Genular: Defining Cellular Identity and Function

Details for: Sox18

Gene ID: 20672

Symbol: Sox18

Ensembl ID: ENSMUSG00000046470

Description: SRY (sex determining region Y)-box 18

Associated with

Angiogenesis
(GO:0001525)
Blood vessel development
(GO:0001568)
Cell maturation
(GO:0048469)
Chromatin
(GO:0000785)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Embryonic heart tube development
(GO:0035050)
Endocardial cell differentiation
(GO:0060956)
Endocardium formation
(GO:0060214)
Establishment of endothelial barrier
(GO:0061028)
Hair cycle process
(GO:0022405)
Hair follicle development
(GO:0001942)
Heart development
(GO:0007507)
In utero embryonic development
(GO:0001701)
Lymphangiogenesis
(GO:0001946)
Lymphatic endothelial cell differentiation
(GO:0060836)
Lymph vessel development
(GO:0001945)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of stem cell proliferation
(GO:0072091)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Stem cell fate specification
(GO:0048866)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription regulator complex
(GO:0005667)
Vasculature development
(GO:0001944)
Vasculogenesis
(GO:0001570)

Other Information

Proteins

Transcription factor SOX-18

Genular Protein ID: 4031684443

Symbol: SOX18_MOUSE

Name: Transcription factor SOX-18

UniProtKB Accession Codes:

P43680 Q3UND6 Q9EQ73

Database IDs:

Citations:

PubMed ID: 7665083

Title: Sequence and expression of Sox-18 encoding a new HMG-box transcription factor.

PubMed ID: 7665083

DOI: 10.1016/0378-1119(95)00280-j

PubMed ID: 11130989

Title: Structure, mapping, and expression of human SOX18.

PubMed ID: 11130989

DOI: 10.1007/s003350010216

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7651823

Title: Trans-activation and DNA-binding properties of the transcription factor, Sox-18.

PubMed ID: 7651823

DOI: 10.1093/nar/23.14.2626

PubMed ID: 11094083

Title: Mice null for sox18 are viable and display a mild coat defect.

PubMed ID: 11094083

DOI: 10.1128/mcb.20.24.9331-9336.2000

PubMed ID: 10742113

Title: Mutations in Sox18 underlie cardiovascular and hair follicle defects in ragged mice.

PubMed ID: 10742113

DOI: 10.1038/74301

PubMed ID: 11554755

Title: SOX18 directly interacts with MEF2C in endothelial cells.

PubMed ID: 11554755

DOI: 10.1006/bbrc.2001.5589

PubMed ID: 12748961

Title: Sox18 mutations in the ragged mouse alleles ragged-like and opossum.

PubMed ID: 12748961

DOI: 10.1002/gene.10190

PubMed ID: 16895970

Title: Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice.

PubMed ID: 16895970

DOI: 10.1242/jcs.03081

PubMed ID: 18931657

Title: Sox18 induces development of the lymphatic vasculature in mice.

PubMed ID: 18931657

DOI: 10.1038/nature07391

PubMed ID: 19429912

Title: Vascular defects in a mouse model of hypotrichosis-lymphedema-telangiectasia syndrome indicate a role for SOX18 in blood vessel maturation.

PubMed ID: 19429912

DOI: 10.1093/hmg/ddp219

PubMed ID: 26939885

Title: Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction.

PubMed ID: 26939885

DOI: 10.1093/nar/gkw130

Sequence Information:

Length: 377
Mass: 40898
Checksum: 29F4C9B9D50F94D0
Sequence:

MQRSPPGYGA QDDPPSRRDC AWAPGIGAAA EARGLPVTNV SPTSPASPSS LPRSPPRSPE 
SGRYGFGRGE RQTADELRIR RPMNAFMVWA KDERKRLAQQ NPDLHNAVLS KMLGKAWKEL 
NTAEKRPFVE EAERLRVQHL RDHPNYKYRP RRKKQARKVR RLEPGLLLPG LVQPSAPPEA 
FAAASGSARS FRELPTLGAE FDGLGLPTPE RSPLDGLEPG EASFFPPPLA PEDCALRAFR 
APYAPELARD PSFCYGAPLA EALRTAPPAA PLAGLYYGTL GTPGPFPNPL SPPPESPSLE 
GTEQLEPTAD LWADVDLTEF DQYLNCSRTR PDATTLPYHV ALAKLGPRAM SCPEESSLIS 
ALSDASSAVY YSACISG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Sox18

Associated with

Other Information

Sequence and expression of Sox-18 encoding a new HMG-box transcription factor. PubMed ID: 7665083

Structure, mapping, and expression of human SOX18. PubMed ID: 11130989

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Trans-activation and DNA-binding properties of the transcription factor, Sox-18. PubMed ID: 7651823

Mice null for sox18 are viable and display a mild coat defect. PubMed ID: 11094083

Mutations in Sox18 underlie cardiovascular and hair follicle defects in ragged mice. PubMed ID: 10742113

SOX18 directly interacts with MEF2C in endothelial cells. PubMed ID: 11554755

Sox18 mutations in the ragged mouse alleles ragged-like and opossum. PubMed ID: 12748961

Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice. PubMed ID: 16895970

Sox18 induces development of the lymphatic vasculature in mice. PubMed ID: 18931657

Vascular defects in a mouse model of hypotrichosis-lymphedema-telangiectasia syndrome indicate a role for SOX18 in blood vessel maturation. PubMed ID: 19429912

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction. PubMed ID: 26939885