AKT2 | ENSG00000105221 | NCBI 208

Details for: AKT2

Gene ID: 208

Symbol: AKT2

Ensembl ID: ENSG00000105221

Description: AKT serine/threonine kinase 2

Associated with

Activation of akt2
(R-HSA-165158)
Activation of bad and translocation to mitochondria
(R-HSA-111447)
Activation of bh3-only proteins
(R-HSA-114452)
Adaptive immune system
(R-HSA-1280218)
Akt-mediated inactivation of foxo1a
(R-HSA-211163)
Akt phosphorylates targets in the cytosol
(R-HSA-198323)
Akt phosphorylates targets in the nucleus
(R-HSA-198693)
Apoptosis
(R-HSA-109581)
Cd28 co-stimulation
(R-HSA-389356)
Cd28 dependent pi3k/akt signaling
(R-HSA-389357)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Constitutive signaling by akt1 e17k in cancer
(R-HSA-5674400)
Costimulation by the cd28 family
(R-HSA-388841)
Ctla4 inhibitory signaling
(R-HSA-389513)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Cytokine signaling in immune system
(R-HSA-1280215)
Deactivation of the beta-catenin transactivating complex
(R-HSA-3769402)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downregulation of erbb2 signaling
(R-HSA-8863795)
Downregulation of erbb2:erbb3 signaling
(R-HSA-1358803)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Flt3 signaling
(R-HSA-9607240)
Foxo-mediated transcription
(R-HSA-9614085)
G-protein beta:gamma signalling
(R-HSA-397795)
G1/s transition
(R-HSA-69206)
G beta:gamma signalling through pi3kgamma
(R-HSA-392451)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gpcr downstream signalling
(R-HSA-388396)
Igf1r signaling cascade
(R-HSA-2428924)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Inhibition of tsc complex formation by pkb
(R-HSA-165181)
Insulin receptor signalling cascade
(R-HSA-74751)
Intracellular signaling by second messengers
(R-HSA-9006925)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Membrane trafficking
(R-HSA-199991)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mtor signalling
(R-HSA-165159)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Pde3b signalling
(R-HSA-165160)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pip3 activates akt signaling
(R-HSA-1257604)
Pkb-mediated events
(R-HSA-109703)
Programmed cell death
(R-HSA-5357801)
Pten regulation
(R-HSA-6807070)
Rab gefs exchange gtp for gdp on rabs
(R-HSA-8876198)
Rab regulation of trafficking
(R-HSA-9007101)
Regulation of beta-cell development
(R-HSA-186712)
Regulation of gene expression in beta cells
(R-HSA-210745)
Regulation of localization of foxo transcription factors
(R-HSA-9614399)
Regulation of pten stability and activity
(R-HSA-8948751)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through acetylation
(R-HSA-6804758)
Regulation of tp53 activity through association with co-factors
(R-HSA-6804759)
Regulation of tp53 degradation
(R-HSA-6804757)
Regulation of tp53 expression and degradation
(R-HSA-6806003)
Rna polymerase ii transcription
(R-HSA-73857)
Runx2 regulates genes involved in cell migration
(R-HSA-8941332)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 targets host intracellular signalling and regulatory pathways
(R-HSA-9755779)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Signaling by erbb2
(R-HSA-1227986)
Signaling by gpcr
(R-HSA-372790)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Signaling by vegf
(R-HSA-194138)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by runx2
(R-HSA-8878166)
Transcriptional regulation by tp53
(R-HSA-3700989)
Translocation of slc2a4 (glut4) to the plasma membrane
(R-HSA-1445148)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Vegfr2 mediated vascular permeability
(R-HSA-5218920)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Atp binding
(GO:0005524)
Protein binding
(GO:0005515)
Protein serine/threonine kinase activity
(GO:0004674)

Other Information

Proteins

RAC-beta serine/threonine-protein kinase
B4DG79_HUMAN

Genular Protein ID: 1701018404

Symbol: AKT2_HUMAN

Name: RAC-beta serine/threonine-protein kinase

UniProtKB Accession Codes:

P31751 B2RBD8 Q05BV0 Q0VAN0 Q0VAN1 Q68GC0

Database IDs:

Citations:

PubMed ID: 1801921

Title: Molecular cloning of a second form of rac protein kinase.

