AKT2 | ENSG00000105221 | NCBI 208

Details for: AKT2

Gene ID: 208

Symbol: AKT2

Ensembl ID: ENSG00000105221

Description: AKT serine/threonine kinase 2

Associated with

Activation of akt2
(R-HSA-165158)
Activation of bad and translocation to mitochondria
(R-HSA-111447)
Activation of bh3-only proteins
(R-HSA-114452)
Adaptive immune system
(R-HSA-1280218)
Akt-mediated inactivation of foxo1a
(R-HSA-211163)
Akt phosphorylates targets in the cytosol
(R-HSA-198323)
Akt phosphorylates targets in the nucleus
(R-HSA-198693)
Apoptosis
(R-HSA-109581)
Cd28 co-stimulation
(R-HSA-389356)
Cd28 dependent pi3k/akt signaling
(R-HSA-389357)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Constitutive signaling by akt1 e17k in cancer
(R-HSA-5674400)
Costimulation by the cd28 family
(R-HSA-388841)
Ctla4 inhibitory signaling
(R-HSA-389513)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Cytokine signaling in immune system
(R-HSA-1280215)
Deactivation of the beta-catenin transactivating complex
(R-HSA-3769402)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downregulation of erbb2 signaling
(R-HSA-8863795)
Downregulation of erbb2:erbb3 signaling
(R-HSA-1358803)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Flt3 signaling
(R-HSA-9607240)
Foxo-mediated transcription
(R-HSA-9614085)
G-protein beta:gamma signalling
(R-HSA-397795)
G1/s transition
(R-HSA-69206)
G beta:gamma signalling through pi3kgamma
(R-HSA-392451)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gpcr downstream signalling
(R-HSA-388396)
Igf1r signaling cascade
(R-HSA-2428924)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Inhibition of tsc complex formation by pkb
(R-HSA-165181)
Insulin receptor signalling cascade
(R-HSA-74751)
Intracellular signaling by second messengers
(R-HSA-9006925)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Membrane trafficking
(R-HSA-199991)
Mitf-m-dependent gene expression
(R-HSA-9856651)
Mitf-m-regulated melanocyte development
(R-HSA-9730414)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mtor signalling
(R-HSA-165159)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Pde3b signalling
(R-HSA-165160)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pip3 activates akt signaling
(R-HSA-1257604)
Pkb-mediated events
(R-HSA-109703)
Programmed cell death
(R-HSA-5357801)
Pten regulation
(R-HSA-6807070)
Rab gefs exchange gtp for gdp on rabs
(R-HSA-8876198)
Rab regulation of trafficking
(R-HSA-9007101)
Regulation of beta-cell development
(R-HSA-186712)
Regulation of gene expression in beta cells
(R-HSA-210745)
Regulation of localization of foxo transcription factors
(R-HSA-9614399)
Regulation of mitf-m-dependent genes involved in pigmentation
(R-HSA-9824585)
Regulation of pten stability and activity
(R-HSA-8948751)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through acetylation
(R-HSA-6804758)
Regulation of tp53 activity through association with co-factors
(R-HSA-6804759)
Regulation of tp53 degradation
(R-HSA-6804757)
Regulation of tp53 expression and degradation
(R-HSA-6806003)
Rna polymerase ii transcription
(R-HSA-73857)
Runx2 regulates genes involved in cell migration
(R-HSA-8941332)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 targets host intracellular signalling and regulatory pathways
(R-HSA-9755779)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Signaling by erbb2
(R-HSA-1227986)
Signaling by gpcr
(R-HSA-372790)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Signaling by vegf
(R-HSA-194138)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by runx2
(R-HSA-8878166)
Transcriptional regulation by tp53
(R-HSA-3700989)
Translocation of slc2a4 (glut4) to the plasma membrane
(R-HSA-1445148)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Vegfr2 mediated vascular permeability
(R-HSA-5218920)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Protein serine/threonine kinase activity
(GO:0004674)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 206.5637
Cell Significance Index: -32.1300
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 122.9285
Cell Significance Index: -31.1800
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 81.7822
Cell Significance Index: -33.6900
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 69.0203
Cell Significance Index: -28.0400
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 67.8002
Cell Significance Index: -32.0100
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 61.0535
Cell Significance Index: -31.4100
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 47.7630
Cell Significance Index: -32.0500
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 29.4215
Cell Significance Index: -28.0900
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 27.3732
Cell Significance Index: -33.7500
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 11.0271
Cell Significance Index: -29.5400
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.6694
Cell Significance Index: -34.2100
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 6.8583
Cell Significance Index: -15.0100
Cell Name: decidual cell (CL2000002)
Fold Change: 1.8839
Cell Significance Index: 30.2300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.6530
Cell Significance Index: 331.5900
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.4562
