Genular: Defining Cellular Identity and Function

Details for: Sort1

Gene ID: 20661

Symbol: Sort1

Ensembl ID: ENSMUSG00000068747

Description: sortilin 1

Associated with

Golgi associated vesicle biogenesis
(R-MMU-432722)
Membrane trafficking
(R-MMU-199991)
Trans-golgi network vesicle budding
(R-MMU-199992)
Vesicle-mediated transport
(R-MMU-5653656)
Cell differentiation
(GO:0030154)
Cell surface
(GO:0009986)
Cerebellar climbing fiber to purkinje cell synapse
(GO:0150053)
Clathrin-coated pit
(GO:0005905)
Clathrin-coated vesicle
(GO:0030136)
Cytoplasmic vesicle
(GO:0031410)
Cytoplasmic vesicle membrane
(GO:0030659)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Early endosome
(GO:0005769)
Endocytosis
(GO:0006897)
Endoplasmic reticulum
(GO:0005783)
Endosome
(GO:0005768)
Endosome membrane
(GO:0010008)
Endosome to lysosome transport
(GO:0008333)
Endosome transport via multivesicular body sorting pathway
(GO:0032509)
Enzyme binding
(GO:0019899)
Extrinsic apoptotic signaling pathway via death domain receptors
(GO:0008625)
Glucose import
(GO:0046323)
Golgi apparatus
(GO:0005794)
Golgi to endosome transport
(GO:0006895)
Golgi to lysosome transport
(GO:0090160)
G protein-coupled receptor signaling pathway
(GO:0007186)
Lysosome
(GO:0005764)
Maintenance of synapse structure
(GO:0099558)
Membrane
(GO:0016020)
Multicellular organism development
(GO:0007275)
Myotube differentiation
(GO:0014902)
Negative regulation of fat cell differentiation
(GO:0045599)
Negative regulation of lipoprotein lipase activity
(GO:0051005)
Nerve growth factor binding
(GO:0048406)
Nerve growth factor receptor activity
(GO:0010465)
Neuronal cell body
(GO:0043025)
Neuropeptide signaling pathway
(GO:0007218)
Neurotensin receptor activity, non-g protein-coupled
(GO:0030379)
Neurotrophin trk receptor signaling pathway
(GO:0048011)
Nucleus
(GO:0005634)
Ossification
(GO:0001503)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Plasma membrane to endosome transport
(GO:0048227)
Positive regulation of epithelial cell apoptotic process
(GO:1904037)
Protein binding
(GO:0005515)
Protein targeting to lysosome
(GO:0006622)
Regulation of gene expression
(GO:0010468)
Response to insulin
(GO:0032868)
Retromer complex binding
(GO:1905394)
Trans-golgi network transport vesicle
(GO:0030140)
Vesicle organization
(GO:0016050)

Other Information

Proteins

Neurotensin receptor 3

Genular Protein ID: 980514844

Symbol: SORT_MOUSE

Name: Neurotensin receptor 3

UniProtKB Accession Codes:

Q6PHU5 A2AEE8 Q3UHE2 Q8K043 Q9QXW6

Database IDs:

Citations:

PubMed ID: 11322955

Title: Pharmacological properties of the mouse neurotensin receptor 3. Maintenance of cell surface receptor during internalization of neurotensin.

PubMed ID: 11322955

DOI: 10.1016/s0014-5793(01)02367-5

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9452485

Title: Sortilin is the major 110-kDa protein in GLUT4 vesicles from adipocytes.

PubMed ID: 9452485

DOI: 10.1074/jbc.273.6.3582

PubMed ID: 10064893

Title: Expression of the 100-kDa neurotensin receptor sortilin during mouse embryonal development.

PubMed ID: 10064893

DOI: 10.1016/s0169-328x(99)00022-4

PubMed ID: 10085125

Title: Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase.

PubMed ID: 10085125

DOI: 10.1074/jbc.274.13.8832

PubMed ID: 10594043

Title: Characterization of insulin-responsive GLUT4 storage vesicles isolated from 3T3-L1 adipocytes.

PubMed ID: 10594043

DOI: 10.1128/mcb.20.1.416-427.2000

PubMed ID: 15236332

Title: Study of the mouse sortilin gene: effects of its transient silencing by RNA interference in TM4 Sertoli cells.

PubMed ID: 15236332

DOI: 10.1002/mrd.20097

PubMed ID: 15236333

Title: The trafficking of prosaposin (SGP-1) and GM2AP to the lysosomes of TM4 Sertoli cells is mediated by sortilin and monomeric adaptor proteins.

