Genular: Defining Cellular Identity and Function

Details for: Sorl1

Gene ID: 20660

Symbol: Sorl1

Ensembl ID: ENSMUSG00000049313

Description: sortilin-related receptor, LDLR class A repeats-containing

Associated with

Adaptive thermogenesis
(GO:1990845)
Amyloid-beta binding
(GO:0001540)
Aspartic-type endopeptidase inhibitor activity
(GO:0019828)
Cell migration
(GO:0016477)
Cell surface
(GO:0009986)
Cytoplasmic vesicle
(GO:0031410)
Diet induced thermogenesis
(GO:0002024)
Early endosome
(GO:0005769)
Endocytosis
(GO:0006897)
Endoplasmic reticulum
(GO:0005783)
Endosome
(GO:0005768)
Endosome to plasma membrane protein transport
(GO:0099638)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Golgi apparatus
(GO:0005794)
Golgi cisterna
(GO:0031985)
Insulin receptor recycling
(GO:0038020)
Low-density lipoprotein particle binding
(GO:0030169)
Membrane
(GO:0016020)
Multicellular organism development
(GO:0007275)
Multivesicular body
(GO:0005771)
Negative regulation of amyloid-beta formation
(GO:1902430)
Negative regulation of amyloid precursor protein catabolic process
(GO:1902992)
Negative regulation of bmp signaling pathway
(GO:0030514)
Negative regulation of neurofibrillary tangle assembly
(GO:1902997)
Negative regulation of neurogenesis
(GO:0050768)
Negative regulation of protein-containing complex assembly
(GO:0031333)
Negative regulation of triglyceride catabolic process
(GO:0010897)
Neuronal cell body
(GO:0043025)
Neuropeptide binding
(GO:0042923)
Neuropeptide signaling pathway
(GO:0007218)
Nuclear envelope lumen
(GO:0005641)
Perinuclear region of cytoplasm
(GO:0048471)
Perinucleolar compartment
(GO:0097356)
Plasma membrane
(GO:0005886)
Positive regulation of adipose tissue development
(GO:1904179)
Positive regulation of early endosome to recycling endosome transport
(GO:1902955)
Positive regulation of endocytic recycling
(GO:2001137)
Positive regulation of er to golgi vesicle-mediated transport
(GO:1902953)
Positive regulation of glial cell-derived neurotrophic factor production
(GO:1900168)
Positive regulation of insulin receptor signaling pathway
(GO:0046628)
Positive regulation of protein catabolic process
(GO:0045732)
Positive regulation of protein exit from endoplasmic reticulum
(GO:0070863)
Positive regulation of protein localization to early endosome
(GO:1902966)
Post-golgi vesicle-mediated transport
(GO:0006892)
Protein binding
(GO:0005515)
Protein localization to golgi apparatus
(GO:0034067)
Protein maturation
(GO:0051604)
Protein retention in golgi apparatus
(GO:0045053)
Protein targeting
(GO:0006605)
Protein targeting to lysosome
(GO:0006622)
Receptor-mediated endocytosis
(GO:0006898)
Recycling endosome
(GO:0055037)
Regulation of smooth muscle cell migration
(GO:0014910)
Small gtpase binding
(GO:0031267)
Trans-golgi network
(GO:0005802)
Transmembrane signaling receptor activity
(GO:0004888)

Other Information

Proteins

Sortilin-related receptor

Genular Protein ID: 665881730

Symbol: SORL_MOUSE

Name: Sortilin-related receptor

UniProtKB Accession Codes:

O88307 O54711 O70581 Q3UHM3

Database IDs:

Citations:

PubMed ID: 9726247

Title: Developmental regulation of LR11 expression in murine brain.

PubMed ID: 9726247

DOI: 10.1089/dna.1998.17.647

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 9510025

Title: Unique expression pattern of a novel mosaic receptor in the developing cerebral cortex.

PubMed ID: 9510025

DOI: 10.1016/s0925-4773(97)00177-9

PubMed ID: 11082041

Title: Ectodomain shedding, translocation and synthesis of SorLA are stimulated by its ligand head activator.

PubMed ID: 11082041

DOI: 10.1242/jcs.113.24.4475

PubMed ID: 14764453

Title: LR11, an LDL receptor gene family member, is a novel regulator of smooth muscle cell migration.

PubMed ID: 14764453

DOI: 10.1161/01.res.0000120862.79154.0f

PubMed ID: 16174740

Title: Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.

PubMed ID: 16174740

DOI: 10.1073/pnas.0503689102

PubMed ID: 16407538

Title: Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.

PubMed ID: 16407538

DOI: 10.1523/jneurosci.3882-05.2006

PubMed ID: 17332490

Title: A secreted soluble form of LR11, specifically expressed in intimal smooth muscle cells, accelerates formation of lipid-laden macrophages.

PubMed ID: 17332490

DOI: 10.1161/atvbaha.106.137091

PubMed ID: 20007471

Title: Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression.

PubMed ID: 20007471

DOI: 10.1523/jneurosci.3960-09.2009

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20385770

Title: SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2.

