Details for: AKT2

Gene ID: 208

Symbol: AKT2

Ensembl ID: ENSG00000105221

Description: AKT serine/threonine kinase 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.05
    Marker Score: 8,582
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.67
    Marker Score: 102,782
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.65
    Marker Score: 15,510
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.61
    Marker Score: 34,407
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.6
    Marker Score: 15,214
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.53
    Marker Score: 3,606
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.5
    Marker Score: 439
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.45
    Marker Score: 12,442
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.41
    Marker Score: 52,170
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.4
    Marker Score: 53,074
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.39
    Marker Score: 1,500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.37
    Marker Score: 5,669
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.37
    Marker Score: 20,417
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.35
    Marker Score: 1,366
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.32
    Marker Score: 5,099
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.3
    Marker Score: 1,398
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.3
    Marker Score: 25,772
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.29
    Marker Score: 541
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.27
    Marker Score: 9,717
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.23
    Marker Score: 599
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.23
    Marker Score: 1,898
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.22
    Marker Score: 12,408
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.19
    Marker Score: 4,865
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.19
    Marker Score: 436
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.16
    Marker Score: 676
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.16
    Marker Score: 2,448
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.14
    Marker Score: 7,405
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.14
    Marker Score: 1,307
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.13
    Marker Score: 4,198
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.13
    Marker Score: 17,693
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.11
    Marker Score: 1,095
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.1
    Marker Score: 11,392
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.1
    Marker Score: 301
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.08
    Marker Score: 401
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.04
    Marker Score: 369
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.02
    Marker Score: 1,235
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.02
    Marker Score: 346
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.02
    Marker Score: 612
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.01
    Marker Score: 1,363
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.01
    Marker Score: 1,485
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.01
    Marker Score: 563
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,637
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,862
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.99
    Marker Score: 314
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,381
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.96
    Marker Score: 833
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.96
    Marker Score: 1,006
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.95
    Marker Score: 870
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,386
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.93
    Marker Score: 637
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.93
    Marker Score: 962
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.92
    Marker Score: 540
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 474
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.92
    Marker Score: 260
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9
    Marker Score: 16,034
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,685
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.9
    Marker Score: 493
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.89
    Marker Score: 205
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.89
    Marker Score: 307
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.88
    Marker Score: 276
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.87
    Marker Score: 223
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,292
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.87
    Marker Score: 8,783
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.87
    Marker Score: 5,176
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.87
    Marker Score: 582
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.87
    Marker Score: 1,671
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.87
    Marker Score: 353
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.86
    Marker Score: 7,514
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.86
    Marker Score: 189
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.86
    Marker Score: 1,108
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.86
    Marker Score: 946
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.85
    Marker Score: 1,431
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.85
    Marker Score: 343
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.84
    Marker Score: 2,297
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.84
    Marker Score: 1,852
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.84
    Marker Score: 9,494
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.84
    Marker Score: 3,309
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.84
    Marker Score: 2,494
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.83
    Marker Score: 2,051
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.83
    Marker Score: 977
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.83
    Marker Score: 880
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.83
    Marker Score: 198
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.83
    Marker Score: 3,562
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.83
    Marker Score: 4,709
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.83
    Marker Score: 562
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.83
    Marker Score: 1,097
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.82
    Marker Score: 1,970
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.82
    Marker Score: 2,197
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.82
    Marker Score: 870
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.82
    Marker Score: 2,223
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.82
    Marker Score: 873
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.82
    Marker Score: 926
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 325
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.81
    Marker Score: 1,143
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.81
    Marker Score: 189
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.81
    Marker Score: 199
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.8
    Marker Score: 2,761
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.8
    Marker Score: 542

