Genular: Defining Cellular Identity and Function

Details for: Snap25

Gene ID: 20614

Symbol: Snap25

Ensembl ID: ENSMUSG00000027273

Description: synaptosomal-associated protein 25

Associated with

Acetylcholine neurotransmitter release cycle
(R-MMU-264642)
Cytokine signaling in immune system
(R-MMU-1280215)
Dopamine neurotransmitter release cycle
(R-MMU-212676)
Gaba synthesis, release, reuptake and degradation
(R-MMU-888590)
Glutamate neurotransmitter release cycle
(R-MMU-210500)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Neuronal system
(R-MMU-112316)
Neurotransmitter release cycle
(R-MMU-112310)
Neutrophil degranulation
(R-MMU-6798695)
Norepinephrine neurotransmitter release cycle
(R-MMU-181430)
Other interleukin signaling
(R-MMU-449836)
Serotonin neurotransmitter release cycle
(R-MMU-181429)
Signaling by interleukins
(R-MMU-449147)
Transmission across chemical synapses
(R-MMU-112315)
Actin cytoskeleton
(GO:0015629)
Associative learning
(GO:0008306)
Axon
(GO:0030424)
Axonal growth cone
(GO:0044295)
Bloc-1 complex
(GO:0031083)
Calcium-dependent protein binding
(GO:0048306)
Calcium ion-regulated exocytosis of neurotransmitter
(GO:0048791)
Cell cortex
(GO:0005938)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Endosomal transport
(GO:0016197)
Endosome
(GO:0005768)
Establishment of localization in cell
(GO:0051649)
Exocytic insertion of neurotransmitter receptor to postsynaptic membrane
(GO:0098967)
Exocytosis
(GO:0006887)
Extrinsic component of presynaptic membrane
(GO:0098888)
Filopodium
(GO:0030175)
Glutamatergic synapse
(GO:0098978)
Growth cone
(GO:0030426)
Insulin secretion
(GO:0030073)
Lamellipodium
(GO:0030027)
Lipid binding
(GO:0008289)
Locomotory behavior
(GO:0007626)
Long-term memory
(GO:0007616)
Long-term synaptic potentiation
(GO:0060291)
Membrane
(GO:0016020)
Myelin sheath
(GO:0043209)
Myosin binding
(GO:0017022)
Neuronal cell body
(GO:0043025)
Neuron projection
(GO:0043005)
Neurotransmitter receptor internalization
(GO:0099590)
Neurotransmitter secretion
(GO:0007269)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of hormone secretion
(GO:0046887)
Postsynapse
(GO:0098794)
Presynapse
(GO:0098793)
Presynaptic active zone membrane
(GO:0048787)
Presynaptic dense core vesicle exocytosis
(GO:0099525)
Presynaptic membrane
(GO:0042734)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Regulation of establishment of protein localization
(GO:0070201)
Regulation of neuron projection development
(GO:0010975)
Ribbon synapse
(GO:0097470)
Snap receptor activity
(GO:0005484)
Snare binding
(GO:0000149)
Snare complex
(GO:0031201)
Snare complex assembly
(GO:0035493)
Somatodendritic compartment
(GO:0036477)
Synapse
(GO:0045202)
Synaptic vesicle
(GO:0008021)
Synaptic vesicle exocytosis
(GO:0016079)
Synaptic vesicle fusion to presynaptic active zone membrane
(GO:0031629)
Synaptic vesicle priming
(GO:0016082)
Synaptobrevin 2-snap-25-syntaxin-1a-complexin i complex
(GO:0070032)
Synaptobrevin 2-snap-25-syntaxin-1a-complexin ii complex
(GO:0070033)
Synaptobrevin 2-snap-25-syntaxin-1a complex
(GO:0070044)
Syntaxin-1 binding
(GO:0017075)
Trans-golgi network
(GO:0005802)
Transmembrane transporter binding
(GO:0044325)
Vesicle
(GO:0031982)
Voltage-gated potassium channel activity
(GO:0005249)
Voltage-gated potassium channel complex
(GO:0008076)

Other Information

Proteins

Synaptosomal-associated protein 25

Genular Protein ID: 1362609445

Symbol: SNP25_MOUSE

Name: Synaptosomal-associated protein 25

UniProtKB Accession Codes:

P60879 A2AIC2 A2AIC3 P13795 P36974 P70557 P70558 Q8IXK3 Q96FM2 Q9BR45

Database IDs:

Citations:

PubMed ID: 2592413

Title: The identification of a novel synaptosomal-associated protein, SNAP-25, differentially expressed by neuronal subpopulations.

