Genular: Defining Cellular Identity and Function

Details for: Scarb1

Gene ID: 20778

Symbol: Scarb1

Ensembl ID: ENSMUSG00000037936

Description: scavenger receptor class B, member 1

Associated with

Binding and uptake of ligands by scavenger receptors
(R-MMU-2173782)
Hdl clearance
(R-MMU-8964011)
Plasma lipoprotein assembly, remodeling, and clearance
(R-MMU-174824)
Plasma lipoprotein clearance
(R-MMU-8964043)
Scavenging by class b receptors
(R-MMU-3000471)
Transport of small molecules
(R-MMU-382551)
Vesicle-mediated transport
(R-MMU-5653656)
Adhesion of symbiont to host
(GO:0044406)
Amyloid-beta binding
(GO:0001540)
Androgen biosynthetic process
(GO:0006702)
Apolipoprotein a-i binding
(GO:0034186)
Apolipoprotein binding
(GO:0034185)
Blood vessel endothelial cell migration
(GO:0043534)
Carotenoid transport
(GO:0046867)
Caveola
(GO:0005901)
Cell surface
(GO:0009986)
Cholesterol catabolic process
(GO:0006707)
Cholesterol efflux
(GO:0033344)
Cholesterol homeostasis
(GO:0042632)
Cholesterol import
(GO:0070508)
Cholesterol transport
(GO:0030301)
Cytoplasm
(GO:0005737)
Detection of lipopolysaccharide
(GO:0032497)
Endothelial cell proliferation
(GO:0001935)
High-density lipoprotein particle binding
(GO:0008035)
High-density lipoprotein particle clearance
(GO:0034384)
High-density lipoprotein particle receptor activity
(GO:0070506)
High-density lipoprotein particle remodeling
(GO:0034375)
Identical protein binding
(GO:0042802)
Intestinal lipid absorption
(GO:0098856)
Intracellular membrane-bounded organelle
(GO:0043231)
Lipid binding
(GO:0008289)
Lipid transport
(GO:0006869)
Lipopolysaccharide binding
(GO:0001530)
Lipopolysaccharide immune receptor activity
(GO:0001875)
Lipopolysaccharide transport
(GO:0015920)
Low-density lipoprotein particle binding
(GO:0030169)
Low-density lipoprotein particle clearance
(GO:0034383)
Lysosome
(GO:0005764)
Membrane
(GO:0016020)
Microvillus membrane
(GO:0031528)
Phagocytosis, recognition
(GO:0006910)
Phosphatidylserine binding
(GO:0001786)
Phospholipid transport
(GO:0015914)
Plasma lipoprotein particle clearance
(GO:0034381)
Plasma membrane
(GO:0005886)
Positive regulation of cholesterol storage
(GO:0010886)
Positive regulation of nitric-oxide synthase activity
(GO:0051000)
Positive regulation of triglyceride biosynthetic process
(GO:0010867)
Recognition of apoptotic cell
(GO:0043654)
Regulation of phagocytosis
(GO:0050764)
Regulation of phosphatidylcholine catabolic process
(GO:0010899)
Reverse cholesterol transport
(GO:0043691)
Scavenger receptor activity
(GO:0005044)
Triglyceride homeostasis
(GO:0070328)
Vitamin transmembrane transport
(GO:0035461)

Other Information

Proteins

Scavenger receptor class B member 1

Genular Protein ID: 629703219

Symbol: SCRB1_MOUSE

Name: Scavenger receptor class B member 1

UniProtKB Accession Codes:

Q61009 D3Z2V4 Q3TZ42 Q4FK30 Q9CWJ7

Database IDs:

Citations:

PubMed ID: 8560269

Title: Identification of scavenger receptor SR-BI as a high density lipoprotein receptor.

PubMed ID: 8560269

DOI: 10.1126/science.271.5248.518

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9254074

Title: Alternative forms of the scavenger receptor BI (SR-BI).

PubMed ID: 9254074

PubMed ID: 9614139

Title: SR-BII, an isoform of the scavenger receptor BI containing an alternate cytoplasmic tail, mediates lipid transfer between high density lipoprotein and cells.

PubMed ID: 9614139

DOI: 10.1074/jbc.273.24.15241

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21675794

Title: Extracellular disulfide bonds support scavenger receptor class B type I-mediated cholesterol transport.

PubMed ID: 21675794

DOI: 10.1021/bi2005625

Sequence Information:

Length: 509
Mass: 56754
Checksum: 5CFCDD62DD6ECB1C
Sequence:

MGGSSRARWV ALGLGALGLL FAALGVVMIL MVPSLIKQQV LKNVRIDPSS LSFGMWKEIP 
VPFYLSVYFF EVVNPNEVLN GQKPVVRERG PYVYREFRQK VNITFNDNDT VSFVENRSLH 
FQPDKSHGSE SDYIVLPNIL VLGGSILMES KPVSLKLMMT LALVTMGQRA FMNRTVGEIL 
WGYDDPFVHF LNTYLPDMLP IKGKFGLFVG MNNSNSGVFT VFTGVQNFSR IHLVDKWNGL 
SKIDYWHSEQ CNMINGTSGQ MWAPFMTPES SLEFFSPEAC RSMKLTYNES RVFEGIPTYR 
FTAPDTLFAN GSVYPPNEGF CPCRESGIQN VSTCRFGAPL FLSHPHFYNA DPVLSEAVLG 
LNPNPKEHSL FLDIHPVTGI PMNCSVKMQL SLYIKSVKGI GQTGKIEPVV LPLLWFEQSG 
AMGGKPLSTF YTQLVLMPQV LHYAQYVLLG LGGLLLLVPI ICQLRSQEKC FLFWSGSKKG 
SQDKEAIQAY SESLMSPAAK GTVLQEAKL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Scarb1

Associated with

Other Information

Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. PubMed ID: 8560269

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Alternative forms of the scavenger receptor BI (SR-BI). PubMed ID: 9254074

SR-BII, an isoform of the scavenger receptor BI containing an alternate cytoplasmic tail, mediates lipid transfer between high density lipoprotein and cells. PubMed ID: 9614139

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Extracellular disulfide bonds support scavenger receptor class B type I-mediated cholesterol transport. PubMed ID: 21675794