Genular: Defining Cellular Identity and Function

Details for: Serpina1b

Gene ID: 20701

Symbol: Serpina1b

Ensembl ID: ENSMUSG00000071178

Description: serine (or cysteine) preptidase inhibitor, clade A, member 1B

Associated with

Asparagine n-linked glycosylation
(R-MMU-446203)
Cargo concentration in the er
(R-MMU-5694530)
Copii-mediated vesicle transport
(R-MMU-204005)
Er to golgi anterograde transport
(R-MMU-199977)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Membrane trafficking
(R-MMU-199991)
Metabolism of proteins
(R-MMU-392499)
Neutrophil degranulation
(R-MMU-6798695)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet degranulation
(R-MMU-114608)
Post-translational protein modification
(R-MMU-597592)
Post-translational protein phosphorylation
(R-MMU-8957275)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-MMU-381426)
Response to elevated platelet cytosolic ca2+
(R-MMU-76005)
Transport to the golgi and subsequent modification
(R-MMU-948021)
Vesicle-mediated transport
(R-MMU-5653656)
Acute-phase response
(GO:0006953)
Endopeptidase inhibitor activity
(GO:0004866)
Endoplasmic reticulum
(GO:0005783)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Golgi apparatus
(GO:0005794)
Identical protein binding
(GO:0042802)
Intracellular membrane-bounded organelle
(GO:0043231)
In utero embryonic development
(GO:0001701)
Negative regulation of endopeptidase activity
(GO:0010951)
Negative regulation of peptidase activity
(GO:0010466)
Peptidase inhibitor activity
(GO:0030414)
Protease binding
(GO:0002020)
Protein binding
(GO:0005515)
Protein n-linked glycosylation
(GO:0006487)
Response to chromate
(GO:0046687)
Response to cytokine
(GO:0034097)
Response to lead ion
(GO:0010288)
Response to methanol
(GO:0033986)
Response to peptide hormone
(GO:0043434)
Serine-type endopeptidase inhibitor activity
(GO:0004867)

Other Information

Proteins

Alpha-1-antitrypsin 1-2

Genular Protein ID: 61541183

Symbol: A1AT2_MOUSE

Name: Alpha-1-antitrypsin 1-2

UniProtKB Accession Codes:

P22599 Q61283 Q80ZH5 Q8VC20

Database IDs:

Citations:

PubMed ID: 2303252

Title: Complete cDNA sequence and chromosomal localization of mouse alpha 1-antitrypsin.

PubMed ID: 2303252

DOI: 10.1016/0888-7543(90)90453-2

PubMed ID: 12408969

Title: The murine alpha(1)-proteinase inhibitor gene family: polymorphism, chromosomal location, and structure.

PubMed ID: 12408969

DOI: 10.1016/s0888-7543(02)96864-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1946354

Title: Multiple murine alpha 1-protease inhibitor genes show unusual evolutionary divergence.

PubMed ID: 1946354

DOI: 10.1073/pnas.88.21.9417

PubMed ID: 8619829

Title: The expression and characterization of five recombinant murine alpha 1-protease inhibitor proteins.

PubMed ID: 8619829

DOI: 10.1006/bbrc.1996.0182

PubMed ID: 11961105

Title: Functional diversification during evolution of the murine alpha(1)-proteinase inhibitor family: role of the hypervariable reactive center loop.

PubMed ID: 11961105

DOI: 10.1093/oxfordjournals.molbev.a004130

PubMed ID: 12659817

Title: A review and comparison of the murine alpha1-antitrypsin and alpha1-antichymotrypsin multigene clusters with the human clade A serpins.

PubMed ID: 12659817

DOI: 10.1016/s0888-7543(02)00041-1

PubMed ID: 16944957

Title: Proteome-wide characterization of N-glycosylation events by diagonal chromatography.

PubMed ID: 16944957

DOI: 10.1021/pr060186m

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 413
Mass: 45975
Checksum: 92BD12B6D4768D7B
Sequence:

MTPSISWGLL LLAGLCCMVP SFLAEDVQET DTSQKDQSPA SHEIATNLGD FAISLYRELV 
HQSNTSNIFF SPVSIATAFA MLSLGSKGDT HTQILEGLQF NLTQTSEADI HKSFQHLLQT 
LNRPDSELQL STGNGLFVNN DLKLVEKFLE EAKNHYQAEV FSVNFAESEE AKKVINDFVE 
KGTQGKIVEA VKELDQDTVF ALANYILFKG KWKKPFDPEN TEEAEFHVDK STTVKVPMMM 
LSGMLDVHHC SILSSWVLLM DYAGNASAVF LLPEDGKMQH LEQTLNKELI SKILLNRRRR 
LVQIHIPRLS ISGDYNLKTL MSPLGITRIF NNGADLSGIT EENAPLKLSK AVHKAVLTID 
ETGTEAAAAT VFEAVPMSMP PILRFDHPFL FIIFEEHTQS PIFVGKVVDP THK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Serpina1b

Associated with

Other Information

Complete cDNA sequence and chromosomal localization of mouse alpha 1-antitrypsin. PubMed ID: 2303252

The murine alpha(1)-proteinase inhibitor gene family: polymorphism, chromosomal location, and structure. PubMed ID: 12408969

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Multiple murine alpha 1-protease inhibitor genes show unusual evolutionary divergence. PubMed ID: 1946354

The expression and characterization of five recombinant murine alpha 1-protease inhibitor proteins. PubMed ID: 8619829

Functional diversification during evolution of the murine alpha(1)-proteinase inhibitor family: role of the hypervariable reactive center loop. PubMed ID: 11961105

A review and comparison of the murine alpha1-antitrypsin and alpha1-antichymotrypsin multigene clusters with the human clade A serpins. PubMed ID: 12659817

Proteome-wide characterization of N-glycosylation events by diagonal chromatography. PubMed ID: 16944957

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079