Genular: Defining Cellular Identity and Function

Details for: Sod2

Gene ID: 20656

Symbol: Sod2

Ensembl ID: ENSMUSG00000006818

Description: superoxide dismutase 2, mitochondrial

Associated with

Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to chemical stress
(R-MMU-9711123)
Detoxification of reactive oxygen species
(R-MMU-3299685)
Mitochondrial biogenesis
(R-MMU-1592230)
Organelle biogenesis and maintenance
(R-MMU-1852241)
Transcriptional activation of mitochondrial biogenesis
(R-MMU-2151201)
Acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure
(GO:0003069)
Apoptotic mitochondrial changes
(GO:0008637)
Cellular response to oxidative stress
(GO:0034599)
Detection of oxygen
(GO:0003032)
Dna binding
(GO:0003677)
Enzyme binding
(GO:0019899)
Erythrophore differentiation
(GO:0048773)
Glutathione metabolic process
(GO:0006749)
Heart development
(GO:0007507)
Hemopoiesis
(GO:0030097)
Hydrogen peroxide biosynthetic process
(GO:0050665)
Hydrogen peroxide metabolic process
(GO:0042743)
Identical protein binding
(GO:0042802)
Intracellular oxygen homeostasis
(GO:0032364)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Intrinsic apoptotic signaling pathway in response to oxidative stress
(GO:0008631)
Liver development
(GO:0001889)
Locomotory behavior
(GO:0007626)
Manganese ion binding
(GO:0030145)
Metal ion binding
(GO:0046872)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial matrix
(GO:0005759)
Mitochondrial nucleoid
(GO:0042645)
Mitochondrion
(GO:0005739)
Mitochondrion organization
(GO:0007005)
Multicellular organismal-level iron ion homeostasis
(GO:0060586)
Myelin sheath
(GO:0043209)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of fat cell differentiation
(GO:0045599)
Negative regulation of fibroblast proliferation
(GO:0048147)
Negative regulation of membrane hyperpolarization
(GO:1902631)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
(GO:1902176)
Negative regulation of vascular associated smooth muscle cell proliferation
(GO:1904706)
Neuron development
(GO:0048666)
Oxidoreductase activity
(GO:0016491)
Oxygen binding
(GO:0019825)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of hydrogen peroxide biosynthetic process
(GO:0010729)
Positive regulation of nitric oxide biosynthetic process
(GO:0045429)
Positive regulation of vascular associated smooth muscle cell apoptotic process
(GO:1905461)
Positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
(GO:1905932)
Post-embryonic development
(GO:0009791)
Protein binding
(GO:0005515)
Protein homotetramerization
(GO:0051289)
Regulation of blood pressure
(GO:0008217)
Regulation of catalytic activity
(GO:0050790)
Regulation of mitochondrial membrane potential
(GO:0051881)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Release of cytochrome c from mitochondria
(GO:0001836)
Removal of superoxide radicals
(GO:0019430)
Respiratory electron transport chain
(GO:0022904)
Response to activity
(GO:0014823)
Response to axon injury
(GO:0048678)
Response to gamma radiation
(GO:0010332)
Response to hydrogen peroxide
(GO:0042542)
Response to hyperoxia
(GO:0055093)
Response to nutrient levels
(GO:0031667)
Response to oxidative stress
(GO:0006979)
Response to reactive oxygen species
(GO:0000302)
Response to superoxide
(GO:0000303)
Response to xenobiotic stimulus
(GO:0009410)
Sensory perception of sound
(GO:0007605)
Superoxide anion generation
(GO:0042554)
Superoxide dismutase activity
(GO:0004784)
Superoxide metabolic process
(GO:0006801)
Vasodilation
(GO:0042311)

Other Information

Proteins

Superoxide dismutase [Mn], mitochondrial

Genular Protein ID: 2508138232

Symbol: SODM_MOUSE

Name: Superoxide dismutase [Mn], mitochondrial

UniProtKB Accession Codes:

P09671 Q64670 Q8VEM5

Database IDs:

Citations:

PubMed ID: 3797253

Title: Sequence of a cDNA coding for mouse manganese superoxide dismutase.

PubMed ID: 3797253

DOI: 10.1093/nar/14.23.9539

PubMed ID: 8406027

Title: Sequence of manganese superoxide dismutase-encoding cDNAs from multiple mouse organs.

PubMed ID: 8406027

DOI: 10.1016/0378-1119(93)90311-p

PubMed ID: 7875582

Title: Cloning and characterization of the murine manganous superoxide dismutase-encoding gene.

PubMed ID: 7875582

DOI: 10.1016/0378-1119(94)00666-g

PubMed ID: 7613035

Title: Structure and DNA sequence of the mouse MnSOD gene.

PubMed ID: 7613035

DOI: 10.1007/bf00352417

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21172655

Title: Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.

PubMed ID: 21172655

DOI: 10.1016/j.molcel.2010.12.013

PubMed ID: 20668652

Title: KRIT1 regulates the homeostasis of intracellular reactive oxygen species.

PubMed ID: 20668652

DOI: 10.1371/journal.pone.0011786

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 23576753

Title: Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.

PubMed ID: 23576753

DOI: 10.1073/pnas.1302961110

Sequence Information:

Length: 222
Mass: 24603
Checksum: 9AE804C55A8357D9
Sequence:

MLCRAACSTG RRLGPVAGAA GSRHKHSLPD LPYDYGALEP HINAQIMQLH HSKHHAAYVN 
NLNATEEKYH EALAKGDVTT QVALQPALKF NGGGHINHTI FWTNLSPKGG GEPKGELLEA 
IKRDFGSFEK FKEKLTAVSV GVQGSGWGWL GFNKEQGRLQ IAACSNQDPL QGTTGLIPLL 
GIDVWEHAYY LQYKNVRPDY LKAIWNVINW ENVTERYTAC KK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Sod2

Associated with

Other Information

Sequence of a cDNA coding for mouse manganese superoxide dismutase. PubMed ID: 3797253

Sequence of manganese superoxide dismutase-encoding cDNAs from multiple mouse organs. PubMed ID: 8406027

Cloning and characterization of the murine manganous superoxide dismutase-encoding gene. PubMed ID: 7875582

Structure and DNA sequence of the mouse MnSOD gene. PubMed ID: 7613035

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. PubMed ID: 21172655

KRIT1 regulates the homeostasis of intracellular reactive oxygen species. PubMed ID: 20668652

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. PubMed ID: 23576753