PubMed ID: 20385770

DOI: 10.1128/mcb.01560-09

PubMed ID: 21994944

Title: Sorting protein-related receptor SorLA controls regulated secretion of glial cell line-derived neurotrophic factor.

PubMed ID: 21994944

DOI: 10.1074/jbc.m111.246413

PubMed ID: 21385844

Title: SorLA regulates the activity of lipoprotein lipase by intracellular trafficking.

PubMed ID: 21385844

DOI: 10.1242/jcs.072538

PubMed ID: 23333276

Title: SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRalpha1 and RET.

PubMed ID: 23333276

DOI: 10.1016/j.celrep.2012.12.011

PubMed ID: 23486467

Title: The soluble form of LR11 protein is a regulator of hypoxia-induced, urokinase-type plasminogen activator receptor (uPAR)-mediated adhesion of immature hematological cells.

PubMed ID: 23486467

DOI: 10.1074/jbc.m112.442491

PubMed ID: 23977241

Title: SORLA-mediated trafficking of TrkB enhances the response of neurons to BDNF.

PubMed ID: 23977241

DOI: 10.1371/journal.pone.0072164

PubMed ID: 26584636

Title: Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans.

PubMed ID: 26584636

DOI: 10.1038/ncomms9951

PubMed ID: 25967121

Title: Calcineurin and sorting-related receptor with A-type repeats interact to regulate the renal Na(+)-K(+)-2Cl(-) cotransporter.

PubMed ID: 25967121

DOI: 10.1681/asn.2014070728

PubMed ID: 27322061

Title: SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.

PubMed ID: 27322061

DOI: 10.1172/jci84708

PubMed ID: 26858303

Title: Cytokine-like factor 1, an essential facilitator of cardiotrophin-like cytokine:ciliary neurotrophic factor receptor alpha signaling and sorLA-mediated turnover.

PubMed ID: 26858303

DOI: 10.1128/mcb.00917-15

PubMed ID: 28265003

Title: SorLA in Interleukin-6 Signaling and Turnover.

PubMed ID: 28265003

DOI: 10.1128/mcb.00641-16

PubMed ID: 30679749

Title: HSPA12A targets the cytoplasmic domain and affects the trafficking of the Amyloid Precursor Protein receptor SorLA.

PubMed ID: 30679749

DOI: 10.1038/s41598-018-37336-6

Sequence Information:

Length: 2215
Mass: 247086
Checksum: 5D7F53806EFE2CB0
Sequence:

