Genular: Defining Cellular Identity and Function

Details for: Sox17

Gene ID: 20671

Symbol: Sox17

Ensembl ID: ENSMUSG00000025902

Description: SRY (sex determining region Y)-box 17

Associated with

Deactivation of the beta-catenin transactivating complex
(R-MMU-3769402)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Angiogenesis
(GO:0001525)
Beta-catenin binding
(GO:0008013)
Cardiac cell fate determination
(GO:0060913)
Cardiogenic plate morphogenesis
(GO:0003142)
Cell migration involved in gastrulation
(GO:0042074)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Common bile duct development
(GO:0061009)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Embryonic foregut morphogenesis
(GO:0048617)
Embryonic heart tube development
(GO:0035050)
Embryonic heart tube morphogenesis
(GO:0003143)
Embryonic organ development
(GO:0048568)
Endocardial cell differentiation
(GO:0060956)
Endocardium formation
(GO:0060214)
Endodermal cell differentiation
(GO:0035987)
Endodermal cell fate determination
(GO:0007493)
Endodermal cell fate specification
(GO:0001714)
Endodermal digestive tract morphogenesis
(GO:0061031)
Endoderm development
(GO:0007492)
Endoderm formation
(GO:0001706)
Gallbladder development
(GO:0061010)
Gastrulation
(GO:0007369)
Gene expression
(GO:0010467)
Heart development
(GO:0007507)
Heart looping
(GO:0001947)
Inner cell mass cellular morphogenesis
(GO:0001828)
Metanephros development
(GO:0001656)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of wnt signaling pathway
(GO:0030178)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Outflow tract morphogenesis
(GO:0003151)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of endodermal cell differentiation
(GO:1903226)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of protein catabolic process
(GO:0045732)
Positive regulation of stem cell differentiation
(GO:2000738)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein destabilization
(GO:0031648)
Protein stabilization
(GO:0050821)
Regulation of cardiac cell fate specification
(GO:2000043)
Regulation of cell differentiation
(GO:0045595)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of embryonic development
(GO:0045995)
Regulation of stem cell division
(GO:2000035)
Regulation of stem cell proliferation
(GO:0072091)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rostrocaudal neural tube patterning
(GO:0021903)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Signal transduction involved in regulation of gene expression
(GO:0023019)
Spermatogenesis
(GO:0007283)
Stem cell differentiation
(GO:0048863)
Stem cell fate specification
(GO:0048866)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription regulator complex
(GO:0005667)
Ureter development
(GO:0072189)
Vasculogenesis
(GO:0001570)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

Transcription factor SOX-17
A0A0A6YXS3_MOUSE

Genular Protein ID: 2392571727

Symbol: SOX17_MOUSE

Name: Transcription factor SOX-17

UniProtKB Accession Codes:

Q61473 Q61472 Q62248

Database IDs:

Citations:

PubMed ID: 8636240

Title: Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis.

PubMed ID: 8636240

DOI: 10.1083/jcb.133.3.667

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 11973269

Title: Depletion of definitive gut endoderm in Sox17-null mutant mice.

PubMed ID: 11973269

DOI: 10.1242/dev.129.10.2367

PubMed ID: 16895970

Title: Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice.

PubMed ID: 16895970

DOI: 10.1242/jcs.03081

PubMed ID: 17655922

Title: Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells.

PubMed ID: 17655922

DOI: 10.1016/j.cell.2007.06.011

PubMed ID: 20802155

Title: Sox17 modulates Wnt3A/beta-catenin-mediated transcriptional activation of the Lef-1 promoter.

PubMed ID: 20802155

DOI: 10.1152/ajplung.00140.2010

PubMed ID: 24153254

Title: Sox17 is indispensable for acquisition and maintenance of arterial identity.

PubMed ID: 24153254

DOI: 10.1038/ncomms3609

PubMed ID: 19328208

Title: The structure of Sox17 bound to DNA reveals a conserved bending topology but selective protein interaction platforms.

PubMed ID: 19328208

DOI: 10.1016/j.jmb.2009.03.055

Sequence Information:

Length: 419
Mass: 44646
Checksum: 14233EED2CCDD69D
Sequence:

MSSPDAGYAS DDQSQPRSAQ PAVMAGLGPC PWAESLSPLG DVKVKGEVVA SSGAPAGTSG 
RAKAESRIRR PMNAFMVWAK DERKRLAQQN PDLHNAELSK MLGKSWKALT LAEKRPFVEE 
AERLRVQHMQ DHPNYKYRPR RRKQVKRMKR VEGGFLHALV EPQAGALGPE GGRVAMDGLG 
LPFPEPGYPA GPPLMSPHMG PHYRDCQGLG APALDGYPLP TPDTSPLDGV EQDPAFFAAP 
LPGDCPAAGT YTYAPVSDYA VSVEPPAGPM RVGPDPSGPA MPGILAPPSA LHLYYGAMGS 
PAASAGRGFH AQPQQPLQPQ APPPPPQQQH PAHGPGQPSP PPEALPCRDG TESNQPTELL 
GEVDRTEFEQ YLPFVYKPEM GLPYQGHDCG VNLSDSHGAI SSVVSDASSA VYYCNYPDI

Genular Protein ID: 2616840248

Symbol: A0A0A6YXS3_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A0A6YXS3

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 354
Mass: 38244
Checksum: DE5BBE57D9DA758F
Sequence:

MSPHGYNEQH LQTSEFQPSY FPKRSWRQRP APASFPQGKS WKALTLAEKR PFVEEAERLR 
VQHMQDHPNY KYRPRRRKQV KRMKRVEGGF LHALVEPQAG ALGPEGGRVA MDGLGLPFPE 
PGYPAGPPLM SPHMGPHYRD CQGLGAPALD GYPLPTPDTS PLDGVEQDPA FFAAPLPGDC 
PAAGTYTYAP VSDYAVSVEP PAGPMRVGPD PSGPAMPGIL APPSALHLYY GAMGSPAASA 
GRGFHAQPQQ PLQPQAPPPP PQQQHPAHGP GQPSPPPEAL PCRDGTESNQ PTELLGEVDR 
TEFEQYLPFV YKPEMGLPYQ GHDCGVNLSD SHGAISSVVS DASSAVYYCN YPDI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Sox17

Associated with

Other Information

Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis. PubMed ID: 8636240

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Depletion of definitive gut endoderm in Sox17-null mutant mice. PubMed ID: 11973269

Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice. PubMed ID: 16895970

Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. PubMed ID: 17655922

Sox17 modulates Wnt3A/beta-catenin-mediated transcriptional activation of the Lef-1 promoter. PubMed ID: 20802155

Sox17 is indispensable for acquisition and maintenance of arterial identity. PubMed ID: 24153254

The structure of Sox17 bound to DNA reveals a conserved bending topology but selective protein interaction platforms. PubMed ID: 19328208

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303