Details for: Sox5

Gene ID: 20678

Symbol: Sox5

Ensembl ID: ENSMUSG00000041540

Description: SRY (sex determining region Y)-box 5

Associated with

  • Asymmetric neuroblast division
    (GO:0055059)
  • Cartilage condensation
    (GO:0001502)
  • Cartilage development
    (GO:0051216)
  • Cell differentiation
    (GO:0030154)
  • Cell fate commitment
    (GO:0045165)
  • Cellular response to transforming growth factor beta stimulus
    (GO:0071560)
  • Central nervous system neuron differentiation
    (GO:0021953)
  • Chondrocyte differentiation
    (GO:0002062)
  • Cis-regulatory region sequence-specific dna binding
    (GO:0000987)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • In utero embryonic development
    (GO:0001701)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Nucleus
    (GO:0005634)
  • Oligodendrocyte differentiation
    (GO:0048709)
  • Positive regulation of cartilage development
    (GO:0061036)
  • Positive regulation of chondrocyte differentiation
    (GO:0032332)
  • Positive regulation of mesenchymal stem cell differentiation
    (GO:2000741)
  • Protein binding
    (GO:0005515)
  • Regulation of timing of neuron differentiation
    (GO:0060164)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription regulator complex
    (GO:0005667)

Other Information

Genular Protein ID: 2566795961

Symbol: SOX5_MOUSE

Name: N/A

UniProtKB Accession Codes:

P35710 O88184 O89018

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 3 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 EMBL 4 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 1396566

Title: An SRY-related gene expressed during spermatogenesis in the mouse encodes a sequence-specific DNA-binding protein.

PubMed ID: 1396566

DOI: 10.1002/j.1460-2075.1992.tb05455.x

PubMed ID: 9714725

Title: The mouse Sox5 gene encodes a protein containing the leucine zipper and the Q box.

PubMed ID: 9714725

DOI: 10.1016/s0167-4781(98)00086-4

PubMed ID: 9755172

Title: A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene.

PubMed ID: 9755172

DOI: 10.1093/emboj/17.19.5718

PubMed ID: 8078769

Title: DNA binding and bending properties of the post-meiotically expressed Sry-related protein Sox-5.

PubMed ID: 8078769

DOI: 10.1093/nar/22.16.3339

PubMed ID: 11702786

Title: The transcription factors L-Sox5 and Sox6 are essential for cartilage formation.

PubMed ID: 11702786

DOI: 10.1016/s1534-5807(01)00003-x

PubMed ID: 12414734

Title: The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6.

PubMed ID: 12414734

DOI: 10.1101/gad.1017802

PubMed ID: 15529345

Title: The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage.

PubMed ID: 15529345

DOI: 10.1002/art.20611

PubMed ID: 14993235

Title: Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate.

PubMed ID: 14993235

DOI: 10.1083/jcb.200312045

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 26150426

Title: The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis.

PubMed ID: 26150426

DOI: 10.1093/nar/gkv688

PubMed ID: 26525805

Title: Sox13 functionally complements the related Sox5 and Sox6 as important developmental modulators in mouse spinal cord oligodendrocytes.

PubMed ID: 26525805

DOI: 10.1111/jnc.13414

PubMed ID: 27923061

Title: Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis.

PubMed ID: 27923061

DOI: 10.1371/journal.pgen.1006474

PubMed ID: 11266597

Title: Solution structure and backbone dynamics of the DNA-binding domain of mouse Sox-5.

PubMed ID: 11266597

DOI: 10.1110/ps.32801

Sequence Information:

  • Length: 763
  • Mass: 84090
  • Checksum: E38B1470ECCB1DE7
  • Sequence:
    • MLTDPDLPQE FERMSSKRPA SPYGETDGEV AMVTSRQKVE EEESERLPAF HLPLHVSFPN 
KPHSEEFQPV SLLTQETCGP RTPTVQHNTM EVDGNKVMSS LSPYNSSTSP QKAEEGGRQS 
GESVSSAALG TPERRKGSLA DVVDTLKQRK MEELIKNEPE DTPSIEKLLS KDWKDKLLAM 
GSGNFGEIKG TPESLAEKER QLMGMINQLT SLREQLLAAH DEQKKLAASQ IEKQRQQMEL 
AKQQQEQIAR QQQQLLQQQH KINLLQQQIQ VQGQLPPLMI PVFPPDQRTL AAAAQQGFLL 
PPGFSYKAGC SDPYPVQLIP TTMAAAAAAT PGLGPLQLQQ FYAAQLAAMQ VSPGGKLLGL 
PQGNLGAAVS PTSIHTDKST NSPPPKSKDE VAQPLNLSAK PKTSDGKSPA SPTSPHMPAL 
RINSGAGPLK ASVPAALASP SARVSTIGYL NDHDAVTKAI QEARQMKEQL RREQQALDGK 
VAVVNSIGLS NCRTEKEKTT LESLTQQLAV KQNEEGKFSH GMMDFNMSGD SDGSAGVSES 
RIYRESRGRG SNEPHIKRPM NAFMVWAKDE RRKILQAFPD MHNSNISKIL GSRWKAMTNL 
EKQPYYEEQA RLSKQHLEKY PDYKYKPRPK RTCLVDGKKL RIGEYKAIMR NRRQEMRQYF 
NVGQQAQIPI ATAGVVYPSA IAMAGMPSPH LPSEHSSVSS SPEPGMPVIQ STYGAKGEEP 
HIKEEIQAED INGEIYEEYD EEEEDPDVDY GSDSENHIAG QAN