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Serine/threonine kinase**: AKT2 is a member of the AGC kinase family, which is a group of serine/threonine kinases that play critical roles in various cellular processes. 2. **Phosphorylation-dependent activation**: AKT2 is activated by phosphorylation at specific sites, which triggers the activation of downstream targets. 3. **Dual localization**: AKT2 is localized in both the cytosol and nucleus, where it regulates various cellular processes. 4. **Signaling versatility**: AKT2 is involved in numerous signaling pathways, including those involved in cell survival, proliferation, metabolism, and immune response. **Pathways and Functions** 1. **PI3K/AKT signaling pathway**: AKT2 is a key component of the PI3K/AKT signaling pathway, which regulates cell survival, proliferation, and metabolism. 2. **Apoptosis regulation**: AKT2 is involved in regulating apoptosis, either by promoting cell survival or inhibiting cell death. 3. **Cell cycle regulation**: AKT2 regulates the cell cycle, particularly at the G1/S transition, by phosphorylating and activating downstream targets. 4. **Immune response**: AKT2 is involved in regulating immune responses, including the activation of immune cells and the production of cytokines. 5. **Cancer regulation**: AKT2 is often overexpressed in cancer cells, where it promotes cell survival, proliferation, and metastasis. 6. **Neurotransmission**: AKT2 is involved in regulating neurotransmission, particularly in the central nervous system. **Clinical Significance** 1. **Cancer therapy**: AKT2 is a potential therapeutic target in cancer treatment, as its overexpression is associated with poor prognosis. 2. **Neurodegenerative diseases**: AKT2 is involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Immune disorders**: AKT2 is involved in regulating immune responses, and its dysregulation is associated with immune disorders, such as autoimmune diseases. 4. **Cardiovascular disease**: AKT2 is involved in regulating cardiovascular function, and its dysregulation is associated with cardiovascular disease. 5. **Infectious diseases**: AKT2 is involved in regulating immune responses to infectious diseases, such as HIV and SARS-CoV-2. In conclusion, AKT2 is a critical regulator of various cellular processes, including cell survival, proliferation, metabolism, and immune response. Its dysregulation is associated with various diseases, including cancer, neurodegenerative diseases, immune disorders, cardiovascular disease, and infectious diseases. Further research is needed to fully understand the role of AKT2 in human disease and to develop effective therapeutic strategies.

Genular Protein ID: 1701018404

Symbol: AKT2_HUMAN

Name: RAC-beta serine/threonine-protein kinase

UniProtKB Accession Codes:

P31751 B2RBD8 Q05BV0 Q0VAN0 Q0VAN1 Q68GC0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CPTAC 21 CPTC 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 4 DrugCentral 1 EC 3 ELM 1 EMBL 8 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 43 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 31 PDBsum 18 PIR 1 PRO 1 PROSITE 5 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 31 RefSeq 9 Rhea 6 SABIO-RK 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1801921

Title: Molecular cloning of a second form of rac protein kinase.

PubMed ID: 1801921

DOI: 10.1091/mbc.2.12.1001

PubMed ID: 1409633

Title: AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.

PubMed ID: 1409633

DOI: 10.1073/pnas.89.19.9267

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9512493

Title: Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha.

PubMed ID: 9512493

DOI: 10.1042/bj3310299

PubMed ID: 10983986

Title: The protooncogene TCL1 is an Akt kinase coactivator.

PubMed ID: 10983986

DOI: 10.1016/s1097-2765(00)00039-3

PubMed ID: 15890450

Title: Activation of a GST-tagged AKT2/PKBbeta.

PubMed ID: 15890450

DOI: 10.1016/j.bbagen.2005.04.002

PubMed ID: 16792529

Title: A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda.

PubMed ID: 16792529

DOI: 10.1042/bj20060511

PubMed ID: 16540465

Title: Kinetic mechanism of AKT/PKB enzyme family.

PubMed ID: 16540465

DOI: 10.1074/jbc.m601384200

PubMed ID: 17565718

Title: Akt2 is implicated in skeletal muscle differentiation and specifically binds Prohibitin2/REA.

PubMed ID: 17565718

DOI: 10.1002/jcp.21177

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20059950

Title: The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt.

PubMed ID: 20059950

DOI: 10.1016/j.devcel.2009.09.007

PubMed ID: 19139280

Title: ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization.

PubMed ID: 19139280

DOI: 10.1128/mcb.00754-08

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19713527

Title: The E3 ligase TRAF6 regulates Akt ubiquitination and activation.

PubMed ID: 19713527

DOI: 10.1126/science.1175065

PubMed ID: 20167810

Title: Akt2 and Akt3 play a pivotal role in malignant gliomas.

PubMed ID: 20167810

DOI: 10.1093/neuonc/nop026

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21620960

Title: Akt signalling in health and disease.

PubMed ID: 21620960

DOI: 10.1016/j.cellsig.2011.05.004

PubMed ID: 21432781

Title: Akt1 and Akt2: differentiating the aktion.

PubMed ID: 21432781

DOI: 10.14670/hh-26.651

PubMed ID: 21737686

Title: Ankrd2/ARPP is a novel Akt2 specific substrate and regulates myogenic differentiation upon cellular exposure to H(2)O(2).

PubMed ID: 21737686

DOI: 10.1091/mbc.e10-11-0928

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12086620

Title: Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation.

