Details for: Sox12

Gene ID: 20667

Symbol: Sox12

Ensembl ID: ENSMUSG00000051817

Description: SRY (sex determining region Y)-box 12

Associated with

  • Brain development
    (GO:0007420)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuron differentiation
    (GO:0030182)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of regulatory t cell differentiation
    (GO:0045591)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein-dna complex
    (GO:0032993)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Spinal cord development
    (GO:0021510)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Other Information

Genular Protein ID: 1156484708

Symbol: SOX12_MOUSE

Name: Transcription factor SOX-12

UniProtKB Accession Codes:

Q04890 A2AS82 P70417 Q6NXL2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 Ensembl 2 GO 14 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 3 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8441686

Title: Seven new members of the Sox gene family expressed during mouse development.

PubMed ID: 8441686

DOI: 10.1093/nar/21.3.744

PubMed ID: 8921394

Title: Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth.

PubMed ID: 8921394

DOI: 10.1006/geno.1996.0548

PubMed ID: 18505825

Title: Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors.

PubMed ID: 18505825

DOI: 10.1128/mcb.00338-08

PubMed ID: 18403418

Title: The three SoxC proteins--Sox4, Sox11 and Sox12--exhibit overlapping expression patterns and molecular properties.

PubMed ID: 18403418

DOI: 10.1093/nar/gkn162

PubMed ID: 20596238

Title: Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors.

PubMed ID: 20596238

DOI: 10.1038/ncomms1008

PubMed ID: 30190287

Title: Sox12 promotes T reg differentiation in the periphery during colitis.

PubMed ID: 30190287

DOI: 10.1084/jem.20172082

Sequence Information:

  • Length: 314
  • Mass: 34083
  • Checksum: CAB9DEF059F2C5A0
  • Sequence:
    • MVQQRGARAK RDGGPPPPGP GPAAEGAREP GWCKTPSGHI KRPMNAFMVW SQHERRKIMD 
QWPDMHNAEI SKRLGRRWQL LQDSEKIPFV REAERLRLKH MADYPDYKYR PRKKSKGAPA 
KARPRPPGGG GGGSRLKPGP QLPGRGGRRA SGGPLGGGAA APEDDDEDEE EELLEVRLLE 
TPGRELWRMV PAGRAARGPA ERAQGPSGEG AAASAASPTL SEDEEPEEEE EEAATAEEGE 
EETVVSGEEP LGFLSRMPPG PAGLDCSALD RDPDLLPPSG TSHFEFPDYC TPEVTEMIAG 
DWRSSSIADL VFTY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.