Details for: Spop

Gene ID: 20747

Symbol: Spop

Ensembl ID: ENSMUSG00000057522

Description: speckle-type BTB/POZ protein

Associated with

  • Hedgehog 'on' state
    (R-MMU-5632684)
  • Signaling by hedgehog
    (R-MMU-5358351)
  • Signal transduction
    (R-MMU-162582)
  • Cul3-ring ubiquitin ligase complex
    (GO:0031463)
  • Cytoplasm
    (GO:0005737)
  • Glucose homeostasis
    (GO:0042593)
  • Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
    (GO:0070059)
  • Localization
    (GO:0051179)
  • Molecular function inhibitor activity
    (GO:0140678)
  • Negative regulation of dna-binding transcription factor activity
    (GO:0043433)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nuclear speck
    (GO:0016607)
  • Nucleus
    (GO:0005634)
  • Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
    (GO:1902237)
  • Positive regulation of type b pancreatic cell apoptotic process
    (GO:2000676)
  • Proteasome-mediated ubiquitin-dependent protein catabolic process
    (GO:0043161)
  • Protein binding
    (GO:0005515)
  • Protein polyubiquitination
    (GO:0000209)
  • Regulation of proteolysis
    (GO:0030162)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Type b pancreatic cell apoptotic process
    (GO:0097050)
  • Ubiquitin-dependent protein catabolic process
    (GO:0006511)
  • Ubiquitin protein ligase binding
    (GO:0031625)

Other Information

Genular Protein ID: 2502924320

Symbol: SPOP_MOUSE

Name: HIB homolog 1

UniProtKB Accession Codes:

Q6ZWS8 Q3TLC2 Q5ST07 Q76LV9

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 18 Gene3D 2 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 2 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 15121856

Title: Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity.

PubMed ID: 15121856

DOI: 10.1128/mcb.24.10.4372-4383.2004

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12183056

Title: MacroH2A1.2 binds the nuclear protein Spop.

PubMed ID: 12183056

DOI: 10.1016/s0167-4889(02)00249-5

PubMed ID: 16740475

Title: A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.

PubMed ID: 16740475

DOI: 10.1016/j.devcel.2006.05.004

PubMed ID: 20463034

Title: Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors.

PubMed ID: 20463034

DOI: 10.1242/dev.052126

PubMed ID: 20811152

Title: Pcif1 modulates Pdx1 protein stability and pancreatic beta cell function and survival in mice.

PubMed ID: 20811152

DOI: 10.1172/jci40440

Sequence Information:

  • Length: 374
  • Mass: 42132
  • Checksum: EE5F4C5CF6FD09DC
  • Sequence:
    • MSRVPSPPPP AEMSSGPVAE SWCYTQIKVV KFSYMWTINN FSFCREEMGE VIKSSTFSSG 
ANDKLKWCLR VNPKGLDEES KDYLSLYLLL VSCPKSEVRA KFKFSILNAK GEETKAMESQ 
RAYRFVQGKD WGFKKFIRRD FLLDEANGLL PDDKLTLFCE VSVVQDSVNI SGQNTMNMVK 
VPECRLADEL GGLWENSRFT DCCLCVAGQE FQAHKAILAA RSPVFSAMFE HEMEESKKNR 
VEINDVEPEV FKEMMCFIYT GKAPNLDKMA DDLLAAADKY ALERLKVMCE DALCSNLSVE 
NAAEILILAD LHSADQLKTQ AVDFINYHAS DVLETSGWKS MVVSHPHLVA EAYRSLASAQ 
CPFLGPPRKR LKQS

Genular Protein ID: 2989983607

Symbol: Q9DBZ2_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9DBZ2

Database IDs:

AGR 1 ARBA 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Gene3D 2 Genevisible 1 Google 1 IntAct 1 InterPro 4 KEGG 1 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 2 RefSeq 1 SMART 2 SUPFAM 2

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 425
  • Mass: 47517
  • Checksum: 7B6716666C3D884B
  • Sequence:
    • MSRVPSPPPP AEMSSGPVAE SWCYTQIKVV KFSYMWTINN FSFCREEMGE VIKSSTFSSG 
ANDKLKWCLR VNPKGLDEES KDYLSLYLLL VSCPKSEVRA KFKFSILNAK GEETKAMESQ 
RAYRFVQGKD WGFKKFIRRD FLLDEANGLL PDDKLTLFCE VSVVQDSVNI SGQNTMNMVK 
VPECRLADEL GGLWENSRFT DCCLCVAGQE FQAHKAILAA RSPVFSAMFE HEMEESKKNR 
VEINDVEPEV FKEMMCFIYT GKAPNLDKMA DDLLAAADKY ALERLKVMCE DALCSNLSVE 
NAAEILILAD LHSADQLKTX AXDFINYHAS DVLETSGWKS MVVSHPHLVA EAYRSLAFST 
VPFPGAPRQT LEAILRCCQL GDSIYFPEAA ATVAATDYQV DSAICGAFTL CQGKDCTMTQ 
TLKQH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.