Genular: Defining Cellular Identity and Function

Details for: Sos1

Gene ID: 20662

Symbol: Sos1

Ensembl ID: ENSMUSG00000024241

Description: SOS Ras/Rac guanine nucleotide exchange factor 1

Associated with

Activated ntrk2 signals through frs2 and frs3
(R-MMU-9028731)
Adaptive immune system
(R-MMU-1280218)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-MMU-983695)
Axon guidance
(R-MMU-422475)
Cell death signalling via nrage, nrif and nade
(R-MMU-204998)
Cell surface interactions at the vascular wall
(R-MMU-202733)
Cytokine signaling in immune system
(R-MMU-1280215)
Dap12 interactions
(R-MMU-2172127)
Dap12 signaling
(R-MMU-2424491)
Death receptor signaling
(R-MMU-73887)
Developmental biology
(R-MMU-1266738)
Downstream signaling of activated fgfr1
(R-MMU-5654687)
Downstream signaling of activated fgfr2
(R-MMU-5654696)
Downstream signaling of activated fgfr3
(R-MMU-5654708)
Downstream signaling of activated fgfr4
(R-MMU-5654716)
Downstream signal transduction
(R-MMU-186763)
Egfr transactivation by gastrin
(R-MMU-2179392)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated ca+2 mobilization
(R-MMU-2871809)
Fceri mediated mapk activation
(R-MMU-2871796)
Flt3 signaling
(R-MMU-9607240)
Frs-mediated fgfr1 signaling
(R-MMU-5654693)
Frs-mediated fgfr2 signaling
(R-MMU-5654700)
Frs-mediated fgfr3 signaling
(R-MMU-5654706)
Frs-mediated fgfr4 signaling
(R-MMU-5654712)
G alpha (12/13) signalling events
(R-MMU-416482)
G alpha (q) signalling events
(R-MMU-416476)
Gastrin-creb signalling pathway via pkc and mapk
(R-MMU-881907)
Gpcr downstream signalling
(R-MMU-388396)
Grb2 events in egfr signaling
(R-MMU-179812)
Grb2 events in erbb2 signaling
(R-MMU-1963640)
Grb2:sos provides linkage to mapk signaling for integrins
(R-MMU-354194)
Hemostasis
(R-MMU-109582)
Igf1r signaling cascade
(R-MMU-2428924)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Insulin receptor signalling cascade
(R-MMU-74751)
Integrin signaling
(R-MMU-354192)
Interleukin-2 family signaling
(R-MMU-451927)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-MMU-512988)
Interleukin-15 signaling
(R-MMU-8983432)
Interleukin receptor shc signaling
(R-MMU-912526)
Irs-mediated signalling
(R-MMU-112399)
Irs-related events triggered by igf1r
(R-MMU-2428928)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Met activates ras signaling
(R-MMU-8851805)
Ncam signaling for neurite out-growth
(R-MMU-375165)
Nervous system development
(R-MMU-9675108)
Nrage signals death through jnk
(R-MMU-193648)
P75 ntr receptor-mediated signalling
(R-MMU-193704)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet aggregation (plug formation)
(R-MMU-76009)
Rac1 gtpase cycle
(R-MMU-9013149)
Raf/map kinase cascade
(R-MMU-5673001)
Regulation of kit signaling
(R-MMU-1433559)
Ret signaling
(R-MMU-8853659)
Rho gtpase cycle
(R-MMU-9012999)
Role of lat2/ntal/lab on calcium mobilization
(R-MMU-2730905)
Shc-mediated cascade:fgfr1
(R-MMU-5654688)
Shc-mediated cascade:fgfr2
(R-MMU-5654699)
Shc-mediated cascade:fgfr3
(R-MMU-5654704)
Shc-mediated cascade:fgfr4
(R-MMU-5654719)
Shc-related events triggered by igf1r
(R-MMU-2428933)
Shc1 events in egfr signaling
(R-MMU-180336)
Shc1 events in erbb4 signaling
(R-MMU-1250347)
Signal attenuation
(R-MMU-74749)
Signaling by egfr
(R-MMU-177929)
Signaling by erbb2
(R-MMU-1227986)
Signaling by erbb4
(R-MMU-1236394)
Signaling by fgfr
(R-MMU-190236)
Signaling by fgfr1
(R-MMU-5654736)
Signaling by fgfr2
(R-MMU-5654738)
Signaling by fgfr3
(R-MMU-5654741)
Signaling by fgfr4
(R-MMU-5654743)
Signaling by gpcr
(R-MMU-372790)
Signaling by insulin receptor
(R-MMU-74752)
Signaling by interleukins
(R-MMU-449147)
Signaling by met
(R-MMU-6806834)
Signaling by ntrk1 (trka)
(R-MMU-187037)
Signaling by ntrk2 (trkb)
(R-MMU-9006115)
Signaling by ntrks
(R-MMU-166520)
Signaling by pdgf
(R-MMU-186797)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by scf-kit
(R-MMU-1433557)
Signaling by the b cell receptor (bcr)
(R-MMU-983705)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-MMU-2404192)
Signalling to erks
(R-MMU-187687)
Signalling to ras
(R-MMU-167044)
Signal transduction
(R-MMU-162582)
Sos-mediated signalling
(R-MMU-112412)
Tie2 signaling
(R-MMU-210993)
Epidermal growth factor receptor binding
(GO:0005154)
Guanyl-nucleotide exchange factor activity
(GO:0005085)