Cell Significance Index: 236.8300
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.2409
Cell Significance Index: 1120.4000
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.2141
Cell Significance Index: 240.9500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.1544
Cell Significance Index: 15.7500
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.0479
Cell Significance Index: 28.0800
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.0101
Cell Significance Index: 65.1700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.8682
Cell Significance Index: 94.4400
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.8314
Cell Significance Index: 49.9100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.7829
Cell Significance Index: 21.8800
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.6990
Cell Significance Index: 250.7100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.6576
Cell Significance Index: 90.3100
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.6484
Cell Significance Index: 17.6500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.5592
Cell Significance Index: 68.7600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5541
Cell Significance Index: 15.9700
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5500
Cell Significance Index: 99.1400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.4883
Cell Significance Index: 21.6000
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.4601
Cell Significance Index: 5.4900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.4374
Cell Significance Index: 22.7200
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4206
Cell Significance Index: 29.0900
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.4191
Cell Significance Index: 15.8700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4187
Cell Significance Index: 9.0700
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4184
Cell Significance Index: 228.5200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.4183
Cell Significance Index: 49.3300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3643
Cell Significance Index: 69.3300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.3128
Cell Significance Index: 14.5900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3113
Cell Significance Index: 14.1100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.3094
Cell Significance Index: 19.5000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3063
Cell Significance Index: 135.4200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3051
Cell Significance Index: 23.4100
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2968
Cell Significance Index: 7.4200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.2700
Cell Significance Index: 15.1500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.2444
Cell Significance Index: 12.8300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2362
Cell Significance Index: 444.7500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.2096
Cell Significance Index: 12.8800
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.2064
Cell Significance Index: 2.5600
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.1860
Cell Significance Index: 12.5100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.1620
Cell Significance Index: 12.0700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1483
Cell Significance Index: 94.2000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1350
Cell Significance Index: 13.3500
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.1222
Cell Significance Index: 1.5700
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0938
Cell Significance Index: 12.0200
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0888
Cell Significance Index: 11.4700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0881
Cell Significance Index: 4.1400
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0538
Cell Significance Index: 82.7600
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0495
Cell Significance Index: 91.2400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0437
Cell Significance Index: 7.4700
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0210
Cell Significance Index: 0.3600
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0140
Cell Significance Index: 19.0300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0097
Cell Significance Index: 4.4200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0056
Cell Significance Index: 0.1500
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0068
Cell Significance Index: -0.1800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0098
Cell Significance Index: -7.2200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0124
Cell Significance Index: -9.3700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0146
Cell Significance Index: -2.1300
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0251
Cell Significance Index: -0.4200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0254
Cell Significance Index: -0.5400
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0297
Cell Significance Index: -0.7900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0328
Cell Significance Index: -24.2900