PubMed ID: 2592413

DOI: 10.1083/jcb.109.6.3039

PubMed ID: 11471062

Title: High-throughput sequence identification of gene coding variants within alcohol-related QTLs.

PubMed ID: 11471062

DOI: 10.1007/s00335-001-1001-x

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8243676

Title: Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds.

PubMed ID: 8243676

DOI: 10.1016/0014-5793(93)80448-4

PubMed ID: 9349529

Title: Characterization of the palmitoylation domain of SNAP-25.

PubMed ID: 9349529

DOI: 10.1046/j.1471-4159.1997.69051864.x

PubMed ID: 8103915

Title: Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25.

PubMed ID: 8103915

DOI: 10.1038/365160a0

PubMed ID: 10413679

Title: Functional characterisation of tetanus and botulinum neurotoxins binding domains.

PubMed ID: 10413679

DOI: 10.1242/jcs.112.16.2715

PubMed ID: 10195194

Title: Snapin: a SNARE-associated protein implicated in synaptic transmission.

PubMed ID: 10195194

DOI: 10.1038/5673

PubMed ID: 12459461

Title: Differential phosphorylation of SNAP-25 in vivo by protein kinase C and protein kinase A.

PubMed ID: 12459461

DOI: 10.1016/s0014-5793(02)03629-3

PubMed ID: 15466855

Title: SV2B regulates synaptotagmin 1 by direct interaction.

PubMed ID: 15466855

DOI: 10.1074/jbc.m407502200

PubMed ID: 17055430

Title: Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse.

PubMed ID: 17055430

DOI: 10.1016/j.cell.2006.08.040

PubMed ID: 16672379

Title: CytLEK1 is a regulator of plasma membrane recycling through its interaction with SNAP-25.

PubMed ID: 16672379

DOI: 10.1091/mbc.e05-12-1127

PubMed ID: 19196426

Title: Sept8 controls the binding of vesicle-associated membrane protein 2 to synaptophysin.

PubMed ID: 19196426

DOI: 10.1111/j.1471-4159.2008.05849.x

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 19285662

Title: Acrosome formation-associated factor is involved in fertilization.

PubMed ID: 19285662

DOI: 10.1016/j.fertnstert.2009.01.067

PubMed ID: 19546860

Title: The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth.

PubMed ID: 19546860

DOI: 10.1038/mp.2009.58

PubMed ID: 20798282

Title: Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.

PubMed ID: 20798282

DOI: 10.1126/science.1195227

PubMed ID: 20847230

Title: A charged prominence in the linker domain of the cysteine-string protein Cspalpha mediates its regulated interaction with the calcium sensor synaptotagmin 9 during exocytosis.

PubMed ID: 20847230

DOI: 10.1096/fj.09-152033

PubMed ID: 22832103

Title: Mutations in the gene PRRT2 cause paroxysmal kinesigenic dyskinesia with infantile convulsions.

PubMed ID: 22832103

DOI: 10.1016/j.celrep.2011.11.001

PubMed ID: 23341457

Title: PRIP (phospholipase C-related but catalytically inactive protein) inhibits exocytosis by direct interactions with syntaxin 1 and SNAP-25 through its C2 domain.

PubMed ID: 23341457

DOI: 10.1074/jbc.m112.419317

PubMed ID: 25253725

Title: The Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activity.

PubMed ID: 25253725

DOI: 10.1091/mbc.e14-06-1169

PubMed ID: 26198635

Title: Identification of a novel sequence motif recognized by the ankyrin repeat domain of zDHHC17/13 S-acyltransferases.

