Genular: Defining Cellular Identity and Function

Details for: Smpd1

Gene ID: 20597

Symbol: Smpd1

Ensembl ID: ENSMUSG00000037049

Description: sphingomyelin phosphodiesterase 1, acid lysosomal

Associated with

Glycosphingolipid catabolism
(R-MMU-9840310)
Glycosphingolipid metabolism
(R-MMU-1660662)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Sphingolipid metabolism
(R-MMU-428157)
Acid sphingomyelin phosphodiesterase activity
(GO:0061750)
Cellular response to calcium ion
(GO:0071277)
Cellular response to uv
(GO:0034644)
Ceramide biosynthetic process
(GO:0046513)
Ceramide metabolic process
(GO:0006672)
Cholesterol metabolic process
(GO:0008203)
Endolysosome
(GO:0036019)
Endosome
(GO:0005768)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Hydrolase activity
(GO:0016787)
Hydrolase activity, acting on glycosyl bonds
(GO:0016798)
Lamellar body
(GO:0042599)
Lipid droplet
(GO:0005811)
Lipid metabolic process
(GO:0006629)
Lysosome
(GO:0005764)
Metabolic process
(GO:0008152)
Metal ion binding
(GO:0046872)
Negative regulation of map kinase activity
(GO:0043407)
Phosphatidylcholine phospholipase c activity
(GO:0034480)
Plasma membrane
(GO:0005886)
Plasma membrane repair
(GO:0001778)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of endocytosis
(GO:0045807)
Positive regulation of protein dephosphorylation
(GO:0035307)
Positive regulation of viral entry into host cell
(GO:0046598)
Response to cocaine
(GO:0042220)
Response to interleukin-1
(GO:0070555)
Response to ionizing radiation
(GO:0010212)
Response to tumor necrosis factor
(GO:0034612)
Response to type i interferon
(GO:0034340)
Response to virus
(GO:0009615)
Sphingomyelin catabolic process
(GO:0006685)
Sphingomyelin phosphodiesterase activity
(GO:0004767)
Symbiont entry into host cell
(GO:0046718)
Termination of signal transduction
(GO:0023021)
Wound healing
(GO:0042060)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Sphingomyelin phosphodiesterase

Genular Protein ID: 712661105

Symbol: ASM_MOUSE

Name: Sphingomyelin phosphodiesterase

UniProtKB Accession Codes:

Q04519 Q3UL52

Database IDs:

Citations:

PubMed ID: 1292508

Title: Molecular cloning of the acid sphingomyelinase of the mouse and the organization and complete nucleotide sequence of the gene.

PubMed ID: 1292508

DOI: 10.1515/bchm3.1992.373.2.1233

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706124

Title: Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis.

PubMed ID: 8706124

DOI: 10.1016/s0092-8674(00)80091-4

PubMed ID: 8702487

Title: Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene.

PubMed ID: 8702487

DOI: 10.1074/jbc.271.31.18431

PubMed ID: 9660788

Title: The cellular trafficking and zinc dependence of secretory and lysosomal sphingomyelinase, two products of the acid sphingomyelinase gene.

PubMed ID: 9660788

DOI: 10.1074/jbc.273.29.18250

PubMed ID: 12563314

Title: Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts.

PubMed ID: 12563314

DOI: 10.1038/nm823

PubMed ID: 35705808

Title: Caspase-7 activates ASM to repair gasdermin and perforin pores.

PubMed ID: 35705808

DOI: 10.1038/s41586-022-04825-8

PubMed ID: 27435900

Title: Crystal structure of mammalian acid sphingomyelinase.

PubMed ID: 27435900

DOI: 10.1038/ncomms12196

Sequence Information:

Length: 627
Mass: 69927
Checksum: 0FFC7EA74EE71E91
Sequence:

MPHHRASSGQ DHLRAGWEQR LERSLPAPRV GLLWMGLGLA LVLALFDSTV LWVPARAYPL 
PSEGHSVKFS AIAPPLQSAF GWQNLTCPAC KVLFTALNHG LKKEPNVARV GSVAIKICKM 
LNIAPLDVCQ SAVHLFEDDV VEVWTRSVLS PSEACGLLLG SSCGHWDIFS TWNISLPSVP 
KPPPKPPSPP APGAPVSRVL FLTDLHWDHE YLEGTDPYCA DPLCCRRGSG WPPNSQKGAG 
FWGEYSKCDL PLRTLESLLK GLGPAGPFEM VYWTGDIPAH DVWQQSRQDQ LRALTTITDL 
VRKFLGPVPV YPAVGNHEST PVNGFPPPFI KGNQSSQWLY EAMAKAWEPW LPADALHTLR 
IGGFYALTPR PGLRLISLNM NFCSRENFWL LINSTDPAGQ LQWLVEELQA AENRGDKVHI 
IGHIPPGHCL KSWSWNYYKI IARYENTLAG QFFGHTHVDE FEIFYDEETL SRPLAVAFLA 
PSATTFINLN PGYRVYQIDG NYPGSSHVVL DHETYILNLT QANAAGGTPS WKRLYRARET 
YGLPDAMPAS WHNLVYRMRD DEQLFQTFWF LYHKGHPPSE PCGTPCRLAT LCAQLSARAD 
SPALCRHLMP NGSLPDANRL WSRPLLC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Smpd1

Associated with

Other Information

Molecular cloning of the acid sphingomyelinase of the mouse and the organization and complete nucleotide sequence of the gene. PubMed ID: 1292508

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. PubMed ID: 8706124

Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene. PubMed ID: 8702487

The cellular trafficking and zinc dependence of secretory and lysosomal sphingomyelinase, two products of the acid sphingomyelinase gene. PubMed ID: 9660788

Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts. PubMed ID: 12563314

Caspase-7 activates ASM to repair gasdermin and perforin pores. PubMed ID: 35705808

Crystal structure of mammalian acid sphingomyelinase. PubMed ID: 27435900