PubMed ID: 15236333

DOI: 10.1002/mrd.20096

PubMed ID: 15372498

Title: Neurotensin receptor-3/sortilin mediates neurotensin-induced cytokine/chemokine expression in a murine microglial cell line.

PubMed ID: 15372498

DOI: 10.1002/jnr.20231

PubMed ID: 15992544

Title: Sortilin is essential and sufficient for the formation of Glut4 storage vesicles in 3T3-L1 adipocytes.

PubMed ID: 15992544

DOI: 10.1016/j.devcel.2005.04.004

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19407813

Title: NRH2 is a trafficking switch to regulate sortilin localization and permit proneurotrophin-induced cell death.

PubMed ID: 19407813

DOI: 10.1038/emboj.2009.118

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21102451

Title: Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.

PubMed ID: 21102451

DOI: 10.1038/nn.2689

Sequence Information:

Length: 825
Mass: 91200
Checksum: 9A7A73C6FE1C8201
Sequence:

MERPRGAADG LLRWPLGLLL LLQLLPPAAV GQDRLDAPPP PAPPLLRWAG PVGVSWGLRA 
AAPGGPVPRA GRWRRGAPAE DQDCGRLPDF IAKLTNNTHQ HVFDDLSGSV SLSWVGDSTG 
VILVLTTFQV PLVIVSFGQS KLYRSEDYGK NFKDITNLIN NTFIRTEFGM AIGPENSGKV 
ILTAEVSGGS RGGRVFRSSD FAKNFVQTDL PFHPLTQMMY SPQNSDYLLA LSTENGLWVS 
KNFGEKWEEI HKAVCLAKWG PNNIIFFTTH VNGSCKADLG ALELWRTSDL GKTFKTIGVK 
IYSFGLGGRF LFASVMADKD TTRRIHVSTD QGDTWSMAQL PSVGQEQFYS ILAANEDMVF 
MHVDEPGDTG FGTIFTSDDR GIVYSKSLDR HLYTTTGGET DFTNVTSLRG VYITSTLSED 
NSIQSMITFD QGGRWEHLRK PENSKCDATA KNKNECSLHI HASYSISQKL NVPMAPLSEP 
NAVGIVIAHG SVGDAISVMV PDVYISDDGG YSWAKMLEGP HYYTILDSGG IIVAIEHSNR 
PINVIKFSTD EGQCWQSYVF TQEPIYFTGL ASEPGARSMN ISIWGFTESF ITRQWVSYTV 
DFKDILERNC EEDDYTTWLA HSTDPGDYKD GCILGYKEQF LRLRKSSVCQ NGRDYVVAKQ 
PSVCPCSLED FLCDFGYFRP ENASECVEQP ELKGHELEFC LYGKEEHLTT NGYRKIPGDK 
CQGGMNPARE VKDLKKKCTS NFLNPTKQNS KSNSVPIILA IVGLMLVTVV AGVLIVKKYV 
CGGRFLVHRY SVLQQHAEAD GVEALDSTSH AKSGYHDDSD EDLLE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Sort1

Associated with

Other Information

Pharmacological properties of the mouse neurotensin receptor 3. Maintenance of cell surface receptor during internalization of neurotensin. PubMed ID: 11322955

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Sortilin is the major 110-kDa protein in GLUT4 vesicles from adipocytes. PubMed ID: 9452485

Expression of the 100-kDa neurotensin receptor sortilin during mouse embryonal development. PubMed ID: 10064893

Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. PubMed ID: 10085125

Characterization of insulin-responsive GLUT4 storage vesicles isolated from 3T3-L1 adipocytes. PubMed ID: 10594043

Study of the mouse sortilin gene: effects of its transient silencing by RNA interference in TM4 Sertoli cells. PubMed ID: 15236332

The trafficking of prosaposin (SGP-1) and GM2AP to the lysosomes of TM4 Sertoli cells is mediated by sortilin and monomeric adaptor proteins. PubMed ID: 15236333

Neurotensin receptor-3/sortilin mediates neurotensin-induced cytokine/chemokine expression in a murine microglial cell line. PubMed ID: 15372498

Sortilin is essential and sufficient for the formation of Glut4 storage vesicles in 3T3-L1 adipocytes. PubMed ID: 15992544

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

NRH2 is a trafficking switch to regulate sortilin localization and permit proneurotrophin-induced cell death. PubMed ID: 19407813

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling. PubMed ID: 21102451