Genular Protein ID: 494001644

Symbol: Q3TVF9_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3TVF9

Database IDs:

AGR 1 ARBA 4 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 2 Gene3D 1 HOGENOM 1 InterPro 2 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 Pfam 1 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 392
  • Mass: 43234
  • Checksum: BF6A679800F916C8
  • Sequence:
    • MAAAAAATPG LGPLQLQDEV AQPLNLSAKP KTSDGKSPAS PTSPHMPALR INSGAGPLKA 
SVPAALASPS ARVSTIGYLN DHDAVTKAIQ EARQMKEQLR REQQALDGKV AVVNSIGLSN 
CRTEKEKTTL ESLTQQLAVK QNEEGKFSHG MMDFNMSGDS DGSAGVSESR IYRESRGRGS 
NEPHIKRPMN AFMVWAKDER RKILQAFPDM HNSNISKILG SRWKAMTNLE KQPYYEEQAR 
LSKQHLEKYP DYKYKPRPKR TCLVDGKKLR IGEYKAIMRN RRQEMRQYFN VGQQAQIPIA 
TAGVVYPSAI AMAGMPSPHL PSEHSSVSSS PEPGMPVIQS TYGAKGEEPH IKEEIQAEDI 
NGEIYEEYDE EEEDPDVDYG SDSENHIAGQ AN

Genular Protein ID: 19989603

Symbol: B2KFM4_MOUSE

Name: N/A

UniProtKB Accession Codes:

B2KFM4

Database IDs:

AGR 1 ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InterPro 2 KEGG 1 MGI 2 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1 jPOST 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 679
  • Mass: 75209
  • Checksum: D638BF4CC26B842A
  • Sequence:
    • MLTDPDLPQE FERMSSKRPA SPYGETDGEV AMVTSRQKVE EEESERLPAF HLPLHEVDGN 
KVMSSLAPYN SSTSPQKAEE GGRQSGESVS SAALGTPERR KGSLADVVDT LKQRKMEELI 
KNEPEDTPSI EKLLSKDWKD KLLAMGSGNF GEIKGTPESL AEKERQLMGM INQLTSLREQ 
LLAAHDEQKK LAASQIEKQR QQMELAKQQQ EQIARQQQQL LQQQHKINLL QQQIQVQGQL 
PPLMIPVFPP DQRTLAAAAQ QGFLLPPGFS YKAGCSDPYP VQLIPTTMAA AAAATPGLGP 
LQLQDEVAQP LNLSAKPKTS DGKSPASPTS PHMPALRINS GAGPLKASVP AALASPSARV 
STIGYLNDHD AVTKAIQEAR QMKEQLRREQ QALDGKVAVV NSIGLSNCRT EKEKTTLESL 
TQQLAVKQNE EGKFSHGMMD FNMSGDSDGS AGVSESRIYR ESRGRGSNEP HIKRPMNAFM 
VWAKDERRKI LQAFPDMHNS NISKILGSRW KAMTNLEKQP YYEEQARLSK QHLEKYPDYK 
YKPRPKRTCL VDGKKLRIGE YKAIMRNRRQ EMRQYFNVGQ QAQIPIATAG VVYPSAIAMA 
GMPSPHLPSE HSSVSSSPEP GMPVIQSTYG AKGEEPHIKE EIQAEDINGE IYEEYDEEEE 
DPDVDYGSDS ENHIAGQAN

Genular Protein ID: 3194392791

Symbol: Q8C4K8_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8C4K8

Database IDs:

AGR 1 ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Genevisible 1 Google 1 KEGG 1 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 RefSeq 2 SAM 2 UCSC 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 346
  • Mass: 37499
  • Checksum: C39E1AD2DAE8F2DD
  • Sequence:
    • MSSKRPASPY GETDGEVAMV TSRQKVEEEE SERLPAFHLP LHEVDGNKVM SSLAPYNSST 
SPQKAEEGGR QSGESVSSAA LGTPERRKGS LADVVDTLKQ RKMEELIKNE PEDTPSIEKL 
LSKDWKDKLL AMGSGNFGEI KGTPESLAEK ERQLMGMINQ LTSLREQLLA AHDEQKKLAA 
SQIEKQRQQM ELAKQQQEQI ARQQQQLLQQ QHKINLLQQQ IQVQGQLPPL MIPVFPPDQR 
TLAAAAQQGF LLPPGFSYKA GCSDPYPVQL IPTTMAAAAA ATPGLGPLQL QQFYAAQLAA 
MQVSPGGKLL GLPQGNLGAA VSPTSIHTDK STNSPPPKSK VPSSIS

