Genular: Defining Cellular Identity and Function

Details for: Sox9

Gene ID: 20682

Symbol: Sox9

Ensembl ID: ENSMUSG00000000567

Description: SRY (sex determining region Y)-box 9

Associated with

Deactivation of the beta-catenin transactivating complex
(R-MMU-3769402)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by wnt
(R-MMU-195721)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Transcriptional regulation by runx2
(R-MMU-8878166)
Aortic valve morphogenesis
(GO:0003180)
Apoptotic process
(GO:0006915)
Beta-catenin binding
(GO:0008013)
Bhlh transcription factor binding
(GO:0043425)
Branching involved in ureteric bud morphogenesis
(GO:0001658)
Camp-mediated signaling
(GO:0019933)
Cartilage condensation
(GO:0001502)
Cell differentiation
(GO:0030154)
Cell population proliferation
(GO:0008283)
Central nervous system development
(GO:0007417)
Chondrocyte development
(GO:0002063)
Chondrocyte differentiation
(GO:0002062)
Chondrocyte differentiation involved in endochondral bone morphogenesis
(GO:0003413)
Chondrocyte hypertrophy
(GO:0003415)
Chromatin binding
(GO:0003682)
Chromatin remodeling
(GO:0006338)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Cytoskeleton organization
(GO:0007010)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Endocardial cushion morphogenesis
(GO:0003203)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Epithelial to mesenchymal transition
(GO:0001837)
Gene expression
(GO:0010467)
Glandular epithelial cell differentiation
(GO:0002067)
Glial cell fate specification
(GO:0021780)
Growth plate cartilage chondrocyte growth
(GO:0003430)
Hair follicle development
(GO:0001942)
Heart development
(GO:0007507)
Heart valve development
(GO:0003170)
Heart valve formation
(GO:0003188)
Heart valve morphogenesis
(GO:0003179)
Male germ-line sex determination
(GO:0019100)
Male gonad development
(GO:0008584)
Mesenchymal cell proliferation
(GO:0010463)
Morphogenesis of an epithelium
(GO:0002009)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of immune system process
(GO:0002683)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neural crest cell development
(GO:0014032)
Notch signaling pathway
(GO:0007219)
Nucleosome assembly
(GO:0006334)
Ossification
(GO:0001503)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of epithelial cell migration
(GO:0010634)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of mesenchymal cell proliferation
(GO:0002053)
Positive regulation of protein phosphorylation
(GO:0001934)
Pre-mrna intronic binding
(GO:0097157)
Protein binding
(GO:0005515)
Protein kinase a catalytic subunit binding
(GO:0034236)
Protein phosphorylation
(GO:0006468)
Regulation of cell adhesion
(GO:0030155)
Regulation of cell cycle process
(GO:0010564)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gene expression
(GO:0010468)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Signal transduction
(GO:0007165)
Skeletal system development
(GO:0001501)
Spermatogenesis
(GO:0007283)
Tissue homeostasis
(GO:0001894)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)

Other Information

Proteins

SOX9_MOUSE

Genular Protein ID: 650803577

Symbol: SOX9_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q04887 Q8C7L2 Q91ZK2 Q99KQ0

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8441686

Title: Seven new members of the Sox gene family expressed during mouse development.

PubMed ID: 8441686

DOI: 10.1093/nar/21.3.744

PubMed ID: 7704017

Title: The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos.

PubMed ID: 7704017

DOI: 10.1038/ng0195-15

PubMed ID: 9119111

Title: SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse.

PubMed ID: 9119111

DOI: 10.1006/dbio.1996.8487

PubMed ID: 10319868

Title: Sox9 is required for cartilage formation.

PubMed ID: 10319868

DOI: 10.1038/8792

PubMed ID: 10805756

Title: Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer.

PubMed ID: 10805756

DOI: 10.1128/mcb.20.11.4149-4158.2000

PubMed ID: 11120880

Title: The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bones.

PubMed ID: 11120880

DOI: 10.1073/pnas.98.1.160

PubMed ID: 11371614

Title: Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization.

PubMed ID: 11371614

DOI: 10.1073/pnas.111092198

PubMed ID: 11857796

Title: Conditional inactivation of Sox9: a mouse model for campomelic dysplasia.

PubMed ID: 11857796

DOI: 10.1002/gene.10050

PubMed ID: 12414734

Title: The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6.

PubMed ID: 12414734

DOI: 10.1101/gad.1017802

PubMed ID: 15529345

Title: The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage.

