Details for: Sox2

Gene ID: 20674

Symbol: Sox2

Ensembl ID: ENSMUSG00000074637

Description: SRY (sex determining region Y)-box 2

Associated with

  • Adenohypophysis development
    (GO:0021984)
  • Anatomical structure formation involved in morphogenesis
    (GO:0048646)
  • Brain development
    (GO:0007420)
  • Cell fate commitment
    (GO:0045165)
  • Cell fate specification
    (GO:0001708)
  • Cellular response to cadmium ion
    (GO:0071276)
  • Cerebral cortex development
    (GO:0021987)
  • Chromatin
    (GO:0000785)
  • Chromatin binding
    (GO:0003682)
  • Chromatin dna binding
    (GO:0031490)
  • Detection of mechanical stimulus involved in equilibrioception
    (GO:0050973)
  • Detection of mechanical stimulus involved in sensory perception of sound
    (GO:0050910)
  • Diencephalon morphogenesis
    (GO:0048852)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription factor binding
    (GO:0140297)
  • Dna binding
    (GO:0003677)
  • Embryonic organ development
    (GO:0048568)
  • Endodermal cell fate specification
    (GO:0001714)
  • Epithelial tube branching involved in lung morphogenesis
    (GO:0060441)
  • Forebrain development
    (GO:0030900)
  • Forebrain neuron differentiation
    (GO:0021879)
  • Gene expression
    (GO:0010467)
  • Inner ear development
    (GO:0048839)
  • Inner ear morphogenesis
    (GO:0042472)
  • Lens induction in camera-type eye
    (GO:0060235)
  • Lung alveolus development
    (GO:0048286)
  • Male genitalia development
    (GO:0030539)
  • Mirna binding
    (GO:0035198)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of cell cycle g1/s phase transition
    (GO:1902807)
  • Negative regulation of cell differentiation
    (GO:0045596)
  • Negative regulation of epithelial cell proliferation
    (GO:0050680)
  • Negative regulation of neuron differentiation
    (GO:0045665)
  • Negative regulation of osteoblast differentiation
    (GO:0045668)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of wnt signaling pathway
    (GO:0030178)
  • Neuroblast proliferation
    (GO:0007405)
  • Neuronal stem cell population maintenance
    (GO:0097150)
  • Neuron differentiation
    (GO:0030182)
  • Neuron fate commitment
    (GO:0048663)
  • Notch signaling pathway
    (GO:0007219)
  • Nucleus
    (GO:0005634)
  • Olfactory placode formation
    (GO:0030910)
  • Osteoblast differentiation
    (GO:0001649)
  • Pigment biosynthetic process
    (GO:0046148)
  • Positive regulation of cell-cell adhesion
    (GO:0022409)
  • Positive regulation of cell differentiation
    (GO:0045597)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of epithelial cell differentiation
    (GO:0030858)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of neuroblast proliferation
    (GO:0002052)
  • Positive regulation of neuron differentiation
    (GO:0045666)
  • Positive regulation of notch signaling pathway
    (GO:0045747)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043281)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of myofibroblast cell apoptotic process
    (GO:1904520)
  • Regulation of neurogenesis
    (GO:0050767)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to growth factor
    (GO:0070848)
  • Response to organic substance
    (GO:0010033)
  • Response to oxygen-glucose deprivation
    (GO:0090649)
  • Response to retinoic acid
    (GO:0032526)
  • Retina morphogenesis in camera-type eye
    (GO:0060042)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sensory perception of sound
    (GO:0007605)
  • Sequence-specific dna binding
    (GO:0043565)
  • Somatic stem cell population maintenance
    (GO:0035019)
  • Stem cell differentiation
    (GO:0048863)
  • Stem cell population maintenance
    (GO:0019827)
  • Tongue development
    (GO:0043586)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Trophectodermal cell differentiation
    (GO:0001829)
  • Wnt signaling pathway
    (GO:0016055)

Other Information

Genular Protein ID: 1342933448

Symbol: SOX2_MOUSE

Name: Transcription factor SOX-2

UniProtKB Accession Codes:

P48432

Database IDs:

AGR 1 AlphaFoldDB 1 BMRB 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 DIP 1 DNASU 1 EMBL 2 EvolutionaryTrace 1 GO 80 Gene3D 1 GlyGen 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 UniProtKB 3 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 7590241

Title: Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3.

PubMed ID: 7590241

DOI: 10.1101/gad.9.21.2635

PubMed ID: 8625802

Title: A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2.

PubMed ID: 8625802

DOI: 10.1242/dev.122.2.509

PubMed ID: 15863505

Title: Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells.

