Genular: Defining Cellular Identity and Function

Details for: Srebf2

Gene ID: 20788

Symbol: Srebf2

Ensembl ID: ENSMUSG00000022463

Description: sterol regulatory element binding factor 2

Associated with

Cholesterol biosynthesis
(R-MMU-191273)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Metabolism of steroids
(R-MMU-8957322)
Regulation of cholesterol biosynthesis by srebp (srebf)
(R-MMU-1655829)
Cellular response to starvation
(GO:0009267)
Cholesterol homeostasis
(GO:0042632)
Cholesterol metabolic process
(GO:0008203)
Chromatin binding
(GO:0003682)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Dendrite
(GO:0030425)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
E-box binding
(GO:0070888)
Endoplasmic reticulum
(GO:0005783)
Golgi apparatus
(GO:0005794)
Intracellular membrane-bounded organelle
(GO:0043231)
Lipid metabolic process
(GO:0006629)
Membrane
(GO:0016020)
Negative regulation of cholesterol efflux
(GO:0090370)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of cholesterol biosynthetic process
(GO:0045542)
Positive regulation of cholesterol storage
(GO:0010886)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of mirna transcription
(GO:1902895)
Positive regulation of myelination
(GO:0031643)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to hormone
(GO:0009725)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Srebp-scap-insig complex
(GO:0032937)
Srebp signaling pathway
(GO:0032933)
Steroid metabolic process
(GO:0008202)
Transcription cis-regulatory region binding
(GO:0000976)

Other Information

Proteins

SRBP2_MOUSE

Genular Protein ID: 3833651088

Symbol: SRBP2_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3U1N2 Q925C2 Q9ESZ4

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 11929849

Title: A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies.

PubMed ID: 11929849

DOI: 10.1093/hmg/11.7.769

PubMed ID: 12668174

Title: Acetyl-CoA carboxylase and SREBP expression during peripheral nervous system myelination.

PubMed ID: 12668174

DOI: 10.1016/s1388-1981(03)00041-6

PubMed ID: 9616204

Title: Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

PubMed ID: 9616204

DOI: 10.1172/jci2961

PubMed ID: 10397761

Title: Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip.

PubMed ID: 10397761

DOI: 10.1091/mbc.10.7.2221

PubMed ID: 11283257

Title: Dimerization of sterol regulatory element-binding protein 2 via the helix-loop-helix-leucine zipper domain is a prerequisite for its nuclear localization mediated by importin beta.

PubMed ID: 11283257

DOI: 10.1128/mcb.21.8.2779-2789.2001

PubMed ID: 11994399

Title: SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.

PubMed ID: 11994399

DOI: 10.1172/jci15593

PubMed ID: 16100574

Title: Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.

PubMed ID: 16100574

DOI: 10.1172/jci25614

PubMed ID: 21459323

Title: AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.

PubMed ID: 21459323

DOI: 10.1016/j.cmet.2011.03.009

PubMed ID: 29068315

Title: Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP.

PubMed ID: 29068315

DOI: 10.7554/elife.28766

PubMed ID: 28849786

Title: SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology.

PubMed ID: 28849786

DOI: 10.1038/nrendo.2017.91

PubMed ID: 36804859

Title: Hepatic mitochondrial NAD + transporter SLC25A47 activates AMPKalpha mediating lipid metabolism and tumorigenesis.

PubMed ID: 36804859

DOI: 10.1097/hep.0000000000000314

Sequence Information:

Length: 1130
Mass: 122911
Checksum: 052E858B0C3945F2
Sequence:

MDESSELGVL ETMETLTELG DELTLGDIDE MLQFVSNQVG EFPDLFSEQL CSSFPGGGSN 
GGSGNNSSGR GNNGGATDPA VQRSFSQVPL STFSPSAASP QAPALQVKVS PTPPRATPVL 
QPRPQPQPQP PAQLQQQTVM ITPTFSTAPQ TRIIQQPLIY QNAATSFQVL QPQVQSLVTS 
PQVQPVTIQQ QVQTVQAQRV LTQTANGTLQ TLAPATVQTV AAPQVQQVPV LVQPQIIKTD 
SLVLTTLKTD GSPVMAAVQN PALTALTAPI QTAALQVPTL VGSNGTILTT MPVMMGQEKV 
PIKQVPGGVK QLDPPKEGER RTTHNIIEKR YRSSINDKII ELKDLVMGTD AKMHKSGVLR 
KAIDYIKYLQ QVNHKLRQEN MVLKLANQKN KLLKGIDLGS LVDSDVDLKI DDFNQNVLLM 
SPPASDSGSQ AGFSPYSIDS EPGSPLLDDA KVKDEPDSPP VALGMVDRSR ILLCVLTFLG 
LSFNPLTSLL QWGGAHNTDQ HPYSGSGRSV LSLESGAGGW FDWMVPTLLL WLVNGVIVLS 
VFVKLLVHGE PVIRPHSRPS VTFWRHRKQA DLDLAKGDFA AAAANLQTCL SVLGRALPTS 
RLDLACSLSW NVIRYSLQKL RLVRWLLKKV FQRWRATPAT AAGFEDEAKS SARDAALAYH 
RLHQLHITGK LPAGSACSDV HMALCAVNLA ECAEEKILPS TLIEIHLTAA MGLKTRCGGK 
LGFLASYFLN RAQSLCGPEH STVPDSLRWL CHPLGQKFFM ERSWSIKSAA KESLYCAQRS 
PADPIAQVHQ AFCKNLLERA VESLVKPQAK KKAGDQEEES CEFSSALEYL KLLHSFVDSV 
GFVTSPFSSS SVLRSALGPD VICRWWTSAV TMAISWLQGD DAAVRSRFTE VERVPKALEV 
TESPLVKAVF YTCRAMHASL SGKADGQQNS FCHCERASGH LWSSLNVSGT TSDPSLNHVI 
QLFTCDLLLS LRTALWQKQA SASQLLGETY HASGTELAGF QRDLGSLRRL AHSFRPAYRK 
VFLHEATVRL MAGASPTRTH QLLEHSLRRR PTQNTKHGEV DTWPGQRERA TAILLACRHL 
PLSFLSSPGQ RAVLLAEAAR TLEKVGDRRS CSDCQQMIVK LGGGTAIAAS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Srebf2

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies. PubMed ID: 11929849

Acetyl-CoA carboxylase and SREBP expression during peripheral nervous system myelination. PubMed ID: 12668174

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. PubMed ID: 9616204

Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip. PubMed ID: 10397761

Dimerization of sterol regulatory element-binding protein 2 via the helix-loop-helix-leucine zipper domain is a prerequisite for its nuclear localization mediated by importin beta. PubMed ID: 11283257

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. PubMed ID: 11994399

Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. PubMed ID: 16100574

AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. PubMed ID: 21459323

Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP. PubMed ID: 29068315

SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology. PubMed ID: 28849786

Hepatic mitochondrial NAD + transporter SLC25A47 activates AMPKalpha mediating lipid metabolism and tumorigenesis. PubMed ID: 36804859