PubMed ID: 15529345

DOI: 10.1002/art.20611

PubMed ID: 15132997

Title: Interactions between Sox9 and beta-catenin control chondrocyte differentiation.

PubMed ID: 15132997

DOI: 10.1101/gad.1171104

PubMed ID: 15694126

Title: The transcription factor Sox9 is degraded by the ubiquitin-proteasome system and stabilized by a mutation in a ubiquitin-target site.

PubMed ID: 15694126

DOI: 10.1016/j.matbio.2004.10.002

PubMed ID: 16203988

Title: Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors.

PubMed ID: 16203988

DOI: 10.1073/pnas.0504750102

PubMed ID: 17525254

Title: SRY-related HMG box 9 regulates the expression of Col4a2 through transactivating its enhancer element in mesangial cells.

PubMed ID: 17525254

DOI: 10.2353/ajpath.2007.060899

PubMed ID: 18415932

Title: Loss of Sox9 function results in defective chondrocyte differentiation of mouse embryonic stem cells in vitro.

PubMed ID: 18415932

DOI: 10.1387/ijdb.072490gh

PubMed ID: 20940257

Title: The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9.

PubMed ID: 20940257

DOI: 10.1242/jcs.071373

PubMed ID: 21367821

Title: Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways.

PubMed ID: 21367821

DOI: 10.1242/dev.057802

PubMed ID: 21212101

Title: SOX9 controls epithelial branching by activating RET effector genes during kidney development.

PubMed ID: 21212101

DOI: 10.1093/hmg/ddq558

PubMed ID: 22421045

Title: Sox9 directs hypertrophic maturation and blocks osteoblast differentiation of growth plate chondrocytes.

PubMed ID: 22421045

DOI: 10.1016/j.devcel.2011.12.024

PubMed ID: 22510880

Title: Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation.

PubMed ID: 22510880

DOI: 10.1038/emboj.2012.91

PubMed ID: 24191021

Title: Sox9 plays multiple roles in the lung epithelium during branching morphogenesis.

PubMed ID: 24191021

DOI: 10.1073/pnas.1311847110

PubMed ID: 25229425

Title: SOX9 regulates multiple genes in chondrocytes, including genes encoding ECM proteins, ECM modification enzymes, receptors, and transporters.

PubMed ID: 25229425

DOI: 10.1371/journal.pone.0107577

PubMed ID: 26146088

Title: Distinct transcriptional programs underlie Sox9 regulation of the mammalian chondrocyte.

PubMed ID: 26146088

DOI: 10.1016/j.celrep.2015.06.013

PubMed ID: 26150426

Title: The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis.

PubMed ID: 26150426

DOI: 10.1093/nar/gkv688

PubMed ID: 26910618

Title: Acetylation reduces SOX9 nuclear entry and ACAN gene transactivation in human chondrocytes.

PubMed ID: 26910618

DOI: 10.1111/acel.12456

PubMed ID: 28263186

Title: Loss of DDRGK1 modulates SOX9 ubiquitination in spondyloepimetaphyseal dysplasia.

PubMed ID: 28263186

DOI: 10.1172/jci90193

PubMed ID: 29644115

Title: SHP2 regulates skeletal cell fate by modifying SOX9 expression and transcriptional activity.

PubMed ID: 29644115

DOI: 10.1038/s41413-018-0013-z

PubMed ID: 30021842

Title: SOX9 is dispensable for the initiation of epigenetic remodeling and the activation of marker genes at the onset of chondrogenesis.

PubMed ID: 30021842

DOI: 10.1242/dev.164459

PubMed ID: 29659575

Title: Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions.

PubMed ID: 29659575

DOI: 10.1371/journal.pgen.1007346

PubMed ID: 31121357

Title: Persistent Sox9 expression in hypertrophic chondrocytes suppresses transdifferentiation into osteoblasts.

PubMed ID: 31121357

DOI: 10.1016/j.bone.2019.05.027

PubMed ID: 31382142

Title: SOX9 in cartilage development and disease.

PubMed ID: 31382142

DOI: 10.1016/j.ceb.2019.07.008

PubMed ID: 32103177

Title: Lipid availability determines fate of skeletal progenitor cells via SOX9.

PubMed ID: 32103177

DOI: 10.1038/s41586-020-2050-1

PubMed ID: 26527273

Title: Crystallization and X-ray diffraction analysis of the HMG domain of the chondrogenesis master regulator Sox9 in complex with a ChIP-Seq-identified DNA element.