PubMed ID: 26198635

DOI: 10.1074/jbc.m115.657668

PubMed ID: 26406599

Title: SNAREs Interact with Retinal Degeneration Slow and Rod Outer Segment Membrane Protein-1 during Conventional and Unconventional Outer Segment Targeting.

PubMed ID: 26406599

DOI: 10.1371/journal.pone.0138508

PubMed ID: 27052163

Title: PRRT2 Is a Key Component of the Ca(2+)-Dependent Neurotransmitter Release Machinery.

PubMed ID: 27052163

DOI: 10.1016/j.celrep.2016.03.005

PubMed ID: 28821673

Title: UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans.

PubMed ID: 28821673

DOI: 10.1523/jneurosci.0338-17.2017

PubMed ID: 29056747

Title: PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptic transmission in cerebellum.

PubMed ID: 29056747

DOI: 10.1038/cr.2017.128

PubMed ID: 9731768

Title: The synaptic SNARE complex is a parallel four-stranded helical bundle.

PubMed ID: 9731768

DOI: 10.1038/1799

Sequence Information:

Length: 206
Mass: 23315
Checksum: FBED2B082A4CB6A6
Sequence:

MAEDADMRNE LEEMQRRADQ LADESLESTR RMLQLVEESK DAGIRTLVML DEQGEQLERI 
EEGMDQINKD MKEAEKNLTD LGKFCGLCVC PCNKLKSSDA YKKAWGNNQD GVVASQPARV 
VDEREQMAIS GGFIRRVTND ARENEMDENL EQVSGIIGNL RHMALDMGNE IDTQNRQIDR 
IMEKADSNKT RIDEANQRAT KMLGSG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Snap25

Associated with

Other Information

The identification of a novel synaptosomal-associated protein, SNAP-25, differentially expressed by neuronal subpopulations. PubMed ID: 2592413

High-throughput sequence identification of gene coding variants within alcohol-related QTLs. PubMed ID: 11471062

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds. PubMed ID: 8243676

Characterization of the palmitoylation domain of SNAP-25. PubMed ID: 9349529

Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25. PubMed ID: 8103915

Functional characterisation of tetanus and botulinum neurotoxins binding domains. PubMed ID: 10413679

Snapin: a SNARE-associated protein implicated in synaptic transmission. PubMed ID: 10195194

Differential phosphorylation of SNAP-25 in vivo by protein kinase C and protein kinase A. PubMed ID: 12459461

SV2B regulates synaptotagmin 1 by direct interaction. PubMed ID: 15466855

Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse. PubMed ID: 17055430

CytLEK1 is a regulator of plasma membrane recycling through its interaction with SNAP-25. PubMed ID: 16672379

Sept8 controls the binding of vesicle-associated membrane protein 2 to synaptophysin. PubMed ID: 19196426

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Acrosome formation-associated factor is involved in fertilization. PubMed ID: 19285662

The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth. PubMed ID: 19546860

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. PubMed ID: 20798282

A charged prominence in the linker domain of the cysteine-string protein Cspalpha mediates its regulated interaction with the calcium sensor synaptotagmin 9 during exocytosis. PubMed ID: 20847230

Mutations in the gene PRRT2 cause paroxysmal kinesigenic dyskinesia with infantile convulsions. PubMed ID: 22832103

PRIP (phospholipase C-related but catalytically inactive protein) inhibits exocytosis by direct interactions with syntaxin 1 and SNAP-25 through its C2 domain. PubMed ID: 23341457

The Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activity. PubMed ID: 25253725

Identification of a novel sequence motif recognized by the ankyrin repeat domain of zDHHC17/13 S-acyltransferases. PubMed ID: 26198635

SNAREs Interact with Retinal Degeneration Slow and Rod Outer Segment Membrane Protein-1 during Conventional and Unconventional Outer Segment Targeting. PubMed ID: 26406599

PRRT2 Is a Key Component of the Ca(2+)-Dependent Neurotransmitter Release Machinery. PubMed ID: 27052163

UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans. PubMed ID: 28821673

PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptic transmission in cerebellum. PubMed ID: 29056747

The synaptic SNARE complex is a parallel four-stranded helical bundle. PubMed ID: 9731768