Details for: Sox11

Gene ID: 20666

Symbol: Sox11

Ensembl ID: ENSMUSG00000063632

Description: SRY (sex determining region Y)-box 11

Associated with

  • Brain development
    (GO:0007420)
  • Camera-type eye morphogenesis
    (GO:0048593)
  • Cell differentiation
    (GO:0030154)
  • Cis-regulatory region sequence-specific dna binding
    (GO:0000987)
  • Closure of optic fissure
    (GO:0061386)
  • Cornea development in camera-type eye
    (GO:0061303)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Embryonic digestive tract morphogenesis
    (GO:0048557)
  • Embryonic skeletal system morphogenesis
    (GO:0048704)
  • Eyelid development in camera-type eye
    (GO:0061029)
  • Glial cell development
    (GO:0021782)
  • Glial cell proliferation
    (GO:0014009)
  • Hard palate development
    (GO:0060022)
  • Lens morphogenesis in camera-type eye
    (GO:0002089)
  • Lung morphogenesis
    (GO:0060425)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of glial cell proliferation
    (GO:0060253)
  • Negative regulation of lymphocyte proliferation
    (GO:0050672)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nervous system development
    (GO:0007399)
  • Neuroepithelial cell differentiation
    (GO:0060563)
  • Neuron differentiation
    (GO:0030182)
  • Noradrenergic neuron differentiation
    (GO:0003357)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Outflow tract morphogenesis
    (GO:0003151)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of bmp signaling pathway
    (GO:0030513)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of hippo signaling
    (GO:0035332)
  • Positive regulation of hormone secretion
    (GO:0046887)
  • Positive regulation of lens epithelial cell proliferation
    (GO:2001111)
  • Positive regulation of neurogenesis
    (GO:0050769)
  • Positive regulation of neuron differentiation
    (GO:0045666)
  • Positive regulation of ossification
    (GO:0045778)
  • Positive regulation of osteoblast differentiation
    (GO:0045669)
  • Positive regulation of stem cell proliferation
    (GO:2000648)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Skeletal muscle cell differentiation
    (GO:0035914)
  • Soft palate development
    (GO:0060023)
  • Spinal cord development
    (GO:0021510)
  • Sympathetic nervous system development
    (GO:0048485)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Ventricular septum morphogenesis
    (GO:0060412)

Other Information

Genular Protein ID: 1284585507

Symbol: SOX11_MOUSE

Name: Transcription factor SOX-11

UniProtKB Accession Codes:

Q7M6Y2 O35178 O89036 Q04889 Q80XF0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 7 Ensembl 1 GO 51 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 3 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 9337129

Title: Expression of the Sox11 gene in mouse embryos suggests roles in neuronal maturation and epithelio-mesenchymal induction.

PubMed ID: 9337129

DOI: 10.1002/(sici)1097-0177(199710)210:2<79::aid-aja1>3.0.co;2-6

PubMed ID: 15456859

Title: Interplay of SOX and POU factors in regulation of the nestin gene in neural primordial cells.

PubMed ID: 15456859

DOI: 10.1128/mcb.24.20.8834-8846.2004

PubMed ID: 12923295

Title: Screening for mammalian neural genes via fluorescence-activated cell sorter purification of neural precursors from Sox1-gfp knock-in mice.

PubMed ID: 12923295

DOI: 10.1073/pnas.1734197100

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8441686

Title: Seven new members of the Sox gene family expressed during mouse development.

PubMed ID: 8441686

DOI: 10.1093/nar/21.3.744

PubMed ID: 15345747

Title: Phosphoproteomic analysis of the developing mouse brain.

PubMed ID: 15345747

DOI: 10.1074/mcp.m400085-mcp200

PubMed ID: 18505825

Title: Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors.

PubMed ID: 18505825

DOI: 10.1128/mcb.00338-08

PubMed ID: 18403418

Title: The three SoxC proteins--Sox4, Sox11 and Sox12--exhibit overlapping expression patterns and molecular properties.

PubMed ID: 18403418

DOI: 10.1093/nar/gkn162

PubMed ID: 20596238

Title: Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors.

PubMed ID: 20596238

DOI: 10.1038/ncomms1008

Sequence Information:

  • Length: 395
  • Mass: 42629
  • Checksum: AFA34270A054C6C5
  • Sequence:
    • MVQQAESSEA ESNLPRDALD TEEGEFMACS PVALDESDPD WCKTASGHIK RPMNAFMVWS 
KIERRKIMEQ SPDMHNAEIS KRLGKRWKML KDSEKIPFIR EAERLRLKHM ADYPDYKYRP 
RKKPKTDPAA KPSAGQSPDK SAAGAKAAKG PGKKCAKLKA PAGKAGAGKA AQPGDCAAGK 
AAKCVFLDDD DEDDDEDDEL QLRPKPDADD DDDEPAHSHL LPPPTQQQPP QLLRRYSVAK 
VPASPTLSSA AESPEGASLY DEVRAGGRLY YSFKNITKQQ PPPAPPALSP ASSRCVSTSS 
SSGSSSGSGA EDADDLMFDL SLNFSQGAHS ACEQPLGAGA AGNLSLSLVD KDLDSFSEGS 
LGSHFEFPDY CTPELSEMIA GDWLEANFSD LVFTY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.