MATRSSRRES RLPFLFALVA LLPRGALGGG WTQRLHGGPA PLPQDRGFFV VQGDPRDLRL 
GTHGDAPGAS PAARKPLRTR RSAALQPQPI QVYGQVSLND SHNQMVVHWA GEKSNVIVAL 
ARDSLALARP KSSDVYVSYD YGKSFSKISE KLNFGVGNNS EAVISQFYHS PADNKRYIFV 
DAYAQYLWIT FDFCSTIHGF SIPFRAADLL LHSKASNLLL GFDRSHPNKQ LWKSDDFGQT 
WIMIQEHVKS FSWGIDPYDQ PNAIYIERHE PFGFSTVLRS TDFFQSRENQ EVILEEVRDF 
QLRDKYMFAT KVVHLPGSQQ QSSVQLWVSF GRKPMRAAQF VTKHPINEYY IADAAEDQVF 
VCVSHSNNST NLYISEAEGL KFSLSLENVL YYSPGGAGSD TLVRYFANEP FADFHRVEGL 
QGVYIATLIN GSMNEENMRS VITFDKGGTW EFLQAPAFTG YGEKINCELS QGCSLHLAQR 
LSQLLNLQLR RMPILSKESA PGLIIATGSV GKNLASKTNV YISSSAGARW REALPGPHYY 
TWGDHGGIIM AIAQGMETNE LKYSTNEGET WKTFVFSEKP VFVYGLLTEP GEKSTVFTIF 
GSNKESVHSW LILQVNATDA LGVPCTENDY KLWSPSDERG NECLLGHKTV FKRRTPHATC 
FNGEDFDRPV VVSNCSCTRE DYECDFGFKM SEDLSLEVCV PDPEFSGKPY SPPVPCPVGS 
SYRRTRGYRK ISGDTCSGGD VEARLEGELV PCPLAEENEF ILYAMRKSIY RYDLASGATE 
QLPLSGLRAA VALDFDYERN CLYWSDLALD TIQRLCLNGS TGQEVIINSG LETVEALAFE 
PLSQLLYWVD AGFKKIEVAN PDGDFRLTIV NSSVLDRPRA LVLVPQEGVM FWTDWGDLKP 
GIYRSYMDGS AAYRLVSEDV KWPNGISVDS QWIYWTDAYL DCIERITFSG QQRSVILDSL 
PHPYAIAVFK NEIYWDDWSQ LSIFRASKHS RSQVEILASQ LTGLMDMKVF YKGKNAGSNA 
CVPQPCSLLC LPKANNSKSC RCPEGVASSV LPSGDLMCDC PQGYQRKNNT CVKEENTCLR 
NQYRCSNGNC INSIWWCDFD NDCGDMSDER NCPTTVCDAD TQFRCQESGT CIPLSYKCDL 
EDDCGDNSDE SHCEMHQCRS DEFNCSSGMC IRSSWVCDGD NDCRDWSDEA NCTAIYHTCE 
ASNFQCHNGH CIPQRWACDG DADCQDGSDE DPVSCEKKCN GFHCPNGTCI PSSKHCDGLR 
DCPDGSDEQH CEPFCTRFMD FVCKNRQQCL FHSMVCDGIV QCRDGSDEDA AFAGCSQDPE 
FHKECDEFGF QCQNGVCISL IWKCDGMDDC GDYSDEANCE NPTEAPNCSR YFQFHCENGH 
CIPNRWKCDR ENDCGDWSDE KDCGDSHVLP SPTPGPSTCL PNYFHCSSGA CVMGTWVCDG 
YRDCADGSDE EACPSLANST AASTPTQFGQ CDRFEFECHQ PKKCIPNWKR CDGHQDCQDG 
QDEANCPTHS TLTCTSREFK CEDGEACIVL SERCDGFLDC SDESDEKACS DELTVYKVQN 
LQWTADFSGD VTLTWMRPKK MPSASCVYNV YYRVVGESIW KTLETHSNKT STVLKVLKPD 
TTYQVKVQVH CLNKVHNTND FVTLRTPEGL PDAPRNLQLS LNSEEEGVIL GHWAPPVHTH 
GLIREYIVEY SRSGSKMWAS QRAASNSTEI KNLLLNALYT VRVAAVTSRG IGNWSDSKSI 
TTIKGKVIQA PNIHIDSYDE NSLSFTLTMD GDIKVNGYVV NLFWSFDAHK QEKKTLSFRG 
GSALSHRVSN LTAHTSYEIS AWAKTDLGDS PLAFEHILTR GSSPPAPSLK AKAINQTAVE 
CIWTGPKNVV YGIFYATSFL DLYRNPKSVT TSLHNKTVIV SKDEQYLFLV RVLIPYQGPS 
SDYVVVKMIP DSRLPPRHLH AVHIGKTSAL IKWESPYDSP DQDLFYAIAV KDLIRKTDRS 
YKVRSRNSTV EYSLSKLEPG GKYHIIVQLG NMSKDSSIKI TTVSLSAPDA LKIITENDHV 
LLFWKSLALK EKQFNETRGY EIHMSDSAVN LTAYLGNTTD NFFKVSNLKM GHNYTFTVQA 
RCLFGSQICG EPAVLLYDEL SSGADAAVIQ AARSTDVAAV VVPILFLILL SLGVGFAILY 
TKHRRLQSSF SAFANSHYSS RLGSAIFSSG DDLGEDDEDA PMITGFSDDV PMVIA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Sorl1

Associated with

Other Information

Developmental regulation of LR11 expression in murine brain. PubMed ID: 9726247

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Unique expression pattern of a novel mosaic receptor in the developing cerebral cortex. PubMed ID: 9510025

Ectodomain shedding, translocation and synthesis of SorLA are stimulated by its ligand head activator. PubMed ID: 11082041

LR11, an LDL receptor gene family member, is a novel regulator of smooth muscle cell migration. PubMed ID: 14764453

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. PubMed ID: 16174740

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme. PubMed ID: 16407538

A secreted soluble form of LR11, specifically expressed in intimal smooth muscle cells, accelerates formation of lipid-laden macrophages. PubMed ID: 17332490

Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression. PubMed ID: 20007471

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2. PubMed ID: 20385770

Sorting protein-related receptor SorLA controls regulated secretion of glial cell line-derived neurotrophic factor. PubMed ID: 21994944

SorLA regulates the activity of lipoprotein lipase by intracellular trafficking. PubMed ID: 21385844

SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRalpha1 and RET. PubMed ID: 23333276

The soluble form of LR11 protein is a regulator of hypoxia-induced, urokinase-type plasminogen activator receptor (uPAR)-mediated adhesion of immature hematological cells. PubMed ID: 23486467

SORLA-mediated trafficking of TrkB enhances the response of neurons to BDNF. PubMed ID: 23977241

Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. PubMed ID: 26584636

Calcineurin and sorting-related receptor with A-type repeats interact to regulate the renal Na(+)-K(+)-2Cl(-) cotransporter. PubMed ID: 25967121

SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity. PubMed ID: 27322061

Cytokine-like factor 1, an essential facilitator of cardiotrophin-like cytokine:ciliary neurotrophic factor receptor alpha signaling and sorLA-mediated turnover. PubMed ID: 26858303

SorLA in Interleukin-6 Signaling and Turnover. PubMed ID: 28265003

HSPA12A targets the cytoplasmic domain and affects the trafficking of the Amyloid Precursor Protein receptor SorLA. PubMed ID: 30679749