Genular: Defining Cellular Identity and Function

Details for: Soat1

Gene ID: 20652

Symbol: Soat1

Ensembl ID: ENSMUSG00000026600

Description: sterol O-acyltransferase 1

Associated with

Ldl clearance
(R-MMU-8964038)
Plasma lipoprotein assembly, remodeling, and clearance
(R-MMU-174824)
Plasma lipoprotein clearance
(R-MMU-8964043)
Transport of small molecules
(R-MMU-382551)
Acyltransferase activity
(GO:0016746)
Cholesterol binding
(GO:0015485)
Cholesterol efflux
(GO:0033344)
Cholesterol homeostasis
(GO:0042632)
Cholesterol metabolic process
(GO:0008203)
Cholesterol o-acyltransferase activity
(GO:0034736)
Cholesterol storage
(GO:0010878)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Fatty-acyl-coa binding
(GO:0000062)
Identical protein binding
(GO:0042802)
Lipid metabolic process
(GO:0006629)
Macrophage derived foam cell differentiation
(GO:0010742)
Membrane
(GO:0016020)
O-acyltransferase activity
(GO:0008374)
Positive regulation of amyloid precursor protein biosynthetic process
(GO:0042986)
Steroid metabolic process
(GO:0008202)
Sterol o-acyltransferase activity
(GO:0004772)
Transferase activity
(GO:0016740)
Very-low-density lipoprotein particle assembly
(GO:0034379)

Other Information

Proteins

Acyl-coenzyme A:cholesterol acyltransferase 1

Genular Protein ID: 2633554970

Symbol: SOAT1_MOUSE

Name: Acyl-coenzyme A:cholesterol acyltransferase 1

UniProtKB Accession Codes:

Q61263 Q5XK32 Q64180

Database IDs:

Citations:

PubMed ID: 7592824

Title: Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice. Molecular cloning of mouse ACAT cDNA, chromosomal localization, and regulation of ACAT in vivo and in vitro.

PubMed ID: 7592824

DOI: 10.1074/jbc.270.44.26192

PubMed ID: 8579615

Title: Cloning and expression in Xenopus oocytes of a mouse homologue of the human acylcoenzyme A: cholesterol acyltransferase and its potential role in metabolism of oxidized LDL.

PubMed ID: 8579615

DOI: 10.1006/bbrc.1996.0163

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11071899

Title: ACAT1 and ACAT2 membrane topology segregates a serine residue essential for activity to opposite sides of the endoplasmic reticulum membrane.

PubMed ID: 11071899

DOI: 10.1091/mbc.11.11.3675

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 540
Mass: 63799
Checksum: F2A6C91774762E23
Sequence:

MSLRNRLSKS GENPEQDEAQ KNFMDTYRNG HITMKQLIAK KRLLAAEAEE LKPLFMKEVG 
CHFDDFVTNL IEKSASLDNG GCALTTFSIL EEMKKNHRAK DLRAPPEQGK IFISRQSLLD 
ELFEVDHIRT IYHMFIALLI LFVLSTIVVD YIDEGRLVLE FNLLAYAFGK FPTVIWTWWA 
MFLSTLSIPY FLFQRWAHGY SKSSHPLIYS LVHGLLFLVF QLGVLGFVPT YVVLAYTLPP 
ASRFILILEQ IRLIMKAHSF VRENIPRVLN AAKEKSSKDP LPTVNQYLYF LFAPTLIYRD 
NYPRTPTVRW GYVAMQFLQV FGCLFYVYYI FERLCAPLFR NIKQEPFSAR VLVLCVFNSI 
LPGVLILFLS FFAFLHCWLN AFAEMLRFGD RMFYKDWWNS TSYSNYYRTW NVVVHDWLYY 
YVYKDLLWFF SKRFKSAAML AVFALSAVVH EYALAICLSY FYPVLFVLFM FFGMAFNFIV 
NDSRKRPIWN IMVWASLFLG YGLILCFYSQ EWYARQHCPL KNPTFLDYVR PRTWTCRYVF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Soat1

Associated with

Other Information

Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice. Molecular cloning of mouse ACAT cDNA, chromosomal localization, and regulation of ACAT in vivo and in vitro. PubMed ID: 7592824

Cloning and expression in Xenopus oocytes of a mouse homologue of the human acylcoenzyme A: cholesterol acyltransferase and its potential role in metabolism of oxidized LDL. PubMed ID: 8579615

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

ACAT1 and ACAT2 membrane topology segregates a serine residue essential for activity to opposite sides of the endoplasmic reticulum membrane. PubMed ID: 11071899