PubMed ID: 15863505

DOI: 10.1074/jbc.m501423200

PubMed ID: 17097055

Title: Inhibition of DNA binding of Sox2 by the SUMO conjugation.

PubMed ID: 17097055

DOI: 10.1016/j.bbrc.2006.10.130

PubMed ID: 16904174

Title: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

PubMed ID: 16904174

DOI: 10.1016/j.cell.2006.07.024

PubMed ID: 17728342

Title: SOX3 activity during pharyngeal segmentation is required for craniofacial morphogenesis.

PubMed ID: 17728342

DOI: 10.1242/dev.007906

PubMed ID: 19740739

Title: Zfp206, Oct4, and Sox2 are integrated components of a transcriptional regulatory network in embryonic stem cells.

PubMed ID: 19740739

DOI: 10.1074/jbc.m109.016162

PubMed ID: 19349578

Title: Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factors.

PubMed ID: 19349578

DOI: 10.1083/jcb.200810106

PubMed ID: 22198669

Title: Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2.

PubMed ID: 22198669

DOI: 10.1038/nature10712

PubMed ID: 29358331

Title: LSD1 demethylase and the methyl-binding protein PHF20L1 prevent SET7 methyltransferase-dependent proteolysis of the stem-cell protein SOX2.

PubMed ID: 29358331

DOI: 10.1074/jbc.ra117.000342

PubMed ID: 30442713

Title: Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4-DCAF5 ubiquitin ligase.

PubMed ID: 30442713

DOI: 10.1074/jbc.ra118.005336

PubMed ID: 32758484

Title: Keratin 13 deficiency causes white sponge nevus in mice.

PubMed ID: 32758484

DOI: 10.1016/j.ydbio.2020.07.016

PubMed ID: 32127020

Title: Tsukushi is essential for the development of the inner ear.

PubMed ID: 32127020

DOI: 10.1186/s13041-020-00570-z

PubMed ID: 32703285

Title: Ddx56 maintains proliferation of mouse embryonic stem cells via ribosome assembly and interaction with the Oct4/Sox2 complex.

PubMed ID: 32703285

DOI: 10.1186/s13287-020-01800-w

Sequence Information:

  • Length: 319
  • Mass: 34454
  • Checksum: C40DE49E524C49F1
  • Sequence:
    • MYNMMETELK PPGPQQASGG GGGGGNATAA ATGGNQKNSP DRVKRPMNAF MVWSRGQRRK 
MAQENPKMHN SEISKRLGAE WKLLSETEKR PFIDEAKRLR ALHMKEHPDY KYRPRRKTKT 
LMKKDKYTLP GGLLAPGGNS MASGVGVGAG LGGGLNQRMD SYAHMNGWSN GSYSMMQEQL 
GYPQHPGLNA HGAAQMQPMH RYVVSALQYN SMTSSQTYMN GSPTYSMSYS QQGTPGMALG 
SMGSVVKSEA SSSPPVVTSS SHSRAPCQAG DLRDMISMYL PGAEVPEPAA PSRLHMAQHY 
QSGPVPGTAK YGTLPLSHM

Genular Protein ID: 365578442

Symbol: Q60I23_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q60I23

Database IDs:

AGR 1 ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 4 Ensembl 2 GO 22 Gene3D 1 GeneTree 1 HOGENOM 1 IntAct 1 InterPro 3 KEGG 1 MGI 2 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15456859

Title: Interplay of SOX and POU factors in regulation of the nestin gene in neural primordial cells.

PubMed ID: 15456859

DOI: 10.1128/MCB.24.20.8834-8846.2004

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 319
  • Mass: 34406
  • Checksum: 07A6DFDCA205991F
  • Sequence:
    • MYNMMETELK PPGPQQASGG GGGGGNATAA ATGGNQKNSP DRVKRPMNAF MVWSRGQRRK 
MAQENPKMHN SEISKRLGAE WKLLSETEKR PFIDEAKRLR ALHMKEHPDY KYRPRRKTKT 
LMKKDKYTLP GGLLAPGGNS MASGVGVGAG LGAGVNQRMD SYAHMNGWSN GSYSMMQEQL 
GYPQHPGLNA HGAAQMQPMH RYDVSALQYN SMTSSQTYMN GSPTYSMSYS QQGTPGMALG 
SMGSVVKSEA SSSPPVVTSS SHSRAPCQAG DLRDMISMYL PGAEVPEPAA PSRLHMAQHY 
QSGPVPGTAI NGTLPLSHM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.