Details for: Snai1

Gene ID: 20613

Symbol: Snai1

Ensembl ID: ENSMUSG00000042821

Description: snail family zinc finger 1

Associated with

  • Canonical wnt signaling pathway
    (GO:0060070)
  • Cartilage morphogenesis
    (GO:0060536)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • E-box binding
    (GO:0070888)
  • Epithelial cell migration
    (GO:0010631)
  • Epithelial to mesenchymal transition
    (GO:0001837)
  • Epithelial to mesenchymal transition involved in endocardial cushion formation
    (GO:0003198)
  • Fibrillar center
    (GO:0001650)
  • Hair follicle morphogenesis
    (GO:0031069)
  • Heterochromatin organization
    (GO:0070828)
  • Intracellular membrane-bounded organelle
    (GO:0043231)
  • Kinase binding
    (GO:0019900)
  • Left/right pattern formation
    (GO:0060972)
  • Mesoderm development
    (GO:0007498)
  • Mesoderm formation
    (GO:0001707)
  • Metal ion binding
    (GO:0046872)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of cell differentiation involved in embryonic placenta development
    (GO:0060806)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of dna damage response, signal transduction by p53 class mediator
    (GO:0043518)
  • Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage
    (GO:1902230)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of vitamin d biosynthetic process
    (GO:0010957)
  • Notch signaling pathway
    (GO:0007219)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Pericentric heterochromatin
    (GO:0005721)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of epithelial to mesenchymal transition
    (GO:0010718)
  • Protein binding
    (GO:0005515)
  • Regulation of bicellular tight junction assembly
    (GO:2000810)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Roof of mouth development
    (GO:0060021)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Trophoblast giant cell differentiation
    (GO:0060707)

Other Information

Genular Protein ID: 2530368546

Symbol: SNAI1_MOUSE

Name: Zinc finger protein SNAI1

UniProtKB Accession Codes:

Q02085

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 41 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 1295727

Title: Isolation of Sna, a mouse gene homologous to the Drosophila genes snail and escargot: its expression pattern suggests multiple roles during postimplantation development.

PubMed ID: 1295727

DOI: 10.1242/dev.116.4.1033

PubMed ID: 1483390

Title: Cloning and developmental expression of Sna, a murine homologue of the Drosophila snail gene.

PubMed ID: 1483390

DOI: 10.1242/dev.116.1.227

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9271672

Title: Genomic organization and chromosomal localization of the mouse snail (Sna) gene.

PubMed ID: 9271672

DOI: 10.1007/s003359900537

PubMed ID: 10655586

Title: The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression.

PubMed ID: 10655586

DOI: 10.1038/35000025

PubMed ID: 11689706

Title: The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition.

PubMed ID: 11689706

DOI: 10.1128/mcb.21.23.8184-8188.2001

PubMed ID: 12832491

Title: Phosphorylation regulates the subcellular location and activity of the snail transcriptional repressor.

PubMed ID: 12832491

DOI: 10.1128/mcb.23.14.5078-5089.2003

PubMed ID: 18331720

Title: Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus.

PubMed ID: 18331720

DOI: 10.1016/j.devcel.2008.01.005

PubMed ID: 19386897

Title: Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors.

PubMed ID: 19386897

DOI: 10.1242/jcs.041749

PubMed ID: 19955572

Title: The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation.

PubMed ID: 19955572

DOI: 10.1074/jbc.m109.065995

PubMed ID: 19923321

Title: Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A.

PubMed ID: 19923321

DOI: 10.1091/mbc.e09-06-0504

PubMed ID: 21577210

Title: Poly(ADP-ribose)-dependent regulation of Snail1 protein stability.

PubMed ID: 21577210

DOI: 10.1038/onc.2011.153

PubMed ID: 24239292

Title: Regulation of heterochromatin transcription by Snail1/LOXL2 during epithelial-to-mesenchymal transition.

PubMed ID: 24239292

DOI: 10.1016/j.molcel.2013.10.015

Sequence Information:

  • Length: 264
  • Mass: 29190
  • Checksum: 52E2061224A18DEB
  • Sequence:
    • MPRSFLVRKP SDPRRKPNYS ELQDACVEFT FQQPYDQAHL LAAIPPPEVL NPAASLPTLI 
WDSLLVPQVR PVAWATLPLR ESPKAVELTS LSDEDSGKSS QPPSPPSPAP SSFSSTSASS 
LEAEAFIAFP GLGQLPKQLA RLSVAKDPQS RKIFNCKYCN KEYLSLGALK MHIRSHTLPC 
VCTTCGKAFS RPWLLQGHVR THTGEKPFSC SHCNRAFADR SNLRAHLQTH SDVKRYQCQA 
CARTFSRMSL LHKHQESGCS GGPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.