Genular: Defining Cellular Identity and Function

Details for: Snca

Gene ID: 20617

Symbol: Snca

Ensembl ID: ENSMUSG00000025889

Description: synuclein, alpha

Associated with

Antiviral mechanism by ifn-stimulated genes
(R-MMU-1169410)
Cytokine signaling in immune system
(R-MMU-1280215)
Immune system
(R-MMU-168256)
Interferon signaling
(R-MMU-913531)
Pkr-mediated signaling
(R-MMU-9833482)
Actin binding
(GO:0003779)
Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Adult locomotory behavior
(GO:0008344)
Alpha-tubulin binding
(GO:0043014)
Arachidonic acid binding
(GO:0050544)
Behavioral response to cocaine
(GO:0048148)
Beta-tubulin binding
(GO:0048487)
Calcium ion binding
(GO:0005509)
Cellular response to oxidative stress
(GO:0034599)
Chemical synaptic transmission
(GO:0007268)
Copper ion binding
(GO:0005507)
Cuprous ion binding
(GO:1903136)
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process
(GO:0043027)
Dopamine biosynthetic process
(GO:0042416)
Dopamine metabolic process
(GO:0042417)
Dynein complex binding
(GO:0070840)
Enzyme binding
(GO:0019899)
Fatty acid metabolic process
(GO:0006631)
Ferrous iron binding
(GO:0008198)
Histone binding
(GO:0042393)
Hsp70 protein binding
(GO:0030544)
Identical protein binding
(GO:0042802)
Kinesin binding
(GO:0019894)
Lipid binding
(GO:0008289)
Magnesium ion binding
(GO:0000287)
Metal ion binding
(GO:0046872)
Microglial cell activation
(GO:0001774)
Microtubule binding
(GO:0008017)
Mitochondrial atp synthesis coupled electron transport
(GO:0042775)
Mitochondrial membrane organization
(GO:0007006)
Molecular adaptor activity
(GO:0060090)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043154)
Negative regulation of dopamine metabolic process
(GO:0045963)
Negative regulation of exocytosis
(GO:0045920)
Negative regulation of microtubule polymerization
(GO:0031115)
Negative regulation of monooxygenase activity
(GO:0032769)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of platelet-derived growth factor receptor signaling pathway
(GO:0010642)
Negative regulation of protein phosphorylation
(GO:0001933)
Negative regulation of transporter activity
(GO:0032410)
Neurotransmitter secretion
(GO:0007269)
Neutral lipid metabolic process
(GO:0006638)
Oxidoreductase activity
(GO:0016491)
Phospholipase binding
(GO:0043274)
Phospholipid binding
(GO:0005543)
Phospholipid metabolic process
(GO:0006644)
Phosphoprotein binding
(GO:0051219)
Positive regulation of endocytosis
(GO:0045807)
Positive regulation of exocytosis
(GO:0045921)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of neurotransmitter secretion
(GO:0001956)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of receptor recycling
(GO:0001921)
Positive regulation of snare complex assembly
(GO:0035543)
Positive regulation of synaptic transmission
(GO:0050806)
Protein binding
(GO:0005515)
Protein destabilization
(GO:0031648)
Protein domain specific binding
(GO:0019904)
Receptor internalization
(GO:0031623)
Regulation of dopamine secretion
(GO:0014059)
Regulation of glutamate secretion
(GO:0014048)
Regulation of locomotion
(GO:0040012)
Regulation of long-term neuronal synaptic plasticity
(GO:0048169)
Regulation of macrophage activation
(GO:0043030)
Regulation of neuronal synaptic plasticity
(GO:0048168)
Regulation of neuron apoptotic process
(GO:0043523)
Regulation of neurotransmitter secretion
(GO:0046928)
Regulation of phospholipase activity
(GO:0010517)
Regulation of transmembrane transporter activity
(GO:0022898)
Response to iron(ii) ion
(GO:0010040)
Response to lipopolysaccharide
(GO:0032496)
Response to magnesium ion
(GO:0032026)
Response to type ii interferon
(GO:0034341)
Response to xenobiotic stimulus
(GO:0009410)
Snare binding
(GO:0000149)
Snare complex assembly
(GO:0035493)
Synapse organization
(GO:0050808)
Synaptic transmission, dopaminergic
(GO:0001963)
Synaptic vesicle endocytosis
(GO:0048488)
Synaptic vesicle exocytosis
(GO:0016079)
Synaptic vesicle priming
(GO:0016082)
Synaptic vesicle transport
(GO:0048489)
Tau protein binding
(GO:0048156)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Alpha-synuclein

Genular Protein ID: 1810600044

Symbol: SYUA_MOUSE

Name: Alpha-synuclein

UniProtKB Accession Codes:

O55042 Q3U130 Q9CXF8 Q9EQC3 Q9QUR3

Database IDs:

Citations:

PubMed ID: 9648883

Title: Expression pattern of synucleins (non-Abeta component of Alzheimer's disease amyloid precursor protein/alpha-synuclein) during murine brain development.

PubMed ID: 9648883

DOI: 10.1046/j.1471-4159.1998.71010338.x

PubMed ID: 9601701

Title: The cDNA cloning and ontogeny of mouse alpha-synuclein.

PubMed ID: 9601701

DOI: 10.1097/00001756-199804200-00051

PubMed ID: 11156617

Title: Human and mouse alpha-synuclein genes: comparative genomic sequence analysis and identification of a novel gene regulatory element.

PubMed ID: 11156617

DOI: 10.1101/gr.165801

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12732244

Title: Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice.

PubMed ID: 12732244

DOI: 10.1016/s0306-4522(03)00036-8

PubMed ID: 10707987

Title: Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system.

PubMed ID: 10707987

DOI: 10.1016/s0896-6273(00)80886-7

PubMed ID: 17296554

Title: Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity.

PubMed ID: 17296554

DOI: 10.1016/j.neuron.2007.01.019

PubMed ID: 19004816

Title: Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system.

PubMed ID: 19004816

DOI: 10.1074/jbc.c800206200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20798282

Title: Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.

PubMed ID: 20798282

DOI: 10.1126/science.1195227

PubMed ID: 25246573

Title: alpha-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation.

PubMed ID: 25246573

DOI: 10.1073/pnas.1416598111

PubMed ID: 31034892

Title: Increased Aggregation Tendency of Alpha-Synuclein in a Fully Disordered Protein Complex.

PubMed ID: 31034892

DOI: 10.1016/j.jmb.2019.04.031

Sequence Information:

Length: 140
Mass: 14485
Checksum: 1FFD19D7E15E636C
Sequence:

MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK 
EQVTNVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDQM GKGEEGYPQE GILEDMPVDP 
GSEAYEMPSE EGYQDYEPEA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Snca

Associated with

Other Information

Expression pattern of synucleins (non-Abeta component of Alzheimer's disease amyloid precursor protein/alpha-synuclein) during murine brain development. PubMed ID: 9648883

The cDNA cloning and ontogeny of mouse alpha-synuclein. PubMed ID: 9601701

Human and mouse alpha-synuclein genes: comparative genomic sequence analysis and identification of a novel gene regulatory element. PubMed ID: 11156617

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice. PubMed ID: 12732244

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. PubMed ID: 10707987

Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity. PubMed ID: 17296554

Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system. PubMed ID: 19004816

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. PubMed ID: 20798282

alpha-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation. PubMed ID: 25246573

Increased Aggregation Tendency of Alpha-Synuclein in a Fully Disordered Protein Complex. PubMed ID: 31034892