Other Information

Proteins

Son of sevenless homolog 1
Q3USK4_MOUSE

Genular Protein ID: 1558884100

Symbol: SOS1_MOUSE

Name: Son of sevenless homolog 1

UniProtKB Accession Codes:

Q62245 Q62244

Database IDs:

Citations:

PubMed ID: 1631150

Title: Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras.

PubMed ID: 1631150

DOI: 10.1073/pnas.89.14.6511

PubMed ID: 10499589

Title: EPS8 and E3B1 transduce signals from Ras to Rac.

PubMed ID: 10499589

DOI: 10.1038/45822

PubMed ID: 11524436

Title: An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine.

PubMed ID: 11524436

DOI: 10.1083/jcb.200103146

PubMed ID: 17114649

Title: Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

PubMed ID: 17114649

DOI: 10.1074/mcp.m600046-mcp200

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 9217262

Title: The solution structure of the pleckstrin homology domain of mouse Son-of-sevenless 1 (mSos1).

PubMed ID: 9217262

DOI: 10.1006/jmbi.1997.1041

Sequence Information:

Length: 1319
Mass: 150883
Checksum: 3286088A5BA0A4A6
Sequence:

MQAQQLPYEF FSEENAPKWR GLLVPALKKV QGQVHPTLES NDDALQYVEE LILQLLNMLC 
QAQPRSASDV EERVQKSFPH PIDKWAIADA QSAIEKRKRR NPLSLPAERI HHLLREVLGY 
KIDHQVSVYI VAVLEYISAD ILKLVGNYVR NIRHYEITKQ DIKVAMCADK VLMDMFHQDV 
EDINILSLTD EEPSTSGEQT YYDLVKAFMA EIRQYIRELN LIIKVFREPF VSNSKLFSSN 
DVENIFSRIV DIHELSVKLL GHIEDTVEMT DEGSPHPLVG SCFEDLAEEL AFDPYESYAR 
DILRPGFHGH FLSQLSKPGA ALYLQSIGEG FKEAVQYVLP RLLLAPVYHC LHYFELLKQL 
EEKSEDQEDK ECMKQAITAL LNVQSGMEKI CSKSLAKRRL SESACRFYSQ QMKGKQLAIK 
KMNEIQKNID GWEGKDIGQC CNEFIMEGTL TRVGAKHERH IFLFDGLMIC CKSNHGQPRL 
PGASSAEYRL KEKFFMRKVQ INDKDDTSEY KHAFEIILKD GNSVIFSAKS AEEKNNWMAA 
LISLQYRSTL ERMLDVTVLQ EEKEEQMRLP SAEVYRFAEP DSEENILFEE NVQPKAGIPI 
IKAGTVLKLI ERLTYHMYAD PNFVRTFLTT YRSFCRPQEL LSLLIERFEI PEPEPTEADR 
IAIENGDQPL SAELKRFRKE YIQPVQLRVL NVCRHWVEHH FYDFERDADL LQRMEEFIGT 
VRGKAMKKWV ESITKIIQRK KIARDNGPGH NITFQSSPPT VEWHISRPGH IETFDLLTLH 
PIEIARQLTL LESDLYRAVQ PSELVGSVWT KEDKEINSPN LLKMIRHTTN LTLWFEKCIV 
ETENLEERVA VVSRIIEILQ VFQELNNFNG VLEVVSAMNS SPVYRLDHTF EQIPSRQKKI 
LEEAHELSED HYKKYLAKLR SINPPCVPFF GIYLTNILKT EEGNPEVLRR HGKELINFSK 
RRRVAEITGE IQQYQNQPYC LRVEPDIKRF FENLNPMGNS MEKEFTDYLF NKSLEIEPRH 
PKPLPRFPKK YSYPLKSPGV RPSNPRPGTM RHPTPLQQEP RKISYSRIPE SETESTASAP 
NSPRTPLTPP PASGTSSNTD VCSVFDSDHS ASPFHSRSAS VSSISLSKGT DEVPVPPPVP 
PRRRPESAPA ESSPSKIMSK HLDSPPAIPP RQPTSKAYSP RYSISDRTSI SDPPESPPLL 
PPREPVRTPD VFSSSPLHLQ PPPLGKKSDH GNAFFPNSPS PFTPPPPQTP SPHGTRRHLP 
SPPLTQEMDL HSIAGPPVPP RQSTSQLIPK LPPKTYKREH THPSMHRDGP PLLENAHSS