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0471
Cell Significance Index: -4.8100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0505
Cell Significance Index: -28.4700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0572
Cell Significance Index: -35.6900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0670
Cell Significance Index: -4.7400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0700
Cell Significance Index: -2.4600
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0856
Cell Significance Index: -2.2000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0923
Cell Significance Index: -26.5600
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1557
Cell Significance Index: -5.4100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1641
Cell Significance Index: -19.1200
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1670
Cell Significance Index: -35.1700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1794
Cell Significance Index: -5.7500
Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: -0.1884
Cell Significance Index: -0.8200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1963
Cell Significance Index: -22.4900
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.2013
Cell Significance Index: -4.1800
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2148
Cell Significance Index: -6.1300
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.2289
Cell Significance Index: -3.8600
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2292
Cell Significance Index: -6.5700
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2305
Cell Significance Index: -24.0000
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.2394
Cell Significance Index: -5.7400
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.2618
Cell Significance Index: -5.1100
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.3068
Cell Significance Index: -3.2600
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.3303
Cell Significance Index: -9.7000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3347
Cell Significance Index: -26.5100
Cell Name: peg cell (CL4033014)
Fold Change: -0.3367
Cell Significance Index: -7.7800
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.4173
Cell Significance Index: -6.1600
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.4615
Cell Significance Index: -11.7900
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.4680
Cell Significance Index: -8.6500
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.4714
Cell Significance Index: -6.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Serine/threonine kinase**: AKT2 is a member of the AGC kinase family, which is a group of serine/threonine kinases that play critical roles in various cellular processes. 2. **Phosphorylation-dependent activation**: AKT2 is activated by phosphorylation at specific sites, which triggers the activation of downstream targets. 3. **Dual localization**: AKT2 is localized in both the cytosol and nucleus, where it regulates various cellular processes. 4. **Signaling versatility**: AKT2 is involved in numerous signaling pathways, including those involved in cell survival, proliferation, metabolism, and immune response. **Pathways and Functions** 1. **PI3K/AKT signaling pathway**: AKT2 is a key component of the PI3K/AKT signaling pathway, which regulates cell survival, proliferation, and metabolism. 2. **Apoptosis regulation**: AKT2 is involved in regulating apoptosis, either by promoting cell survival or inhibiting cell death. 3. **Cell cycle regulation**: AKT2 regulates the cell cycle, particularly at the G1/S transition, by phosphorylating and activating downstream targets. 4. **Immune response**: AKT2 is involved in regulating immune responses, including the activation of immune cells and the production of cytokines. 5. **Cancer regulation**: AKT2 is often overexpressed in cancer cells, where it promotes cell survival, proliferation, and metastasis. 6. **Neurotransmission**: AKT2 is involved in regulating neurotransmission, particularly in the central nervous system. **Clinical Significance** 1. **Cancer therapy**: AKT2 is a potential therapeutic target in cancer treatment, as its overexpression is associated with poor prognosis. 2. **Neurodegenerative diseases**: AKT2 is involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Immune disorders**: AKT2 is involved in regulating immune responses, and its dysregulation is associated with immune disorders, such as autoimmune diseases. 4. **Cardiovascular disease**: AKT2 is involved in regulating cardiovascular function, and its dysregulation is associated with cardiovascular disease. 5. **Infectious diseases**: AKT2 is involved in regulating immune responses to infectious diseases, such as HIV and SARS-CoV-2. In conclusion, AKT2 is a critical regulator of various cellular processes, including cell survival, proliferation, metabolism, and immune response. Its dysregulation is associated with various diseases, including cancer, neurodegenerative diseases, immune disorders, cardiovascular disease, and infectious diseases. Further research is needed to fully understand the role of AKT2 in human disease and to develop effective therapeutic strategies.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