PubMed ID: 1801921

DOI: 10.1091/mbc.2.12.1001

PubMed ID: 1409633

Title: AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.

PubMed ID: 1409633

DOI: 10.1073/pnas.89.19.9267

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9512493

Title: Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha.

PubMed ID: 9512493

DOI: 10.1042/bj3310299

PubMed ID: 10983986

Title: The protooncogene TCL1 is an Akt kinase coactivator.

PubMed ID: 10983986

DOI: 10.1016/s1097-2765(00)00039-3

PubMed ID: 15890450

Title: Activation of a GST-tagged AKT2/PKBbeta.

PubMed ID: 15890450

DOI: 10.1016/j.bbagen.2005.04.002

PubMed ID: 16792529

Title: A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda.

PubMed ID: 16792529

DOI: 10.1042/bj20060511

PubMed ID: 16540465

Title: Kinetic mechanism of AKT/PKB enzyme family.

PubMed ID: 16540465

DOI: 10.1074/jbc.m601384200

PubMed ID: 17565718

Title: Akt2 is implicated in skeletal muscle differentiation and specifically binds Prohibitin2/REA.

PubMed ID: 17565718

DOI: 10.1002/jcp.21177

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20059950

Title: The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt.

PubMed ID: 20059950

DOI: 10.1016/j.devcel.2009.09.007

PubMed ID: 19139280

Title: ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization.

PubMed ID: 19139280

DOI: 10.1128/mcb.00754-08

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19713527

Title: The E3 ligase TRAF6 regulates Akt ubiquitination and activation.

PubMed ID: 19713527

DOI: 10.1126/science.1175065

PubMed ID: 20167810

Title: Akt2 and Akt3 play a pivotal role in malignant gliomas.

PubMed ID: 20167810

DOI: 10.1093/neuonc/nop026

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21620960

Title: Akt signalling in health and disease.

PubMed ID: 21620960

DOI: 10.1016/j.cellsig.2011.05.004

PubMed ID: 21432781

Title: Akt1 and Akt2: differentiating the aktion.

PubMed ID: 21432781

DOI: 10.14670/hh-26.651

PubMed ID: 21737686

Title: Ankrd2/ARPP is a novel Akt2 specific substrate and regulates myogenic differentiation upon cellular exposure to H(2)O(2).

PubMed ID: 21737686

DOI: 10.1091/mbc.e10-11-0928

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12086620

Title: Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation.

PubMed ID: 12086620

DOI: 10.1016/s1097-2765(02)00550-6

PubMed ID: 12434148

Title: Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP.

PubMed ID: 12434148

DOI: 10.1038/nsb870

PubMed ID: 12517337

Title: Crystal structure of an inactive Akt2 kinase domain.

PubMed ID: 12517337

DOI: 10.1016/s0969-2126(02)00937-1

PubMed ID: 14755158

Title: Solution structure and backbone dynamics of the pleckstrin homology domain of the human protein kinase B (PKB/Akt). Interaction with inositol phosphates.

PubMed ID: 14755158

DOI: 10.1023/b:jnmr.0000013836.62154.c2

PubMed ID: 31204173

Title: Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis.

PubMed ID: 31204173

DOI: 10.1016/j.devcel.2019.05.022

PubMed ID: 17275837

Title: A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera.

PubMed ID: 17275837

DOI: 10.1016/j.jmb.2007.01.004

PubMed ID: 18800763

Title: Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.

PubMed ID: 18800763

DOI: 10.1021/jm8004527

PubMed ID: 19179070

Title: Aminofurazans as potent inhibitors of AKT kinase.

PubMed ID: 19179070

DOI: 10.1016/j.bmcl.2009.01.002

PubMed ID: 15166380

Title: A family with severe insulin resistance and diabetes due to a mutation in AKT2.

PubMed ID: 15166380

DOI: 10.1126/science.1096706

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 19164855

Title: Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis.

PubMed ID: 19164855

DOI: 10.1172/jci37432

PubMed ID: 21979934

Title: An activating mutation of AKT2 and human hypoglycemia.