Genular Protein ID: 305407983

Symbol: Q3USK4_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3USK4

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 1119
Mass: 129228
Checksum: F9439051E0E9200D
Sequence:

MQAQQLPYEF FSEENAPKWR GLLVPALKKV QGQVHPTLES NDDALQYVEE LILQLLNMLC 
QAQPRSASDV EERVQKSFPH PIDKWAIADA QSAIEKRKRR NPLSLPAERI HHLLREVLGY 
KIDHQVSVYI VAVLEYISAD ILKLVGNYVR NIRHYEITKQ DIKVAMCADK VLMDMFHQDV 
EDINILSLTD EEPSTSGEQT YYDLVKAFMA EIRQYIRELN LIIKVFREPF VSNSKLFSSN 
DVENIFSRIV DIHELSVKLL GHIEDTVEMT DEGSPHPLVG SCFEDLAEEL AFDPYESYAR 
DILRPGFHGH FLSQLSKPGA ALYLQSIGEG FKEAVQYVLP RLLLAPVYHC LHYFELLKQL 
EEKSEDQEDK ECMKQAITAL LNVQSGMEKI CSKSLAKRRL SESACRFYSQ QMKGKQLAIK 
KMNEIQKNID GWEGKDIGQC CNEFIMEGTL TRVGAKHERH IFLFDGLMIC CKSNHGQPRL 
PGASSAEYRL KEKFFMRKVQ INDKDDTSEY KHAFEIILKD GNSVIFSAKS AEEKNNWMAA 
LISLQYRSTL ERMLDVTVLQ EEKEEQMRLP SAEVYRFAEP DSEENILFEE NVQPKAGIPI 
IKAGTVLKLI ERLTYHMYAD PNFVRTFLTT YRSFCRPQEL LSLLIERFEI PEPEPTEADR 
IAIENGDQPL SAELKRFRKE YIQPVQLRVL NVCRHWVEHH FYDFERDADL LQRMEEFIGT 
VRGKAMKKWV ESITKIIQRK KIARDNGPGH NITFQSSPPT VEWHISRPGH IETFDLLTLH 
PIEIARQLTL LESDLYRAVQ PSELVGSVWT KEDKEINSPN LLKMIRHTTN LTLWFEKCIV 
ETENLEERVA VVSRIIEILQ VFQELNNFNG VLEVVSAMNS SPVYRLDHTF EQIPSRQKKI 
LEEAHELSED HYKKYLAKLR SINPPCVPFF GIYLTNILKT EEGNPEVLRR HGKELINFSK 
RRRVAEITGE IQQYQNQPYC LRVEPDIKRF FENLNPMGNS MEKEFTDYLF NKSLEIEPRH 
PKPLPRFPKK YSYPLKSPGV RPSNPRPGTM RHPTPLQQEP RKISYSRIPE SETESTASAP 
NSPRTPLTPP PASGTSSNTD VCSVFDSDHS ASPFHSSKC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Sos1

Associated with

Other Information

Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras. PubMed ID: 1631150

EPS8 and E3B1 transduce signals from Ras to Rac. PubMed ID: 10499589

An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine. PubMed ID: 11524436

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. PubMed ID: 17114649

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The solution structure of the pleckstrin homology domain of mouse Son-of-sevenless 1 (mSos1). PubMed ID: 9217262

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073