Genular: Defining Cellular Identity and Function

Details for: Serpina1a

Gene ID: 20700

Symbol: Serpina1a

Ensembl ID: ENSMUSG00000066366

Description: serine (or cysteine) peptidase inhibitor, clade A, member 1A

Associated with

Acute-phase response
(GO:0006953)
Collagen-containing extracellular matrix
(GO:0062023)
Endopeptidase inhibitor activity
(GO:0004866)
Endoplasmic reticulum
(GO:0005783)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Golgi apparatus
(GO:0005794)
Identical protein binding
(GO:0042802)
Intracellular membrane-bounded organelle
(GO:0043231)
Negative regulation of endopeptidase activity
(GO:0010951)
Negative regulation of peptidase activity
(GO:0010466)
Peptidase inhibitor activity
(GO:0030414)
Protease binding
(GO:0002020)
Protein binding
(GO:0005515)
Protein n-linked glycosylation
(GO:0006487)
Response to chromate
(GO:0046687)
Response to cytokine
(GO:0034097)
Response to lead ion
(GO:0010288)
Response to methanol
(GO:0033986)
Response to peptide hormone
(GO:0043434)
Serine-type endopeptidase inhibitor activity
(GO:0004867)

Other Information

Proteins

Alpha-1-antitrypsin 1-1
A0A0A0MQA3_MOUSE

Genular Protein ID: 2429285062

Symbol: A1AT1_MOUSE

Name: Alpha-1-antitrypsin 1-1

UniProtKB Accession Codes:

P07758 Q3UJ47 Q80YB8 Q8JZV6 Q91XB8

Database IDs:

Citations:

PubMed ID: 1946354

Title: Multiple murine alpha 1-protease inhibitor genes show unusual evolutionary divergence.

PubMed ID: 1946354

DOI: 10.1073/pnas.88.21.9417

PubMed ID: 12408969

Title: The murine alpha(1)-proteinase inhibitor gene family: polymorphism, chromosomal location, and structure.

PubMed ID: 12408969

DOI: 10.1016/s0888-7543(02)96864-3

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3007061

Title: Isolation and characterization of the alpha 1-antitrypsin gene of mice.

PubMed ID: 3007061

DOI: 10.1089/dna.1986.5.29

PubMed ID: 8619829

Title: The expression and characterization of five recombinant murine alpha 1-protease inhibitor proteins.

PubMed ID: 8619829

DOI: 10.1006/bbrc.1996.0182

PubMed ID: 11961105

Title: Functional diversification during evolution of the murine alpha(1)-proteinase inhibitor family: role of the hypervariable reactive center loop.

PubMed ID: 11961105

DOI: 10.1093/oxfordjournals.molbev.a004130

PubMed ID: 12659817

Title: A review and comparison of the murine alpha1-antitrypsin and alpha1-antichymotrypsin multigene clusters with the human clade A serpins.

PubMed ID: 12659817

DOI: 10.1016/s0888-7543(02)00041-1

PubMed ID: 17330941

Title: Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides.

PubMed ID: 17330941

DOI: 10.1021/pr0604559

Sequence Information:

Length: 413
Mass: 46003
Checksum: 1124B2CC356232F4
Sequence:

MTPSISWGLL LLAGLCCLVP SFLAEDVQET DTSQKDQSPA SHEIATNLGD FAISLYRELV 
HQSNTSNIFF SPVSIATAFA MLSLGSKGDT HTQILEGLQF NLTQTSEADI HKSFQHLLQT 
LNRPDSELQL STGNGLFVNN DLKLVEKFLE EAKNHYQAEV FSVNFAESEE AKKVINDFVE 
KGTQGKIAEA VKKLDQDTVF ALANYILFKG KWKKPFDPEN TEEAEFHVDE STTVKVPMMT 
LSGMLHVHHC STLSSWVLLM DYAGNATAVF LLPDDGKMQH LEQTLSKELI SKFLLNRRRR 
LAQIHFPRLS ISGEYNLKTL MSPLGITRIF NNGADLSGIT EENAPLKLSQ AVHKAVLTID 
ETGTEAAAVT VLQMVPMSMP PILRFDHPFL FIIFEEHTQS PIFLGKVVDP THK

Genular Protein ID: 4060410216

Symbol: A0A0A0MQA3_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A0A0MQA3

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 436
Mass: 48796
Checksum: A96D13F1BC4F730B
Sequence:

MYCAIRVRLS RLFTVKGQKA RWKMTPSISW GLLLLAGLCC LVPSFLAEDV QETDTSQKDQ 
SPASHEIATN LGDFAISLYR ELVHQSNTSN IFFSPVSIAT AFAMLSLGSK GDTHTQILEG 
LQFNLTQTSE ADIHKSFQHL LQTLNRPDSE LQLSTGNGLF VNNDLKLVEK FLEEAKNHYQ 
AEVFSVNFAE SEEAKKVIND FVEKGTQGKI AEAVKKLDQD TVFALANYIL FKGKWKKPFD 
PENTEEAEFH VDESTTVKVP MMTLSGMLHV HHCSTLSSWV LLMDYAGNAT AVFLLPDDGK 
MQHLEQTLSK ELISKFLLNR RRRLAQIHFP RLSISGEYNL KTLMSPLGIT RIFNNGADLS 
GITEENAPLK LSQAVHKAVL TIDETGTEAA AVTVLQMVPM SMPPILRFDH PFLFIIFEEH 
TQSPIFLGKV VDPTHK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Serpina1a

Associated with

Other Information

Multiple murine alpha 1-protease inhibitor genes show unusual evolutionary divergence. PubMed ID: 1946354

The murine alpha(1)-proteinase inhibitor gene family: polymorphism, chromosomal location, and structure. PubMed ID: 12408969

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Isolation and characterization of the alpha 1-antitrypsin gene of mice. PubMed ID: 3007061

The expression and characterization of five recombinant murine alpha 1-protease inhibitor proteins. PubMed ID: 8619829

Functional diversification during evolution of the murine alpha(1)-proteinase inhibitor family: role of the hypervariable reactive center loop. PubMed ID: 11961105

A review and comparison of the murine alpha1-antitrypsin and alpha1-antichymotrypsin multigene clusters with the human clade A serpins. PubMed ID: 12659817

Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides. PubMed ID: 17330941

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303