Details for: Sox13

Gene ID: 20668

Symbol: Sox13

Ensembl ID: ENSMUSG00000070643

Description: SRY (sex determining region Y)-box 13

Associated with

  • Deactivation of the beta-catenin transactivating complex
    (R-MMU-3769402)
  • Signaling by wnt
    (R-MMU-195721)
  • Signal transduction
    (R-MMU-162582)
  • Tcf dependent signaling in response to wnt
    (R-MMU-201681)
  • Cell differentiation
    (GO:0030154)
  • Cell fate commitment
    (GO:0045165)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity
    (GO:0001217)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Gamma-delta t cell differentiation
    (GO:0042492)
  • Identical protein binding
    (GO:0042802)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of brown fat cell differentiation
    (GO:0090336)
  • Positive regulation of gamma-delta t cell differentiation
    (GO:0045588)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of gamma-delta t cell differentiation
    (GO:0045586)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific dna binding
    (GO:0043565)
  • Spinal cord oligodendrocyte cell differentiation
    (GO:0021529)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Other Information

Genular Protein ID: 1881653307

Symbol: SOX13_MOUSE

Name: Transcription factor SOX-13

UniProtKB Accession Codes:

Q04891 Q922L3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 23 Gene3D 1 GeneTree 1 Genevisible 1 InParanoid 1 InterPro 2 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9524265

Title: Cloning and characterization of mouse mSox13 cDNA.

PubMed ID: 9524265

DOI: 10.1016/s0378-1119(97)00667-7

PubMed ID: 9421502

Title: High expression of the HMG box factor sox-13 in arterial walls during embryonic development.

PubMed ID: 9421502

DOI: 10.1093/nar/26.2.469

PubMed ID: 8441686

Title: Seven new members of the Sox gene family expressed during mouse development.

PubMed ID: 8441686

DOI: 10.1093/nar/21.3.744

PubMed ID: 10871192

Title: Sex-determining region Y-related protein SOX13 is a diabetes autoantigen expressed in pancreatic islets.

PubMed ID: 10871192

DOI: 10.2337/diabetes.49.4.555

PubMed ID: 16835393

Title: SOX13 exhibits a distinct spatial and temporal expression pattern during chondrogenesis, neurogenesis, and limb development.

PubMed ID: 16835393

DOI: 10.1369/jhc.6a6923.2006

PubMed ID: 17218525

Title: Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13.

PubMed ID: 17218525

DOI: 10.1126/science.1135344

PubMed ID: 20028982

Title: Interaction between Hhex and SOX13 modulates Wnt/TCF activity.

PubMed ID: 20028982

DOI: 10.1074/jbc.m109.046649

PubMed ID: 23562159

Title: A network of high-mobility group box transcription factors programs innate interleukin-17 production.

PubMed ID: 23562159

DOI: 10.1016/j.immuni.2013.01.010

PubMed ID: 26525805

Title: Sox13 functionally complements the related Sox5 and Sox6 as important developmental modulators in mouse spinal cord oligodendrocytes.

PubMed ID: 26525805

DOI: 10.1111/jnc.13414

PubMed ID: 27923061

Title: Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis.

PubMed ID: 27923061

DOI: 10.1371/journal.pgen.1006474

PubMed ID: 30413363

Title: Interleukin-17-Producing gammadelta T Cells Originate from SOX13+ Progenitors that Are Independent of gammadeltaTCR Signaling.

PubMed ID: 30413363

DOI: 10.1016/j.immuni.2018.09.010

PubMed ID: 30638933

Title: Sox13 is a novel early marker for hair follicle development.

PubMed ID: 30638933

DOI: 10.1016/j.bbrc.2018.12.163

Sequence Information:

  • Length: 613
  • Mass: 68168
  • Checksum: F62C88A052436E91
  • Sequence:
    • MSMQSPVSVQ LAPDSASTMV NCTIKSEEKK EPCHEAPQGA APAVETQPGD PALASQDATN 
AKAPPQDCAS PESSGSPEPK RPAASEAASG SQERLDFNRN LQEVVPAIEK LLSSDWKERF 
LGRSNVEAKD VKGTQESLAE KELQLLVMIH QLSALRDQLL TAHSEQKNMA AMLFEKQQQQ 
MELARQQQEQ IAKQQQQLIQ QQHKINLLQQ QIQQVNMPYV MIPAFPPSHQ PLPVTPDSQL 
ALPIQPIPCK PVEYPLQLLH SPPAPVVKRS GVAAHHPLQE PPQPLNLTAK PKVPELPNTS 
SSPSLKMNSC GPRPASHGAP TRDLQSSPPS LPLGFLGEGD AVTKAIQDAR QLLHSHSGAL 
ENSPNTPFRK DLISLDSSPA KERLEESCVH PLEEAMLSCD MDGSRHFSES RNSSHIKRPM 
NAFMVWAKDE RRKILQAFPD MHNSSISKIL GSRWKSMTNQ EKQPYYEEQA RLSRQHLEKY 
PDYKYKPRPK RTCVVEGRRL RVGEYKALMR TRRQGARQSY TIPPQAGQAQ VSSDILFPRA 
AGLPLARPLV EHYDPQGLDP NMPVIINTCS LREEGEGTDD RHSVADGEMY RYSEDEDSEG 
DEKSDEELVV LTD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.