Genular: Defining Cellular Identity and Function

Details for: Serpina1c

Gene ID: 20702

Symbol: Serpina1c

Ensembl ID: ENSMUSG00000079015

Description: serine (or cysteine) peptidase inhibitor, clade A, member 1C

Associated with

Asparagine n-linked glycosylation
(R-MMU-446203)
Cargo concentration in the er
(R-MMU-5694530)
Copii-mediated vesicle transport
(R-MMU-204005)
Er to golgi anterograde transport
(R-MMU-199977)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Membrane trafficking
(R-MMU-199991)
Metabolism of proteins
(R-MMU-392499)
Neutrophil degranulation
(R-MMU-6798695)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet degranulation
(R-MMU-114608)
Post-translational protein modification
(R-MMU-597592)
Post-translational protein phosphorylation
(R-MMU-8957275)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-MMU-381426)
Response to elevated platelet cytosolic ca2+
(R-MMU-76005)
Transport to the golgi and subsequent modification
(R-MMU-948021)
Vesicle-mediated transport
(R-MMU-5653656)
Endopeptidase inhibitor activity
(GO:0004866)
Endoplasmic reticulum
(GO:0005783)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Golgi apparatus
(GO:0005794)
Identical protein binding
(GO:0042802)
Intracellular membrane-bounded organelle
(GO:0043231)
Negative regulation of endopeptidase activity
(GO:0010951)
Negative regulation of peptidase activity
(GO:0010466)
Peptidase inhibitor activity
(GO:0030414)
Protease binding
(GO:0002020)
Response to chromate
(GO:0046687)
Response to cytokine
(GO:0034097)
Response to lead ion
(GO:0010288)
Response to methanol
(GO:0033986)
Response to peptide hormone
(GO:0043434)
Serine-type endopeptidase inhibitor activity
(GO:0004867)

Other Information

Proteins

Alpha-1-antitrypsin 1-3
A0A0R4J0X5_MOUSE

Genular Protein ID: 4253088855

Symbol: A1AT3_MOUSE

Name: Alpha-1-antitrypsin 1-3

UniProtKB Accession Codes:

Q00896 P81105 Q91V74 Q91WH5 Q91XC1

Database IDs:

Citations:

PubMed ID: 1946354

Title: Multiple murine alpha 1-protease inhibitor genes show unusual evolutionary divergence.

PubMed ID: 1946354

DOI: 10.1073/pnas.88.21.9417

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6547997

Title: Plasma protease inhibitors in mouse and man: divergence within the reactive centre regions.

PubMed ID: 6547997

DOI: 10.1038/311175a0

PubMed ID: 8619829

Title: The expression and characterization of five recombinant murine alpha 1-protease inhibitor proteins.

PubMed ID: 8619829

DOI: 10.1006/bbrc.1996.0182

PubMed ID: 11961105

Title: Functional diversification during evolution of the murine alpha(1)-proteinase inhibitor family: role of the hypervariable reactive center loop.

PubMed ID: 11961105

DOI: 10.1093/oxfordjournals.molbev.a004130

PubMed ID: 12659817

Title: A review and comparison of the murine alpha1-antitrypsin and alpha1-antichymotrypsin multigene clusters with the human clade A serpins.

PubMed ID: 12659817

DOI: 10.1016/s0888-7543(02)00041-1

PubMed ID: 16944957

Title: Proteome-wide characterization of N-glycosylation events by diagonal chromatography.

PubMed ID: 16944957

DOI: 10.1021/pr060186m

Sequence Information:

Length: 412
Mass: 45823
Checksum: FFA3BF10ABC1B8AE
Sequence:

MTPSISWGLL LLAGLCCLVP SFLAEDVQET DTSQKDQSPA SHEIATNLGD FAISLYRELV 
HQSNTSNIFF SPVSIATAFA MLSLGSKGDT HTQILEGLQF NLTQTSEADI HKSFQHLLQT 
LNRPDSELQL STGNGLFVNN DLKLVEKFLE EAKNHYQAEV FSVNFAESEE AKKVINDFVE 
KGTQGKIVEA VKKLDQDTVF ALANYILFKG KWKKPFDPEN TEEAEFHVDE STTVKVPMMT 
LSGMLDVHHC STLSSWVLLM DYAGNATAVF LLPDDGKMQH LEQTLSKELI SKFLLNRRRR 
LAQIHFPRLS ISGEYNLKTL MSPLGITRIF NNGADLSGIT EENAPLKLSQ AVHKAVLTID 
ETGTEAAAVT VLLAVPYSMP PILRFDHPFL FIIFEEHTQS PLFVGKVVDP TH

Genular Protein ID: 3478758695

Symbol: A0A0R4J0X5_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A0R4J0X5

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 413
Mass: 45854
Checksum: 7EAD710919EA1C5B
Sequence:

MTPSISWGLL LLAGLCCLVP SFLAEDVQET DTSQKDQSPA SHEIATNLGD FAISLYRELV 
HQSNTSNIFF SPVSIATAFA MLSLGSKGDT HTQILEGLQF NLTQTSEADI HKSFQHLLQT 
LNRPDSELQL STGNGLFVNN DLKLVEKFLE EAKNHYQAEV FSVNFAESEE AKKVINDFVE 
KGTQGKIAEA VKKLDQDTVF ALANYILFKG KWKKPFDPEN TEEAEFHVDE STTVKVPMMT 
LSGMLDVHHC STLSSWVLLM DYAGNATAVF LLPDDGKMQH LEQTLSKELI SKFLLKRPRR 
LAQIHFPRLS ISGEYNLKTL MSPLGITRIF NNGADLSGIT EENAPLKLSQ AVHKAVLTMD 
ETGTEAAAAT VLLAVPYSMP PIVRFDHPFL FIIFEEHTQS PLFVGKVVDP THK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Serpina1c

Associated with

Other Information

Multiple murine alpha 1-protease inhibitor genes show unusual evolutionary divergence. PubMed ID: 1946354

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Plasma protease inhibitors in mouse and man: divergence within the reactive centre regions. PubMed ID: 6547997

The expression and characterization of five recombinant murine alpha 1-protease inhibitor proteins. PubMed ID: 8619829

Functional diversification during evolution of the murine alpha(1)-proteinase inhibitor family: role of the hypervariable reactive center loop. PubMed ID: 11961105

A review and comparison of the murine alpha1-antitrypsin and alpha1-antichymotrypsin multigene clusters with the human clade A serpins. PubMed ID: 12659817

Proteome-wide characterization of N-glycosylation events by diagonal chromatography. PubMed ID: 16944957

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303