PubMed ID: 21979934

DOI: 10.1126/science.1210878

Sequence Information:

Length: 481
Mass: 55769
Checksum: B18C87A7246BFB24
Sequence:

MNEVSVIKEG WLHKRGEYIK TWRPRYFLLK SDGSFIGYKE RPEAPDQTLP PLNNFSVAEC 
QLMKTERPRP NTFVIRCLQW TTVIERTFHV DSPDEREEWM RAIQMVANSL KQRAPGEDPM 
DYKCGSPSDS STTEEMEVAV SKARAKVTMN DFDYLKLLGK GTFGKVILVR EKATGRYYAM 
KILRKEVIIA KDEVAHTVTE SRVLQNTRHP FLTALKYAFQ THDRLCFVME YANGGELFFH 
LSRERVFTEE RARFYGAEIV SALEYLHSRD VVYRDIKLEN LMLDKDGHIK ITDFGLCKEG 
ISDGATMKTF CGTPEYLAPE VLEDNDYGRA VDWWGLGVVM YEMMCGRLPF YNQDHERLFE 
LILMEEIRFP RTLSPEAKSL LAGLLKKDPK QRLGGGPSDA KEVMEHRFFL SINWQDVVQK 
KLLPPFKPQV TSEVDTRYFD DEFTAQSITI TPPDRYDSLG LLELDQRTHF PQFSYSASIR 
E

Genular Protein ID: 3904952016

Symbol: B4DG79_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DG79

Database IDs:

Sequence Information:

Length: 419
Mass: 48502
Checksum: 67AEDEBB2CDC2D53
Sequence:

MKTERPRPNT FVIRCLQWTT VIERTFHVDS PDEREEWMRA IQMVANSLKQ RAPGEDPMDY 
KCGSPSDSST TEEMEVAVSK ARAKVTMNDF DYLKLLGKGT FGKVILVREK ATGRYYAMKI 
LRKEVIIAKD EVAHTVTESR VLQNTRHPFL TALKYAFQTH DRLCFVMEYA NGGELFFHLS 
RERVFTEERA RFYGAEIVSA LEYLHSRDVV YRDIKLENLM LDKDGHIKIT DFGLCKEGIS 
DGATMKTFCG TPEYLAPEVL EDNDYGRAVD WWGLGVVMYE MMCGRLPFYN QDHERLFELI 
LMEEIRFPRT LSPEAKSLLA GLLKKDPKQR LGGGPSDAKE VMEHRFFLSI NWQDVVQKKL 
LPPFKPQVTS EVDTRYFDDE FTAQSITITP PDRYDSLGLL ELDQRTHFPQ FSYSASIRE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: AKT2

Associated with

Other Information

Molecular cloning of a second form of rac protein kinase. PubMed ID: 1801921

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. PubMed ID: 1409633

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha. PubMed ID: 9512493

The protooncogene TCL1 is an Akt kinase coactivator. PubMed ID: 10983986

Activation of a GST-tagged AKT2/PKBbeta. PubMed ID: 15890450

A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda. PubMed ID: 16792529

Kinetic mechanism of AKT/PKB enzyme family. PubMed ID: 16540465

Akt2 is implicated in skeletal muscle differentiation and specifically binds Prohibitin2/REA. PubMed ID: 17565718

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt. PubMed ID: 20059950

ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization. PubMed ID: 19139280

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

The E3 ligase TRAF6 regulates Akt ubiquitination and activation. PubMed ID: 19713527

Akt2 and Akt3 play a pivotal role in malignant gliomas. PubMed ID: 20167810

Initial characterization of the human central proteome. PubMed ID: 21269460

Akt signalling in health and disease. PubMed ID: 21620960

Akt1 and Akt2: differentiating the aktion. PubMed ID: 21432781

Ankrd2/ARPP is a novel Akt2 specific substrate and regulates myogenic differentiation upon cellular exposure to H(2)O(2). PubMed ID: 21737686

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation. PubMed ID: 12086620

Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP. PubMed ID: 12434148

Crystal structure of an inactive Akt2 kinase domain. PubMed ID: 12517337

Solution structure and backbone dynamics of the pleckstrin homology domain of the human protein kinase B (PKB/Akt). Interaction with inositol phosphates. PubMed ID: 14755158

Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis. PubMed ID: 31204173

A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera. PubMed ID: 17275837

Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. PubMed ID: 18800763

Aminofurazans as potent inhibitors of AKT kinase. PubMed ID: 19179070

A family with severe insulin resistance and diabetes due to a mutation in AKT2. PubMed ID: 15166380

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis. PubMed ID: 19164855

An activating mutation of AKT2 and human hypoglycemia. PubMed ID: 21979934