PubMed ID: 12086620

DOI: 10.1016/s1097-2765(02)00550-6

PubMed ID: 12434148

Title: Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP.

PubMed ID: 12434148

DOI: 10.1038/nsb870

PubMed ID: 12517337

Title: Crystal structure of an inactive Akt2 kinase domain.

PubMed ID: 12517337

DOI: 10.1016/s0969-2126(02)00937-1

PubMed ID: 14755158

Title: Solution structure and backbone dynamics of the pleckstrin homology domain of the human protein kinase B (PKB/Akt). Interaction with inositol phosphates.

PubMed ID: 14755158

DOI: 10.1023/b:jnmr.0000013836.62154.c2

PubMed ID: 31204173

Title: Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis.

PubMed ID: 31204173

DOI: 10.1016/j.devcel.2019.05.022

PubMed ID: 17275837

Title: A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera.

PubMed ID: 17275837

DOI: 10.1016/j.jmb.2007.01.004

PubMed ID: 18800763

Title: Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.

PubMed ID: 18800763

DOI: 10.1021/jm8004527

PubMed ID: 19179070

Title: Aminofurazans as potent inhibitors of AKT kinase.

PubMed ID: 19179070

DOI: 10.1016/j.bmcl.2009.01.002

PubMed ID: 15166380

Title: A family with severe insulin resistance and diabetes due to a mutation in AKT2.

PubMed ID: 15166380

DOI: 10.1126/science.1096706

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 19164855

Title: Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis.

PubMed ID: 19164855

DOI: 10.1172/jci37432

PubMed ID: 21979934

Title: An activating mutation of AKT2 and human hypoglycemia.

PubMed ID: 21979934

DOI: 10.1126/science.1210878

Sequence Information:

  • Length: 481
  • Mass: 55769
  • Checksum: B18C87A7246BFB24
  • Sequence:
    • MNEVSVIKEG WLHKRGEYIK TWRPRYFLLK SDGSFIGYKE RPEAPDQTLP PLNNFSVAEC 
QLMKTERPRP NTFVIRCLQW TTVIERTFHV DSPDEREEWM RAIQMVANSL KQRAPGEDPM 
DYKCGSPSDS STTEEMEVAV SKARAKVTMN DFDYLKLLGK GTFGKVILVR EKATGRYYAM 
KILRKEVIIA KDEVAHTVTE SRVLQNTRHP FLTALKYAFQ THDRLCFVME YANGGELFFH 
LSRERVFTEE RARFYGAEIV SALEYLHSRD VVYRDIKLEN LMLDKDGHIK ITDFGLCKEG 
ISDGATMKTF CGTPEYLAPE VLEDNDYGRA VDWWGLGVVM YEMMCGRLPF YNQDHERLFE 
LILMEEIRFP RTLSPEAKSL LAGLLKKDPK QRLGGGPSDA KEVMEHRFFL SINWQDVVQK 
KLLPPFKPQV TSEVDTRYFD DEFTAQSITI TPPDRYDSLG LLELDQRTHF PQFSYSASIR 
E

Genular Protein ID: 3904952016

Symbol: B4DG79_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DG79

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 11 DNASU 1 EC 2 EMBL 2 GO 4 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 8 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 RefSeq 2 Rhea 6 RuleBase 1 SMART 2 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 419
  • Mass: 48502
  • Checksum: 67AEDEBB2CDC2D53
  • Sequence:
    • MKTERPRPNT FVIRCLQWTT VIERTFHVDS PDEREEWMRA IQMVANSLKQ RAPGEDPMDY 
KCGSPSDSST TEEMEVAVSK ARAKVTMNDF DYLKLLGKGT FGKVILVREK ATGRYYAMKI 
LRKEVIIAKD EVAHTVTESR VLQNTRHPFL TALKYAFQTH DRLCFVMEYA NGGELFFHLS 
RERVFTEERA RFYGAEIVSA LEYLHSRDVV YRDIKLENLM LDKDGHIKIT DFGLCKEGIS 
DGATMKTFCG TPEYLAPEVL EDNDYGRAVD WWGLGVVMYE MMCGRLPFYN QDHERLFELI 
LMEEIRFPRT LSPEAKSLLA GLLKKDPKQR LGGGPSDAKE VMEHRFFLSI NWQDVVQKKL 
LPPFKPQVTS EVDTRYFDDE FTAQSITITP PDRYDSLGLL ELDQRTHFPQ FSYSASIRE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.