PubMed ID: 26527273

DOI: 10.1107/s2053230x1501969x

Sequence Information:

Length: 507
Mass: 56077
Checksum: 01FC3B54FF329BDA
Sequence:

MNLLDPFMKM TDEQEKGLSG APSPTMSEDS AGSPCPSGSG SDTENTRPQE NTFPKGEPDL 
KKESEEDKFP VCIREAVSQV LKGYDWTLVP MPVRVNGSSK NKPHVKRPMN AFMVWAQAAR 
RKLADQYPHL HNAELSKTLG KLWRLLNESE KRPFVEEAER LRVQHKKDHP DYKYQPRRRK 
SVKNGQAEAE EATEQTHISP NAIFKALQAD SPHSSSGMSE VHSPGEHSGQ SQGPPTPPTT 
PKTDVQAGKV DLKREGRPLA EGGRQPPIDF RDVDIGELSS DVISNIETFD VNEFDQYLPP 
NGHPGVPATH GQVTYTGSYG ISSTAPTPAT AGHVWMSKQQ APPPPPQQPP QAPQAPQAPP 
QQQAPPQQPQ APQQQQAHTL TTLSSEPGQS QRTHIKTEQL SPSHYSEQQQ HSPQQISYSP 
FNLPHYSPSY PPITRSQYDY ADHQNSGSYY SHAAGQGSGL YSTFTYMNPA QRPMYTPIAD 
TSGVPSIPQT HSPQHWEQPV YTQLTRP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Sox9

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Seven new members of the Sox gene family expressed during mouse development. PubMed ID: 8441686

The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos. PubMed ID: 7704017

SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse. PubMed ID: 9119111

Sox9 is required for cartilage formation. PubMed ID: 10319868

Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer. PubMed ID: 10805756

The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bones. PubMed ID: 11120880

Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization. PubMed ID: 11371614

Conditional inactivation of Sox9: a mouse model for campomelic dysplasia. PubMed ID: 11857796

The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. PubMed ID: 12414734

The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage. PubMed ID: 15529345

Interactions between Sox9 and beta-catenin control chondrocyte differentiation. PubMed ID: 15132997

The transcription factor Sox9 is degraded by the ubiquitin-proteasome system and stabilized by a mutation in a ubiquitin-target site. PubMed ID: 15694126

Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors. PubMed ID: 16203988

SRY-related HMG box 9 regulates the expression of Col4a2 through transactivating its enhancer element in mesangial cells. PubMed ID: 17525254

Loss of Sox9 function results in defective chondrocyte differentiation of mouse embryonic stem cells in vitro. PubMed ID: 18415932

The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9. PubMed ID: 20940257

Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. PubMed ID: 21367821

SOX9 controls epithelial branching by activating RET effector genes during kidney development. PubMed ID: 21212101

Sox9 directs hypertrophic maturation and blocks osteoblast differentiation of growth plate chondrocytes. PubMed ID: 22421045

Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation. PubMed ID: 22510880

Sox9 plays multiple roles in the lung epithelium during branching morphogenesis. PubMed ID: 24191021

SOX9 regulates multiple genes in chondrocytes, including genes encoding ECM proteins, ECM modification enzymes, receptors, and transporters. PubMed ID: 25229425

Distinct transcriptional programs underlie Sox9 regulation of the mammalian chondrocyte. PubMed ID: 26146088

The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis. PubMed ID: 26150426

Acetylation reduces SOX9 nuclear entry and ACAN gene transactivation in human chondrocytes. PubMed ID: 26910618

Loss of DDRGK1 modulates SOX9 ubiquitination in spondyloepimetaphyseal dysplasia. PubMed ID: 28263186

SHP2 regulates skeletal cell fate by modifying SOX9 expression and transcriptional activity. PubMed ID: 29644115

SOX9 is dispensable for the initiation of epigenetic remodeling and the activation of marker genes at the onset of chondrogenesis. PubMed ID: 30021842

Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions. PubMed ID: 29659575

Persistent Sox9 expression in hypertrophic chondrocytes suppresses transdifferentiation into osteoblasts. PubMed ID: 31121357

SOX9 in cartilage development and disease. PubMed ID: 31382142

Lipid availability determines fate of skeletal progenitor cells via SOX9. PubMed ID: 32103177

Crystallization and X-ray diffraction analysis of the HMG domain of the chondrogenesis master regulator Sox9 in complex with a ChIP-Seq-identified DNA element. PubMed ID: 26527273