RAC-beta serine/threonine-protein kinase
B4DG79_HUMAN

Genular Protein ID: 1701018404

Symbol: AKT2_HUMAN

Name: RAC-beta serine/threonine-protein kinase

UniProtKB Accession Codes:

P31751 B2RBD8 Q05BV0 Q0VAN0 Q0VAN1 Q68GC0

Database IDs:

Citations:

PubMed ID: 1801921

Title: Molecular cloning of a second form of rac protein kinase.

PubMed ID: 1801921

DOI: 10.1091/mbc.2.12.1001

PubMed ID: 1409633

Title: AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.

PubMed ID: 1409633

DOI: 10.1073/pnas.89.19.9267

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9512493

Title: Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha.

PubMed ID: 9512493

DOI: 10.1042/bj3310299

PubMed ID: 10983986

Title: The protooncogene TCL1 is an Akt kinase coactivator.

PubMed ID: 10983986

DOI: 10.1016/s1097-2765(00)00039-3

PubMed ID: 15890450

Title: Activation of a GST-tagged AKT2/PKBbeta.

PubMed ID: 15890450

DOI: 10.1016/j.bbagen.2005.04.002

PubMed ID: 16792529

Title: A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda.

PubMed ID: 16792529

DOI: 10.1042/bj20060511

PubMed ID: 16540465

Title: Kinetic mechanism of AKT/PKB enzyme family.

PubMed ID: 16540465

DOI: 10.1074/jbc.m601384200

PubMed ID: 17565718

Title: Akt2 is implicated in skeletal muscle differentiation and specifically binds Prohibitin2/REA.

PubMed ID: 17565718

DOI: 10.1002/jcp.21177

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20059950

Title: The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt.

PubMed ID: 20059950

DOI: 10.1016/j.devcel.2009.09.007

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19713527

Title: The E3 ligase TRAF6 regulates Akt ubiquitination and activation.

PubMed ID: 19713527

DOI: 10.1126/science.1175065

PubMed ID: 20167810

Title: Akt2 and Akt3 play a pivotal role in malignant gliomas.

PubMed ID: 20167810

DOI: 10.1093/neuonc/nop026

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21620960

Title: Akt signalling in health and disease.

PubMed ID: 21620960

DOI: 10.1016/j.cellsig.2011.05.004

PubMed ID: 21432781

Title: Akt1 and Akt2: differentiating the aktion.

PubMed ID: 21432781

DOI: 10.14670/hh-26.651

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31204173

Title: Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis.

PubMed ID: 31204173

DOI: 10.1016/j.devcel.2019.05.022

PubMed ID: 12086620

Title: Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation.

PubMed ID: 12086620

DOI: 10.1016/s1097-2765(02)00550-6

PubMed ID: 12434148

Title: Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP.

PubMed ID: 12434148

DOI: 10.1038/nsb870

PubMed ID: 12517337

Title: Crystal structure of an inactive Akt2 kinase domain.

PubMed ID: 12517337

DOI: 10.1016/s0969-2126(02)00937-1

PubMed ID: 14755158

Title: Solution structure and backbone dynamics of the pleckstrin homology domain of the human protein kinase B (PKB/Akt). Interaction with inositol phosphates.

PubMed ID: 14755158

DOI: 10.1023/b:jnmr.0000013836.62154.c2

PubMed ID: 17275837

Title: A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera.

PubMed ID: 17275837

DOI: 10.1016/j.jmb.2007.01.004

PubMed ID: 18800763

Title: Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.

PubMed ID: 18800763

DOI: 10.1021/jm8004527

PubMed ID: 19179070

Title: Aminofurazans as potent inhibitors of AKT kinase.

PubMed ID: 19179070

DOI: 10.1016/j.bmcl.2009.01.002

PubMed ID: 15166380

Title: A family with severe insulin resistance and diabetes due to a mutation in AKT2.

PubMed ID: 15166380

DOI: 10.1126/science.1096706

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 19164855

Title: Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis.

PubMed ID: 19164855

DOI: 10.1172/jci37432

PubMed ID: 21979934

Title: An activating mutation of AKT2 and human hypoglycemia.

