Genular: Defining Cellular Identity and Function

Details for: Sptlc2

Gene ID: 20773

Symbol: Sptlc2

Ensembl ID: ENSMUSG00000021036

Description: serine palmitoyltransferase, long chain base subunit 2

Associated with

Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Sphingolipid de novo biosynthesis
(R-MMU-1660661)
Sphingolipid metabolism
(R-MMU-428157)
Acyltransferase activity
(GO:0016746)
Adipose tissue development
(GO:0060612)
Biosynthetic process
(GO:0009058)
Ceramide biosynthetic process
(GO:0046513)
Endoplasmic reticulum
(GO:0005783)
Lipid metabolic process
(GO:0006629)
Lipophagy
(GO:0061724)
Membrane
(GO:0016020)
Mitochondrion
(GO:0005739)
Positive regulation of lipophagy
(GO:1904504)
Pyridoxal phosphate binding
(GO:0030170)
Serine c-palmitoyltransferase activity
(GO:0004758)
Serine c-palmitoyltransferase complex
(GO:0017059)
Sphinganine biosynthetic process
(GO:0046511)
Sphingolipid biosynthetic process
(GO:0030148)
Sphingolipid metabolic process
(GO:0006665)
Sphingomyelin biosynthetic process
(GO:0006686)
Sphingosine biosynthetic process
(GO:0046512)
Transferase activity
(GO:0016740)

Other Information

Proteins

Long chain base biosynthesis protein 2

Genular Protein ID: 2630656312

Symbol: SPTC2_MOUSE

Name: Long chain base biosynthesis protein 2

UniProtKB Accession Codes:

P97363 P97356

Database IDs:

Citations:

PubMed ID: 8921873

Title: Sphingolipid synthesis: identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase.

PubMed ID: 8921873

DOI: 10.1016/0378-1119(96)00309-5

PubMed ID: 9363775

Title: Human and murine serine-palmitoyl-CoA transferase. Cloning, expression and characterization of the key enzyme in sphingolipid synthesis.

PubMed ID: 9363775

DOI: 10.1111/j.1432-1033.1997.00239.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1317856

Title: Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver.

PubMed ID: 1317856

DOI: 10.1016/s0021-9258(19)49887-6

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21994399

Title: MicroRNA-137/181c regulates serine palmitoyltransferase and in turn amyloid beta, novel targets in sporadic Alzheimer's disease.

PubMed ID: 21994399

DOI: 10.1523/jneurosci.3883-11.2011

PubMed ID: 27818258

Title: Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism.

PubMed ID: 27818258

DOI: 10.1016/j.cmet.2016.10.002

PubMed ID: 28698261

Title: Adipocyte-Specific Deficiency of De Novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Insulin Resistance.

PubMed ID: 28698261

DOI: 10.2337/db16-1232

Sequence Information:

Length: 560
Mass: 62982
Checksum: 6429566979B18D1C
Sequence:

MRPEPGGCCC RRPMRANGCV KNGEVRNGYL RSSTATVAAA GQIHHVTENG GLYKRPFNEA 
FEETPMLVAV LTYVGYGVLT LFGYLRDFLR HWRIEKCHHA TEREEQKDFV SLYQDFENFY 
TRNLYMRIRD NWNRPICSVP GAKVDIMERK SHDYNWSFKY TGNIIKGVIN MGSYNYLGFA 
RNTGSCQEAA AEVLKEYGAG VCSTRQEIGN LDKHEELEKL VARFLGVEAA MTYGMGFATN 
SMNIPALVGK GCLILSDELN HASLVLGARL SGATIRIFKH NNMQSLEKLL KDAIVYGQPR 
TRRPWKKILI LVEGIYSMEG SIVRLPEVIA LKKKYKAYLY LDEAHSIGAL GPSGRGVVDY 
FGLDPEDVDV MMGTFTKSFG ASGGYIGGKK ELIDYLRTHS HSAVYATSMS PPVMEQIITS 
MKCIMGQDGT SLGKECIQQL AENTRYFRRR LKEMGFIIYG NEDSPVVPLM LYMPAKIGAF 
GREMLKRNIG VVVVGFPATP IIESRARFCL SAAHTKEILD TALKEIDEVG DLLQLKYSRH 
RLVPLLDRPF DETTYEETED

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Sptlc2

Associated with

Other Information

Sphingolipid synthesis: identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase. PubMed ID: 8921873

Human and murine serine-palmitoyl-CoA transferase. Cloning, expression and characterization of the key enzyme in sphingolipid synthesis. PubMed ID: 9363775

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver. PubMed ID: 1317856

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

MicroRNA-137/181c regulates serine palmitoyltransferase and in turn amyloid beta, novel targets in sporadic Alzheimer's disease. PubMed ID: 21994399

Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism. PubMed ID: 27818258

Adipocyte-Specific Deficiency of De Novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Insulin Resistance. PubMed ID: 28698261