Details for: Srebf1
Associated with
Other Information
Genular Protein ID: 2808319716
Symbol: SRBP1_MOUSE
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16141072
Title: The transcriptional landscape of the mammalian genome.
PubMed ID: 16141072
PubMed ID: 19468303
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
PubMed ID: 19468303
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9062340
Title: Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.
PubMed ID: 9062340
DOI: 10.1172/jci119247
PubMed ID: 10052151
Title: A novel splicing isoform of mouse sterol regulatory element-binding protein-1 (SREBP-1).
PubMed ID: 10052151
DOI: 10.1271/bbb.63.243
PubMed ID: 8833906
Title: Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.
PubMed ID: 8833906
DOI: 10.1172/jci118951
PubMed ID: 9062341
Title: Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.
PubMed ID: 9062341
DOI: 10.1172/jci119248
PubMed ID: 9329978
Title: Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.
PubMed ID: 9329978
DOI: 10.1172/jci119746
PubMed ID: 9784493
Title: Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy.
PubMed ID: 9784493
PubMed ID: 11929849
Title: A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies.
PubMed ID: 11929849
DOI: 10.1093/hmg/11.7.769
PubMed ID: 11782483
Title: Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c.
PubMed ID: 11782483
PubMed ID: 12855691
Title: Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver.
PubMed ID: 12855691
PubMed ID: 16100574
Title: Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.
PubMed ID: 16100574
DOI: 10.1172/jci25614
PubMed ID: 17290224
Title: Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo.
PubMed ID: 17290224
PubMed ID: 19244231
Title: Salt-inducible kinase regulates hepatic lipogenesis by controlling SREBP-1c phosphorylation.
PubMed ID: 19244231
PubMed ID: 19786558
Title: The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors.
PubMed ID: 19786558
PubMed ID: 21183079
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
PubMed ID: 21183079
PubMed ID: 21459323
Title: AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.
PubMed ID: 21459323
PubMed ID: 21531336
Title: Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a.
PubMed ID: 21531336
PubMed ID: 21987372
Title: Antagonism of peripheral hepatic cannabinoid receptor-1 improves liver lipid metabolism in mice: evidence from cultured explants.
PubMed ID: 21987372
DOI: 10.1002/hep.24733
PubMed ID: 28849786
Title: SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology.
PubMed ID: 28849786
PubMed ID: 36804859
Title: Hepatic mitochondrial NAD + transporter SLC25A47 activates AMPKalpha mediating lipid metabolism and tumorigenesis.
PubMed ID: 36804859
Sequence Information:
- Length: 1134
- Mass: 120537
- Checksum: 3D7422406E07A376
- Sequence:
MDELAFGEAA LEQTLAEMCE LDTAVLNDIE DMLQLINNQD SDFPGLFDAP YAGGETGDTG PSSPGANSPE SFSSASLASS LEAFLGGPKV TPAPLSPPPS APAALKMYPS VSPFSPGPGI KEEPVPLTIL QPAAPQPSPG TLLPPSFPAP PVQLSPAPVL GYSSLPSGFS GTLPGNTQQP PSSLPLAPAP GVLPTPALHT QVQSLASQQP LPASAAPRTN TVTSQVQQVP VVLQPHFIKA DSLLLTAVKT DAGATVKTAG ISTLAPGTAV QAGPLQTLVS GGTILATVPL VVDTDKLPIH RLAAGSKALG SAQSRGEKRT AHNAIEKRYR SSINDKIVEL KDLVVGTEAK LNKSAVLRKA IDYIRFLQHS NQKLKQENLT LRSAHKSKSL KDLVSACGSG GGTDVSMEGM KPEVVETLTP PPSDAGSPSQ SSPLSFGSRA SSSGGSDSEP DSPAFEDSQV KAQRLPSHSR GMLDRSRLAL CVLAFLCLTC NPLASLFGWG ILTPSDATGT HRSSGRSMLE AESRDGSNWT QWLLPPLVWL ANGLLVLACL ALLFVYGEPV TRPHSGPAVH FWRHRKQADL DLARGDFPQA AQQLWLALQA LGRPLPTSNL DLACSLLWNL IRHLLQRLWV GRWLAGQAGG LLRDRGLRKD ARASARDAAV VYHKLHQLHA MGKYTGGHLA ASNLALSALN LAECAGDAIS MATLAEIYVA AALRVKTSLP RALHFLTRFF LSSARQACLA QSGSVPLAMQ WLCHPVGHRF FVDGDWAVHG APPESLYSVA GNPVDPLAQV TRLFREHLLE RALNCIAQPS PGAADGDREF SDALGYLQLL NSCSDAAGAP ACSFSVSSSM AATTGPDPVA KWWASLTAVV IHWLRRDEEA AERLYPLVEH IPQVLQDTER PLPRAALYSF KAARALLDHR KVESSPASLA ICEKASGYLR DSLASTPTGS SIDKAMQLLL CDLLLVARTS LWQRQQSPAS VQVAHGTSNG PQASALELRG FQHDLSSLRR LAQSFRPAMR RVFLHEATAR LMAGASPART HQLLDRSLRR RAGSSGKGGT TAELEPRPTW REHTEALLLA SCYLPPAFLS APGQRMSMLA EAARTVEKLG DHRLLLDCQQ MLLRLGGGTT VTSS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.