Genular: Defining Cellular Identity and Function

Details for: Sphk1

Gene ID: 20698

Symbol: Sphk1

Ensembl ID: ENSMUSG00000061878

Description: sphingosine kinase 1

Associated with

Antiviral mechanism by ifn-stimulated genes
(R-MMU-1169410)
Association of tric/cct with target proteins during biosynthesis
(R-MMU-390471)
Chaperonin-mediated protein folding
(R-MMU-390466)
Cytokine signaling in immune system
(R-MMU-1280215)
Esr-mediated signaling
(R-MMU-8939211)
Extra-nuclear estrogen signaling
(R-MMU-9009391)
Immune system
(R-MMU-168256)
Interferon signaling
(R-MMU-913531)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Metabolism of proteins
(R-MMU-392499)
Pkr-mediated signaling
(R-MMU-9833482)
Protein folding
(R-MMU-391251)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by vegf
(R-MMU-194138)
Signal transduction
(R-MMU-162582)
Sphingolipid de novo biosynthesis
(R-MMU-1660661)
Sphingolipid metabolism
(R-MMU-428157)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
Vegfr2 mediated cell proliferation
(R-MMU-5218921)
Acetyltransferase activity
(GO:0016407)
Atp binding
(GO:0005524)
Axon
(GO:0030424)
Blood vessel development
(GO:0001568)
Brain development
(GO:0007420)
Calcium-mediated signaling
(GO:0019722)
Calmodulin binding
(GO:0005516)
Cell population proliferation
(GO:0008283)
Cellular response to growth factor stimulus
(GO:0071363)
Cellular response to hydrogen peroxide
(GO:0070301)
Cellular response to vascular endothelial growth factor stimulus
(GO:0035924)
Clathrin-coated pit
(GO:0005905)
Cyclooxygenase pathway
(GO:0019371)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
D-erythro-sphingosine kinase activity
(GO:0017050)
Dna binding
(GO:0003677)
Dna biosynthetic process
(GO:0071897)
Early endosome membrane
(GO:0031901)
Endocytic vesicle
(GO:0030139)
Endosome
(GO:0005768)
Inflammatory response
(GO:0006954)
Intracellular membrane-bounded organelle
(GO:0043231)
Kinase activity
(GO:0016301)
Lipid binding
(GO:0008289)
Lipid metabolic process
(GO:0006629)
Magnesium ion binding
(GO:0000287)
Membrane
(GO:0016020)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of ceramide biosynthetic process
(GO:1900060)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of interleukin-17 production
(GO:0032740)
Positive regulation of mitotic cell cycle
(GO:0045931)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of neurotransmitter secretion
(GO:0001956)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of non-canonical nf-kappab signal transduction
(GO:1901224)
Positive regulation of p38mapk cascade
(GO:1900745)
Positive regulation of peptidyl-threonine phosphorylation
(GO:0010800)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of protein ubiquitination
(GO:0031398)
Positive regulation of smooth muscle contraction
(GO:0045987)
Protein acetylation
(GO:0006473)
Protein phosphatase 2a binding
(GO:0051721)
Regulation of endocytosis
(GO:0030100)
Regulation of endosomal vesicle fusion
(GO:1905364)
Regulation of interleukin-1 beta production
(GO:0032651)
Regulation of microglial cell activation
(GO:1903978)
Regulation of neuroinflammatory response
(GO:0150077)
Regulation of phagocytosis
(GO:0050764)
Regulation of tumor necrosis factor-mediated signaling pathway
(GO:0010803)
Response to tumor necrosis factor
(GO:0034612)
Sphinganine kinase activity
(GO:0008481)
Sphingolipid mediated signaling pathway
(GO:0090520)
Sphingosine-1-phosphate receptor activity
(GO:0038036)
Sphingosine biosynthetic process
(GO:0046512)
Sphingosine metabolic process
(GO:0006670)
Synapse
(GO:0045202)
Synaptic vesicle
(GO:0008021)
Transferase activity
(GO:0016740)

Other Information

Proteins

SPHK1_MOUSE

Genular Protein ID: 606412423

Symbol: SPHK1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8CI15 O88886 Q3U2E3 Q91ZN3

Database IDs:

Citations:

PubMed ID: 9726979

Title: Molecular cloning and functional characterization of murine sphingosine kinase.

