Genular: Defining Cellular Identity and Function

Details for: Srf

Gene ID: 20807

Symbol: Srf

Ensembl ID: ENSMUSG00000015605

Description: serum response factor

Associated with

Ngf-stimulated transcription
(R-MMU-9031628)
Nuclear events (kinase and transcription factor activation)
(R-MMU-198725)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate formins
(R-MMU-5663220)
Signaling by ntrk1 (trka)
(R-MMU-187037)
Signaling by ntrks
(R-MMU-166520)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
Actin cytoskeleton organization
(GO:0030036)
Actin filament organization
(GO:0007015)
Associative learning
(GO:0008306)
Axon extension
(GO:0048675)
Branching involved in blood vessel morphogenesis
(GO:0001569)
Cardiac myofibril assembly
(GO:0055003)
Cell-matrix adhesion
(GO:0007160)
Cell migration involved in sprouting angiogenesis
(GO:0002042)
Chromatin binding
(GO:0003682)
Chromatin dna binding
(GO:0031490)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Contractile actin filament bundle assembly
(GO:0030038)
Developmental growth
(GO:0048589)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription factor binding
(GO:0140297)
Dna binding
(GO:0003677)
Dorsal aorta morphogenesis
(GO:0035912)
Epithelial structure maintenance
(GO:0010669)
Erythrocyte development
(GO:0048821)
Filopodium assembly
(GO:0046847)
Forebrain development
(GO:0030900)
Gastrulation
(GO:0007369)
Heart development
(GO:0007507)
Heart looping
(GO:0001947)
Hematopoietic stem cell differentiation
(GO:0060218)
Hippocampus development
(GO:0021766)
Histone deacetylase binding
(GO:0042826)
In utero embryonic development
(GO:0001701)
Leukocyte differentiation
(GO:0002521)
Long-term memory
(GO:0007616)
Megakaryocyte development
(GO:0035855)
Mesoderm formation
(GO:0001707)
Morphogenesis of an epithelial sheet
(GO:0002011)
Multicellular organism development
(GO:0007275)
Muscle cell cellular homeostasis
(GO:0046716)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of cell population proliferation
(GO:0008285)
Neuron migration
(GO:0001764)
Neuron projection development
(GO:0031175)
Platelet activation
(GO:0030168)
Platelet formation
(GO:0030220)
Positive regulation of axon extension
(GO:0045773)
Positive regulation of cell differentiation
(GO:0045597)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of filopodium assembly
(GO:0051491)
Positive regulation of smooth muscle contraction
(GO:0045987)
Positive regulation of transcription by glucose
(GO:0046016)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription initiation by rna polymerase ii
(GO:0060261)
Positive thymic t cell selection
(GO:0045059)
Primary mirna binding
(GO:0070878)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Protein homodimerization activity
(GO:0042803)
Regulation of cell adhesion
(GO:0030155)
Regulation of dna-templated transcription
(GO:0006355)
Response to cytokine
(GO:0034097)
Response to hormone
(GO:0009725)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sarcomere organization
(GO:0045214)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Serum response element binding
(GO:0010736)
Skin morphogenesis
(GO:0043589)
Stress fiber assembly
(GO:0043149)
Tangential migration from the subventricular zone to the olfactory bulb
(GO:0022028)
Thymus development
(GO:0048538)
Thyroid gland development
(GO:0030878)
Transcription by rna polymerase ii
(GO:0006366)
Trophectodermal cell differentiation
(GO:0001829)

Other Information

Proteins

Serum response factor

Genular Protein ID: 2063176104

Symbol: SRF_MOUSE

Name: Serum response factor

UniProtKB Accession Codes:

Q9JM73

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12732141

Title: Actin dynamics control SRF activity by regulation of its coactivator MAL.

PubMed ID: 12732141

DOI: 10.1016/s0092-8674(03)00278-2

PubMed ID: 15492011

Title: Identification of a novel serum response factor cofactor in cardiac gene regulation.

PubMed ID: 15492011

DOI: 10.1074/jbc.m405945200

PubMed ID: 15169892

Title: Targeted inactivation of serum response factor in the developing heart results in myocardial defects and embryonic lethality.

PubMed ID: 15169892

DOI: 10.1128/mcb.24.12.5281-5289.2004

PubMed ID: 16782067

Title: Zipzap/p200 is a novel zinc finger protein contributing to cardiac gene regulation.

PubMed ID: 16782067

DOI: 10.1016/j.bbrc.2006.05.211

PubMed ID: 16597624

Title: Co-activation of atrial natriuretic factor promoter by Tip60 and serum response factor.

PubMed ID: 16597624

DOI: 10.1074/jbc.m513593200

PubMed ID: 16814806

Title: Physical and functional interactions between the prostate suppressor homeoprotein NKX3.1 and serum response factor.

PubMed ID: 16814806

DOI: 10.1016/j.jmb.2006.05.064

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 19350017

Title: SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin.

PubMed ID: 19350017

DOI: 10.1038/ncb1862

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24732378

Title: Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts.

PubMed ID: 24732378

DOI: 10.1101/gad.239327.114

Sequence Information:

Length: 504
Mass: 51247
Checksum: 26353F18A2B46F6B
Sequence:

MLPSQAGAAA ALGRGSALGG NLNRTPTGRP GGGGGTRGAN GGRVPGNGAG LGQSRLEREA 
AAAAAPTAGA LYSGSEGDSE SGEEEELGAE RRGLKRSLSE MELGVVVGGP EAAAAAAGGY 
GPVSGAVSGA KPGKKTRGRV KIKMEFIDNK LRRYTTFSKR KTGIMKKAYE LSTLTGTQVL 
LLVASETGHV YTFATRKLQP MITSETGKAL IQTCLNSPDS PPRSDPTTDQ RMSATGFEEP 
DLTYQVSESD SSGETKDTLK PAFTVTNLPG TTSTIQTAPS TSTTMQVSSG PSFPITNYLA 
PVSASVSPSA VSSANGTVLK STGSGPVSSG GLMQLPTSFT LMPGGAVAQQ VPVQAIHVHQ 
APQQASPSRD SSTDLTQTSS SGTVTLPATI MTSSVPTTVG GHMMYPSPHA VMYAPTSGLA 
DGSLTVLNAF SQAPSTMQVS HSQVQEPGGV PQVFLTAPSG TVQIPVSAVQ LHQMAVIGQQ 
AGSSSNLTEL QVVNLDATHS TKSE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Srf

Associated with

Other Information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Actin dynamics control SRF activity by regulation of its coactivator MAL. PubMed ID: 12732141

Identification of a novel serum response factor cofactor in cardiac gene regulation. PubMed ID: 15492011

Targeted inactivation of serum response factor in the developing heart results in myocardial defects and embryonic lethality. PubMed ID: 15169892

Zipzap/p200 is a novel zinc finger protein contributing to cardiac gene regulation. PubMed ID: 16782067

Co-activation of atrial natriuretic factor promoter by Tip60 and serum response factor. PubMed ID: 16597624

Physical and functional interactions between the prostate suppressor homeoprotein NKX3.1 and serum response factor. PubMed ID: 16814806

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin. PubMed ID: 19350017

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts. PubMed ID: 24732378