Genular: Defining Cellular Identity and Function

Details for: Plk2

Gene ID: 20620

Symbol: Plk2

Ensembl ID: ENSMUSG00000021701

Description: polo like kinase 2

Associated with

Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Rna polymerase ii transcription
(R-MMU-73857)
Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
(R-MMU-6804115)
Tp53 regulates transcription of cell cycle genes
(R-MMU-6791312)
Transcriptional regulation by tp53
(R-MMU-3700989)
Atp-dependent protein binding
(GO:0043008)
Atpase binding
(GO:0051117)
Atp binding
(GO:0005524)
Cell projection
(GO:0042995)
Centriole
(GO:0005814)
Centrosome
(GO:0005813)
Chromatin
(GO:0000785)
Clathrin heavy chain binding
(GO:0032050)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Dendrite
(GO:0030425)
G1/s transition of mitotic cell cycle
(GO:0000082)
Gtpase binding
(GO:0051020)
Kinase activity
(GO:0016301)
Kinetochore
(GO:0000776)
Long-term synaptic depression
(GO:0060292)
Long-term synaptic potentiation
(GO:0060291)
Memory
(GO:0007613)
Mitotic cell cycle
(GO:0000278)
Mitotic spindle organization
(GO:0007052)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of apoptotic process in bone marrow cell
(GO:0071866)
Negative regulation of cellular senescence
(GO:2000773)
Negative regulation of dendritic spine development
(GO:0061000)
Negative regulation of excitatory postsynaptic potential
(GO:0090394)
Negative regulation of protein localization to cell surface
(GO:2000009)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Peptidyl-serine phosphorylation
(GO:0018105)
Phosphorylation
(GO:0016310)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of cell migration involved in sprouting angiogenesis
(GO:0090050)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of protein catabolic process
(GO:0045732)
Positive regulation of receptor internalization
(GO:0002092)
Protein-containing complex binding
(GO:0044877)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Rap protein signal transduction
(GO:0032486)
Ras protein signal transduction
(GO:0007265)
Regulation of centriole replication
(GO:0046599)
Regulation of synaptic plasticity
(GO:0048167)
Spindle pole
(GO:0000922)
Transferase activity
(GO:0016740)

Other Information

Proteins

Serine/threonine-protein kinase PLK2
Q3TV29_MOUSE

Genular Protein ID: 3092163756

Symbol: PLK2_MOUSE

Name: Serine/threonine-protein kinase PLK2

UniProtKB Accession Codes:

P53351

Database IDs:

Citations:

PubMed ID: 1508211

Title: Identification of an early-growth-response gene encoding a novel putative protein kinase.

PubMed ID: 1508211

DOI: 10.1128/mcb.12.9.4164-4169.1992

PubMed ID: 12651910

Title: The serum-inducible protein kinase Snk is a G1 phase polo-like kinase that is inhibited by the calcium- and integrin-binding protein CIB.

PubMed ID: 12651910

PubMed ID: 12897130

Title: Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells.

PubMed ID: 12897130

DOI: 10.1128/mcb.23.16.5556-5571.2003

PubMed ID: 12972611

Title: Role of Plk2 (Snk) in mouse development and cell proliferation.

PubMed ID: 12972611

DOI: 10.1128/mcb.23.19.6936-6943.2003

PubMed ID: 19004816

Title: Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system.

PubMed ID: 19004816

DOI: 10.1074/jbc.c800206200

PubMed ID: 21382555

Title: Requirement for Plk2 in orchestrated ras and rap signaling, homeostatic structural plasticity, and memory.

PubMed ID: 21382555

DOI: 10.1016/j.neuron.2011.02.004

Sequence Information:

Length: 682
Mass: 77812
Checksum: 586DEABFD7208A9D
Sequence:

MELLRTITYQ PAAGTKMCEQ ALGKACGGDS KKKRPQQPSE DGQPQAQVTP AAPHHHHHHS 
HSGPEISRII VDPTTGKRYC RGKVLGKGGF AKCYEMTDLT NNKVYAAKII PHSRVAKPHQ 
REKIDKEIEL HRLLHHKHVV QFYHYFEDKE NIYILLEYCS RRSMAHILKA RKVLTEPEVR 
YYLRQIVSGL KYLHEQEILH RDLKLGNFFI NEAMELKVGD FGLAARLEPL EHRRRTICGT 
PNYLSPEVLN KQGHGCESDI WALGCVMYTM LLGRPPFETT NLKETYRCIR EARYTMPSSL 
LAPAKHLIAS MLSKNPEDRP SLDDIIRHDF FLQGFTPDRL SSSCCHTVPD FHLSSPAKNF 
FKKAAAALFG GKKDKARYND THNKVSKEDE DIYKLRHDLK KVSITQQPSK HRADEEPQPP 
PTTVARSGTS AVENKQQIGD AIRMIVRGTL GSCSSSSECL EDSTMGSVAD TVARVLRGCL 
ENMPEADCIP KEQLSTSFQW VTKWVDYSNK YGFGYQLSDH TVGVLFNNGA HMSLLPDKKT 
VHYYAELGQC SVFPATDAPE QFISQVTVLK YFSHYMEENL MDGGDLPSVT DIRRPRLYLL 
QWLKSDKALM MLFNDGTFQV NFYHDHTKII ICNQSEEYLL TYINEDRIST TFRLTTLLMS 
GCSLELKNRM EYALNMLLQR CN

Genular Protein ID: 2698642771

Symbol: Q3TV29_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3TV29

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 121
Mass: 14376
Checksum: 7BFBFCE237E77A6F
Sequence:

FISQVTVLKY FSHYMEENLM DGGDLPSVTD IRRPRLYLLQ WLKSDKALMM LFNDGTFQVN 
FYHDHTKIII CNQSEEYLLT YINEDRISTT FRLTTLLMSG CSLELKNRME YALNMLLQRC 
N

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Plk2

Associated with

Other Information

Identification of an early-growth-response gene encoding a novel putative protein kinase. PubMed ID: 1508211

The serum-inducible protein kinase Snk is a G1 phase polo-like kinase that is inhibited by the calcium- and integrin-binding protein CIB. PubMed ID: 12651910

Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells. PubMed ID: 12897130

Role of Plk2 (Snk) in mouse development and cell proliferation. PubMed ID: 12972611

Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system. PubMed ID: 19004816

Requirement for Plk2 in orchestrated ras and rap signaling, homeostatic structural plasticity, and memory. PubMed ID: 21382555

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073