Genular: Defining Cellular Identity and Function

Details for: Sox4

Gene ID: 20677

Symbol: Sox4

Ensembl ID: ENSMUSG00000076431

Description: SRY (sex determining region Y)-box 4

Associated with

Deactivation of the beta-catenin transactivating complex
(R-MMU-3769402)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Ascending aorta morphogenesis
(GO:0035910)
Atrial septum primum morphogenesis
(GO:0003289)
Brain development
(GO:0007420)
Camera-type eye morphogenesis
(GO:0048593)
Cardiac right ventricle morphogenesis
(GO:0003215)
Cellular response to glucose stimulus
(GO:0071333)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Endocrine pancreas development
(GO:0031018)
Gene expression
(GO:0010467)
Glial cell development
(GO:0021782)
Glial cell proliferation
(GO:0014009)
Glucose homeostasis
(GO:0042593)
Heart development
(GO:0007507)
Hematopoietic stem cell homeostasis
(GO:0061484)
Kidney morphogenesis
(GO:0060993)
Mesenchyme development
(GO:0060485)
Mirna binding
(GO:0035198)
Mitochondrion
(GO:0005739)
Mitral valve morphogenesis
(GO:0003183)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of myoblast differentiation
(GO:0045662)
Negative regulation of protein ubiquitination
(GO:0031397)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nervous system development
(GO:0007399)
Neuroepithelial cell differentiation
(GO:0060563)
Neuron differentiation
(GO:0030182)
Noradrenergic neuron differentiation
(GO:0003357)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gamma-delta t cell differentiation
(GO:0045588)
Positive regulation of insulin secretion
(GO:0032024)
Positive regulation of myoblast differentiation
(GO:0045663)
Positive regulation of n-terminal peptidyl-lysine acetylation
(GO:2000761)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of translation
(GO:0045727)
Pro-b cell differentiation
(GO:0002328)
Protein binding
(GO:0005515)
Protein stabilization
(GO:0050821)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of dna damage response, signal transduction by p53 class mediator
(GO:0043516)
Regulation of protein stability
(GO:0031647)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific double-stranded dna binding
(GO:1990837)
Somatic stem cell population maintenance
(GO:0035019)
Spinal cord development
(GO:0021510)
Sympathetic nervous system development
(GO:0048485)
T cell differentiation
(GO:0030217)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription regulator complex
(GO:0005667)
Ventricular septum morphogenesis
(GO:0060412)

Other Information

Proteins

SOX4_MOUSE

Genular Protein ID: 939536678

Symbol: SOX4_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q06831 Q5SW95

Database IDs:

Citations:

PubMed ID: 8404853

Title: Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes.

PubMed ID: 8404853

DOI: 10.1002/j.1460-2075.1993.tb06063.x

PubMed ID: 8493110

Title: The murine Sox-4 protein is encoded on a single exon.

PubMed ID: 8493110

DOI: 10.1093/nar/21.8.2009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8921394

Title: Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth.

PubMed ID: 8921394

DOI: 10.1006/geno.1996.0548

PubMed ID: 15345747

Title: Phosphoproteomic analysis of the developing mouse brain.

PubMed ID: 15345747

DOI: 10.1074/mcp.m400085-mcp200

PubMed ID: 17218525

Title: Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13.

PubMed ID: 17218525

DOI: 10.1126/science.1135344

PubMed ID: 23562159

Title: A network of high-mobility group box transcription factors programs innate interleukin-17 production.

PubMed ID: 23562159

DOI: 10.1016/j.immuni.2013.01.010

PubMed ID: 26291311

Title: KAT5-mediated SOX4 acetylation orchestrates chromatin remodeling during myoblast differentiation.

PubMed ID: 26291311

DOI: 10.1038/cddis.2015.190

Sequence Information:

Length: 440
Mass: 45044
Checksum: 979AADBA7F674B6D
Sequence:

MVQQTNNAEN TEALLAGESS DSGAGLELGI ASSPTPGSTA STGGKADDPS WCKTPSGHIK 
RPMNAFMVWS QIERRKIMEQ SPDMHNAEIS KRLGKRWKLL KDSDKIPFIQ EAERLRLKHM 
ADYPDYKYRP RKKVKSGNAG AGSAATAKPG EKGDKVAGSS GHAGSSHAGG GAGGSSKPAP 
KKSCGPKVAG SSVGKPHAKL VPAGGSKAAA SFSPEQAALL PLGEPTAVYK VRTPSAATPA 
ASSSPSSALA TPAKHPADKK VKRVYLFGSL GASASPVGGL GASADPSDPL GLYEDGGPGC 
SPDGRSLSGR SSAASSPAAS RSPADHRGYA SLRAASPAPS SAPSHASSSL SSSSSSSSGS 
SSSDDEFEDD LLDLNPSSNF ESMSLGSFSS SSALDRDLDF NFEPGSGSHF EFPDYCTPEV 
SEMISGDWLE SSISNLVFTY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Sox4

Associated with

Other Information

Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes. PubMed ID: 8404853

The murine Sox-4 protein is encoded on a single exon. PubMed ID: 8493110

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth. PubMed ID: 8921394

Phosphoproteomic analysis of the developing mouse brain. PubMed ID: 15345747

Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13. PubMed ID: 17218525

A network of high-mobility group box transcription factors programs innate interleukin-17 production. PubMed ID: 23562159

KAT5-mediated SOX4 acetylation orchestrates chromatin remodeling during myoblast differentiation. PubMed ID: 26291311