMed ID: 23063131

DOI: 10.1016/j.cell.2012.09.012

Sequence Information:

Length: 288
Mass: 31254
Checksum: 757B3074649F7458
Sequence:

MAMGSGGAGS EQEDTVLFRR GTGQSDDSDI WDDTALIKAY DKAVASFKHA LKNGDICETP 
DKPKGTARRK PAKKNKSQKK NATTPLKQWK VGDKCSAVWS EDGCIYPATI TSIDFKRETC 
VVVYTGYGNR EEQNLSDLLS PTCEVANSTE QNTQENESQV STDDSEHSSR SLRSKAHSKS 
KAAPWTSFLP PPPPMPGSGL GPGKPGLKFN GPPPPPPLPP PPFLPCWMPP FPSGPPIIPP 
PPPISPDCLD DTDALGSMLI SWYMSGYHTG YYMGFRQNKK EGKCSHTN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Smn1

Associated with

Other Information

cDNA isolation, expression, and chromosomal localization of the mouse survival motor neuron gene (Smn). PubMed ID: 9070939

Cloning, characterization, and copy number of the murine survival motor neuron gene: homolog of the spinal muscular atrophy-determining gene. PubMed ID: 9110173

Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos. PubMed ID: 9275227

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons? PubMed ID: 11773003

Phosphoproteomic analysis of the developing mouse brain. PubMed ID: 15345747

A Drosophila melanogaster model of spinal muscular atrophy reveals a function for SMN in striated muscle. PubMed ID: 17353360

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The survival of motor neuron (SMN) protein interacts with the mRNA-binding protein HuD and regulates localization of poly(A) mRNA in primary motor neuron axons. PubMed ID: 21389246

An SMN-dependent U12 splicing event essential for motor circuit function. PubMed ID: 23063131