Genular: Defining Cellular Identity and Function

Details for: Sox10

Gene ID: 20665

Symbol: Sox10

Ensembl ID: ENSMUSG00000033006

Description: SRY (sex determining region Y)-box 10

Associated with

Cell differentiation
(GO:0030154)
Cell maturation
(GO:0048469)
Central nervous system myelination
(GO:0022010)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Cytoplasm
(GO:0005737)
Developmental growth
(GO:0048589)
Digestive tract morphogenesis
(GO:0048546)
Dna-binding transcription activator activity
(GO:0001216)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription factor binding
(GO:0140297)
Dna binding
(GO:0003677)
Enteric nervous system development
(GO:0048484)
Identical protein binding
(GO:0042802)
In utero embryonic development
(GO:0001701)
Lacrimal gland development
(GO:0032808)
Melanocyte differentiation
(GO:0030318)
Membrane
(GO:0016020)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrion
(GO:0005739)
Morphogenesis of a branching epithelium
(GO:0061138)
Morphogenesis of an epithelium
(GO:0002009)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of schwann cell proliferation
(GO:0010626)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neural crest cell migration
(GO:0001755)
Neuroblast proliferation
(GO:0007405)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Oligodendrocyte development
(GO:0014003)
Oligodendrocyte differentiation
(GO:0048709)
Peripheral nervous system development
(GO:0007422)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of gliogenesis
(GO:0014015)
Positive regulation of myelination
(GO:0031643)
Positive regulation of neuroblast proliferation
(GO:0002052)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Promoter-specific chromatin binding
(GO:1990841)
Protein binding
(GO:0005515)
Regulation of dna-templated transcription
(GO:0006355)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription elongation by rna polymerase ii
(GO:0006368)
Transcription factor binding
(GO:0008134)

Other Information

Proteins

Transcription factor SOX-10

Genular Protein ID: 1394633859

Symbol: SOX10_MOUSE

Name: Transcription factor SOX-10

UniProtKB Accession Codes:

Q04888 O08518 O09141 O54856 P70416

Database IDs:

Citations:

PubMed ID: 9425902

Title: Sox10 mutation disrupts neural crest development in Dom Hirschsprung mouse model.

PubMed ID: 9425902

DOI: 10.1038/ng0198-60

PubMed ID: 9560246

Title: Mutation of the Sry-related Sox10 gene in Dominant megacolon, a mouse model for human Hirschsprung disease.

PubMed ID: 9560246

DOI: 10.1073/pnas.95.9.5161

PubMed ID: 9760192

Title: The SOX10/Sox10 gene from human and mouse: sequence, expression, and transactivation by the encoded HMG domain transcription factor.

PubMed ID: 9760192

DOI: 10.1007/s004390050793

PubMed ID: 9027483

Title: Isolation of a novel Sry-related gene that is expressed in high-metastatic K-1735 murine melanoma cells.

PubMed ID: 9027483

DOI: 10.1006/geno.1996.4483

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8441686

Title: Seven new members of the Sox gene family expressed during mouse development.

PubMed ID: 8441686

DOI: 10.1093/nar/21.3.744

PubMed ID: 8921394

Title: Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth.

PubMed ID: 8921394

DOI: 10.1006/geno.1996.0548

PubMed ID: 19304657

Title: The armadillo repeat-containing protein, ARMCX3, physically and functionally interacts with the developmental regulatory factor Sox10.

PubMed ID: 19304657

DOI: 10.1074/jbc.m901177200

PubMed ID: 24204311

Title: The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes.

PubMed ID: 24204311

DOI: 10.1371/journal.pgen.1003907

PubMed ID: 27532821

Title: The dual-specificity phosphatase Dusp15 is regulated by Sox10 and Myrf in myelinating oligodendrocytes.

PubMed ID: 27532821

DOI: 10.1002/glia.23044

PubMed ID: 26525805

Title: Sox13 functionally complements the related Sox5 and Sox6 as important developmental modulators in mouse spinal cord oligodendrocytes.

PubMed ID: 26525805

DOI: 10.1111/jnc.13414

Sequence Information:

Length: 466
Mass: 49949
Checksum: 84862547F039E71F
Sequence:

MAEEQDLSEV ELSPVGSEEP RCLSPGSAPS LGPDGGGGGS GLRASPGPGE LGKVKKEQQD 
GEADDDKFPV CIREAVSQVL SGYDWTLVPM PVRVNGASKS KPHVKRPMNA FMVWAQAARR 
KLADQYPHLH NAELSKTLGK LWRLLNESDK RPFIEEAERL RMQHKKDHPD YKYQPRRRKN 
GKAAQGEAEC PGGEAEQGGA AAIQAHYKSA HLDHRHPEEG SPMSDGNPEH PSGQSHGPPT 
PPTTPKTELQ SGKADPKRDG RSLGEGGKPH IDFGNVDIGE ISHEVMSNME TFDVTELDQY 
LPPNGHPGHV GSYSAAGYGL GSALAVASGH SAWISKPPGV ALPTVSPPGV DAKAQVKTET 
TGPQGPPHYT DQPSTSQIAY TSLSLPHYGS AFPSISRPQF DYSDHQPSGP YYGHAGQASG 
LYSAFSYMGP SQRPLYTAIS DPSPSGPQSH SPTHWEQPVY TTLSRP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Sox10

Associated with

Other Information

Sox10 mutation disrupts neural crest development in Dom Hirschsprung mouse model. PubMed ID: 9425902

Mutation of the Sry-related Sox10 gene in Dominant megacolon, a mouse model for human Hirschsprung disease. PubMed ID: 9560246

The SOX10/Sox10 gene from human and mouse: sequence, expression, and transactivation by the encoded HMG domain transcription factor. PubMed ID: 9760192

Isolation of a novel Sry-related gene that is expressed in high-metastatic K-1735 murine melanoma cells. PubMed ID: 9027483

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Seven new members of the Sox gene family expressed during mouse development. PubMed ID: 8441686

Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth. PubMed ID: 8921394

The armadillo repeat-containing protein, ARMCX3, physically and functionally interacts with the developmental regulatory factor Sox10. PubMed ID: 19304657

The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes. PubMed ID: 24204311

The dual-specificity phosphatase Dusp15 is regulated by Sox10 and Myrf in myelinating oligodendrocytes. PubMed ID: 27532821

Sox13 functionally complements the related Sox5 and Sox6 as important developmental modulators in mouse spinal cord oligodendrocytes. PubMed ID: 26525805