Details for: Spink1

Gene ID: 20730

Symbol: Spink1

Ensembl ID: ENSMUSG00000024503

Description: serine peptidase inhibitor, Kazal type 1

Associated with

  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Negative regulation of calcium ion import
    (GO:0090281)
  • Negative regulation of nitric oxide mediated signal transduction
    (GO:0010751)
  • Negative regulation of peptidase activity
    (GO:0010466)
  • Negative regulation of peptidyl-tyrosine phosphorylation
    (GO:0050732)
  • Negative regulation of serine-type endopeptidase activity
    (GO:1900004)
  • Nitric oxide mediated signal transduction
    (GO:0007263)
  • Peptidase inhibitor activity
    (GO:0030414)
  • Peptidyl-tyrosine phosphorylation
    (GO:0018108)
  • Regulation of acrosome reaction
    (GO:0060046)
  • Regulation of store-operated calcium entry
    (GO:2001256)
  • Serine-type endopeptidase inhibitor activity
    (GO:0004867)
  • Sperm capacitation
    (GO:0048240)

Other Information

Genular Protein ID: 3818620785

Symbol: ISK1_MOUSE

Name: N/A

UniProtKB Accession Codes:

P09036 Q5M9M3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 Ensembl 1 GO 10 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 3 KEGG 1 MEROPS 1 MGI 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 3428272

Title: A secretory protease inhibitor requires androgens for its expression in male sex accessory tissues but is expressed constitutively in pancreas.

PubMed ID: 3428272

DOI: 10.1002/j.1460-2075.1987.tb02705.x

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1929395

Title: Purification and characterization of a trypsin inhibitor from mouse seminal vesicle secretion.

PubMed ID: 1929395

DOI: 10.1016/0003-9861(91)90540-y

PubMed ID: 9828198

Title: Developmental profile of a caltrin-like protease inhibitor, P12, in mouse seminal vesicle and characterization of its binding sites on sperm surface.

PubMed ID: 9828198

DOI: 10.1095/biolreprod59.6.1498

PubMed ID: 14645103

Title: Distinction of sperm-binding site and reactive site for trypsin inhibition on p12 secreted from the accessory sex glands of male mice.

PubMed ID: 14645103

DOI: 10.1095/biolreprod.103.020552

PubMed ID: 16083722

Title: Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice.

PubMed ID: 16083722

DOI: 10.1016/j.gastro.2005.05.057

PubMed ID: 22228629

Title: SPINK3 modulates mouse sperm physiology through the reduction of nitric oxide level independently of its trypsin inhibitory activity.

PubMed ID: 22228629

DOI: 10.1530/rep-11-0107

Sequence Information:

  • Length: 80
  • Mass: 8488
  • Checksum: 4DC1F2EC4804CCA6
  • Sequence:
    • MKVAVIFLLS ALALLSLAGN TFSAKVTGKE ASCHDAVAGC PRIYDPVCGT DGITYANECV 
LCFENRKRIE PVLIRKGGPC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.