Genular Protein ID: 1474645621

Symbol: B2KFM9_MOUSE

Name: N/A

UniProtKB Accession Codes:

B2KFM9

Database IDs:

AGR 1 ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 GeneTree 1 InterPro 2 MGI 2 MaxQB 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 jPOST 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 763
  • Mass: 84074
  • Checksum: AABF1985D86532B5
  • Sequence:
    • MLTDPDLPQE FERMSSKRPA SPYGETDGEV AMVTSRQKVE EEESERLPAF HLPLHVSFPN 
KPHSEEFQPV SLLTQETCGP RTPTVQHNTM EVDGNKVMSS LAPYNSSTSP QKAEEGGRQS 
GESVSSAALG TPERRKGSLA DVVDTLKQRK MEELIKNEPE DTPSIEKLLS KDWKDKLLAM 
GSGNFGEIKG TPESLAEKER QLMGMINQLT SLREQLLAAH DEQKKLAASQ IEKQRQQMEL 
AKQQQEQIAR QQQQLLQQQH KINLLQQQIQ VQGQLPPLMI PVFPPDQRTL AAAAQQGFLL 
PPGFSYKAGC SDPYPVQLIP TTMAAAAAAT PGLGPLQLQQ FYAAQLAAMQ VSPGGKLLGL 
PQGNLGAAVS PTSIHTDKST NSPPPKSKDE VAQPLNLSAK PKTSDGKSPA SPTSPHMPAL 
RINSGAGPLK ASVPAALASP SARVSTIGYL NDHDAVTKAI QEARQMKEQL RREQQALDGK 
VAVVNSIGLS NCRTEKEKTT LESLTQQLAV KQNEEGKFSH GMMDFNMSGD SDGSAGVSES 
RIYRESRGRG SNEPHIKRPM NAFMVWAKDE RRKILQAFPD MHNSNISKIL GSRWKAMTNL 
EKQPYYEEQA RLSKQHLEKY PDYKYKPRPK RTCLVDGKKL RIGEYKAIMR NRRQEMRQYF 
NVGQQAQIPI ATAGVVYPSA IAMAGMPSPH LPSEHSSVSS SPEPGMPVIQ STYGAKGEEP 
HIKEEIQAED INGEIYEEYD EEEEDPDVDY GSDSENHIAG QAN

Genular Protein ID: 3812848556

Symbol: Q2TBA9_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q2TBA9

Database IDs:

AGR 1 ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 IntAct 1 InterPro 2 KEGG 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 3 SAM 2 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 715
  • Mass: 79257
  • Checksum: C605C0682D018EC1
  • Sequence:
    • MLTDPDLPQE FERMSSKRPA SPYGETDGEV AMVTSRQKVE EEESERLPAF HLPLHVSFPN 
KPHSEEFQPV SLLTQETCGP RTPTVQHNTM EVDGNKVMSS LAPYNSSTSP QKAEEGGRQS 
GESVSSAALG TPERRKGSLA DVVDTLKQRK MEELIKNEPE DTPSIEKLLS KDWKDKLLAM 
GSGNFGEIKG TPESLAEKER QLMGMINQLT SLREQLLAAH DEQKKLAASQ IEKQRQQMEL 
AKQQQEQIAR QQQQLLQQQH KINLLQQQIQ QVQGQLPPLM IPVFPPDQRT LAAAAQQGFL 
LPPGFSYKAG CSDPYPVQLI PTTMAAAAAA TPGLGPLQLQ DEVAQPLNLS AKPKTSDGKS 
PASPTSPHMP ALRINSGAGP LKASVPAALA SPSARVSTIG YLNDHDAVTK AIQEARQMKE 
QLRREQQALD GKVAVVNSIG LSNCRTEKEK TTLESLTQQL AVKQNEEGKF SHGMMDFNMS 
GDSDGSAGVS ESRIYRESRG RGSNEPHIKR PMNAFMVWAK DERRKILQAF PDMHNSNISK 
ILGSRWKAMT NLEKQPYYEE QARLSKQHLE KYPDYKYKPR PKRTCLVDGK KLRIGEYKAI 
MRNRRQEMRQ YFNVGQQAQI PIATAGVVYP SAIAMAGMPS PHLPSEHSSV SSSPEPGMPV 
IQSTYGAKGE EPHIKEEIQA EDINGEIYEE YDEEEEDPDV DYGSDSENHI AGQAN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.