PubMed ID: 9726979

DOI: 10.1074/jbc.273.37.23722

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15196915

Title: Aminoacylase 1 is a sphingosine kinase 1-interacting protein.

PubMed ID: 15196915

DOI: 10.1016/j.febslet.2004.04.093

PubMed ID: 15459201

Title: Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720.

PubMed ID: 15459201

DOI: 10.1074/jbc.m406512200

PubMed ID: 16118219

Title: SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism.

PubMed ID: 16118219

DOI: 10.1074/jbc.m502207200

PubMed ID: 16314531

Title: Essential role for sphingosine kinases in neural and vascular development.

PubMed ID: 16314531

DOI: 10.1128/mcb.25.24.11113-11121.2005

PubMed ID: 17346996

Title: The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis.

PubMed ID: 17346996

DOI: 10.1016/j.immuni.2007.02.008

PubMed ID: 21084291

Title: The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720.

PubMed ID: 21084291

DOI: 10.1074/jbc.m110.171116

PubMed ID: 24929359

Title: Coupling between endocytosis and sphingosine kinase 1 recruitment.

PubMed ID: 24929359

DOI: 10.1038/ncb2987

PubMed ID: 25417698

Title: Pathological roles of the VEGF/SphK pathway in Niemann-Pick type C neurons.

PubMed ID: 25417698

DOI: 10.1038/ncomms6514

PubMed ID: 27806293

Title: Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking.

PubMed ID: 27806293

DOI: 10.1016/j.celrep.2016.10.019

PubMed ID: 28049734

Title: Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking.

PubMed ID: 28049734

DOI: 10.1074/jbc.m116.762377

PubMed ID: 29662056

Title: Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.

PubMed ID: 29662056

DOI: 10.1038/s41467-018-03674-2

PubMed ID: 33334894

Title: Erythrocytes efficiently utilize exogenous sphingosines for S1P synthesis and export via Mfsd2b.

PubMed ID: 33334894

DOI: 10.1074/jbc.ra120.012941

Sequence Information:

Length: 382
Mass: 42443
Checksum: B791FAA58FCE3D29
Sequence:

MEPVECPRGL LPRPCRVLVL LNPQGGKGKA LQLFQSRVQP FLEEAEITFK LILTERKNHA 
RELVCAEELG HWDALAVMSG DGLMHEVVNG LMERPDWETA IQKPLCSLPG GSGNALAASV 
NHYAGYEQVT NEDLLINCTL LLCRRRLSPM NLLSLHTASG LRLYSVLSLS WGFVADVDLE 
SEKYRRLGEI RFTVGTFFRL ASLRIYQGQL AYLPVGTVAS KRPASTLVQK GPVDTHLVPL 
EEPVPSHWTV VPEQDFVLVL VLLHTHLSSE LFAAPMGRCE AGVMHLFYVR AGVSRAALLR 
LFLAMQKGKH MELDCPYLVH VPVVAFRLEP RSQRGVFSVD GELMVCEAVQ GQVHPNYLWM 
VCGSRDAPSG RDSRRGPPPE EP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Sphk1

Associated with

Other Information

Molecular cloning and functional characterization of murine sphingosine kinase. PubMed ID: 9726979

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Aminoacylase 1 is a sphingosine kinase 1-interacting protein. PubMed ID: 15196915

Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. PubMed ID: 15459201

SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism. PubMed ID: 16118219

Essential role for sphingosine kinases in neural and vascular development. PubMed ID: 16314531

The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis. PubMed ID: 17346996

The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720. PubMed ID: 21084291

Coupling between endocytosis and sphingosine kinase 1 recruitment. PubMed ID: 24929359

Pathological roles of the VEGF/SphK pathway in Niemann-Pick type C neurons. PubMed ID: 25417698

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking. PubMed ID: 27806293

Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking. PubMed ID: 28049734

Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease. PubMed ID: 29662056

Erythrocytes efficiently utilize exogenous sphingosines for S1P synthesis and export via Mfsd2b. PubMed ID: 33334894