PubMed ID: 21979934

DOI: 10.1126/science.1210878

Sequence Information:

Length: 481
Mass: 55769
Checksum: B18C87A7246BFB24
Sequence:

MNEVSVIKEG WLHKRGEYIK TWRPRYFLLK SDGSFIGYKE RPEAPDQTLP PLNNFSVAEC 
QLMKTERPRP NTFVIRCLQW TTVIERTFHV DSPDEREEWM RAIQMVANSL KQRAPGEDPM 
DYKCGSPSDS STTEEMEVAV SKARAKVTMN DFDYLKLLGK GTFGKVILVR EKATGRYYAM 
KILRKEVIIA KDEVAHTVTE SRVLQNTRHP FLTALKYAFQ THDRLCFVME YANGGELFFH 
LSRERVFTEE RARFYGAEIV SALEYLHSRD VVYRDIKLEN LMLDKDGHIK ITDFGLCKEG 
ISDGATMKTF CGTPEYLAPE VLEDNDYGRA VDWWGLGVVM YEMMCGRLPF YNQDHERLFE 
LILMEEIRFP RTLSPEAKSL LAGLLKKDPK QRLGGGPSDA KEVMEHRFFL SINWQDVVQK 
KLLPPFKPQV TSEVDTRYFD DEFTAQSITI TPPDRYDSLG LLELDQRTHF PQFSYSASIR 
E

Genular Protein ID: 3904952016

Symbol: B4DG79_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DG79

Database IDs:

Sequence Information:

Length: 419
Mass: 48502
Checksum: 67AEDEBB2CDC2D53
Sequence:

MKTERPRPNT FVIRCLQWTT VIERTFHVDS PDEREEWMRA IQMVANSLKQ RAPGEDPMDY 
KCGSPSDSST TEEMEVAVSK ARAKVTMNDF DYLKLLGKGT FGKVILVREK ATGRYYAMKI 
LRKEVIIAKD EVAHTVTESR VLQNTRHPFL TALKYAFQTH DRLCFVMEYA NGGELFFHLS 
RERVFTEERA RFYGAEIVSA LEYLHSRDVV YRDIKLENLM LDKDGHIKIT DFGLCKEGIS 
DGATMKTFCG TPEYLAPEVL EDNDYGRAVD WWGLGVVMYE MMCGRLPFYN QDHERLFELI 
LMEEIRFPRT LSPEAKSLLA GLLKKDPKQR LGGGPSDAKE VMEHRFFLSI NWQDVVQKKL 
LPPFKPQVTS EVDTRYFDDE FTAQSITITP PDRYDSLGLL ELDQRTHFPQ FSYSASIRE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: AKT2

Associated with

Cells (max top 100)

Other Information

Molecular cloning of a second form of rac protein kinase. PubMed ID: 1801921

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. PubMed ID: 1409633

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha. PubMed ID: 9512493

The protooncogene TCL1 is an Akt kinase coactivator. PubMed ID: 10983986

Activation of a GST-tagged AKT2/PKBbeta. PubMed ID: 15890450

A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda. PubMed ID: 16792529

Kinetic mechanism of AKT/PKB enzyme family. PubMed ID: 16540465

Akt2 is implicated in skeletal muscle differentiation and specifically binds Prohibitin2/REA. PubMed ID: 17565718

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt. PubMed ID: 20059950

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

The E3 ligase TRAF6 regulates Akt ubiquitination and activation. PubMed ID: 19713527

Akt2 and Akt3 play a pivotal role in malignant gliomas. PubMed ID: 20167810

Initial characterization of the human central proteome. PubMed ID: 21269460

Akt signalling in health and disease. PubMed ID: 21620960

Akt1 and Akt2: differentiating the aktion. PubMed ID: 21432781

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis. PubMed ID: 31204173

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation. PubMed ID: 12086620

Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP. PubMed ID: 12434148

Crystal structure of an inactive Akt2 kinase domain. PubMed ID: 12517337

Solution structure and backbone dynamics of the pleckstrin homology domain of the human protein kinase B (PKB/Akt). Interaction with inositol phosphates. PubMed ID: 14755158

A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera. PubMed ID: 17275837

Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. PubMed ID: 18800763

Aminofurazans as potent inhibitors of AKT kinase. PubMed ID: 19179070

A family with severe insulin resistance and diabetes due to a mutation in AKT2. PubMed ID: 15166380

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis. PubMed ID: 19164855

An activating mutation of AKT2 and human hypoglycemia. PubMed ID: 21979934