Genular: Defining Cellular Identity and Function

Details for: Stat5b

Gene ID: 20851

Symbol: Stat5b

Ensembl ID: ENSMUSG00000020919

Description: signal transducer and activator of transcription 5B

Associated with

Cytokine signaling in immune system
(R-MMU-1280215)
Downstream signal transduction
(R-MMU-186763)
Growth hormone receptor signaling
(R-MMU-982772)
Immune system
(R-MMU-168256)
Interleukin-2 family signaling
(R-MMU-451927)
Interleukin-2 signaling
(R-MMU-9020558)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-MMU-512988)
Interleukin-7 signaling
(R-MMU-1266695)
Interleukin-9 signaling
(R-MMU-8985947)
Interleukin-15 signaling
(R-MMU-8983432)
Interleukin-20 family signaling
(R-MMU-8854691)
Interleukin-21 signaling
(R-MMU-9020958)
Signaling by interleukins
(R-MMU-449147)
Signaling by pdgf
(R-MMU-186797)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by scf-kit
(R-MMU-1433557)
Acute-phase response
(GO:0006953)
B cell differentiation
(GO:0030183)
Cell population proliferation
(GO:0008283)
Cellular response to hormone stimulus
(GO:0032870)
Chromatin binding
(GO:0003682)
Cytokine-mediated signaling pathway
(GO:0019221)
Defense response
(GO:0006952)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription factor binding
(GO:0140297)
Dna binding
(GO:0003677)
Double-stranded dna binding
(GO:0003690)
Erythrocyte differentiation
(GO:0030218)
Female pregnancy
(GO:0007565)
Gamma-delta t cell differentiation
(GO:0042492)
Identical protein binding
(GO:0042802)
Interleukin-2 production
(GO:0032623)
Lactation
(GO:0007595)
Lipid storage
(GO:0019915)
Liver development
(GO:0001889)
Luteinization
(GO:0001553)
Lymphocyte differentiation
(GO:0030098)
Mitotic cell cycle
(GO:0000278)
Myeloid cell apoptotic process
(GO:0033028)
Natural killer cell differentiation
(GO:0001779)
Natural killer cell mediated cytotoxicity
(GO:0042267)
Natural killer cell proliferation
(GO:0001787)
Negative regulation of erythrocyte differentiation
(GO:0045647)
Negative regulation of myeloid cell apoptotic process
(GO:0033033)
Nuclear glucocorticoid receptor binding
(GO:0035259)
Positive regulation of activated t cell proliferation
(GO:0042104)
Positive regulation of b cell differentiation
(GO:0045579)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of erythrocyte differentiation
(GO:0045648)
Positive regulation of gamma-delta t cell differentiation
(GO:0045588)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of interleukin-2 production
(GO:0032743)
Positive regulation of lymphocyte differentiation
(GO:0045621)
Positive regulation of mitotic cell cycle
(GO:0045931)
Positive regulation of multicellular organism growth
(GO:0040018)
Positive regulation of natural killer cell differentiation
(GO:0032825)
Positive regulation of natural killer cell mediated cytotoxicity
(GO:0045954)
Positive regulation of natural killer cell proliferation
(GO:0032819)
Positive regulation of smooth muscle cell migration
(GO:0014911)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Progesterone metabolic process
(GO:0042448)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Protein homodimerization activity
(GO:0042803)
Receptor signaling pathway via jak-stat
(GO:0007259)
Regulation of cell adhesion
(GO:0030155)
Regulation of cell population proliferation
(GO:0042127)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of epithelial cell differentiation
(GO:0030856)
Regulation of multicellular organism growth
(GO:0040014)
Regulation of steroid metabolic process
(GO:0019218)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to estradiol
(GO:0032355)
Response to lipopolysaccharide
(GO:0032496)
Response to peptide hormone
(GO:0043434)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Sex differentiation
(GO:0007548)
Signal transduction
(GO:0007165)
Taurine metabolic process
(GO:0019530)
T cell differentiation in thymus
(GO:0033077)
T cell homeostasis
(GO:0043029)
Transcription by rna polymerase ii
(GO:0006366)

Other Information

Proteins

Signal transducer and activator of transcription 5B

Genular Protein ID: 407737895

Symbol: STA5B_MOUSE

Name: Signal transducer and activator of transcription 5B

UniProtKB Accession Codes:

P42232 A2A5D5 Q541Q5 Q60804 Q8K3Q1 Q9JKM1 Q9R0X8

Database IDs:

Citations:

PubMed ID: 7720707

Title: Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.

PubMed ID: 7720707

DOI: 10.1002/j.1460-2075.1995.tb07100.x

PubMed ID: 7568026

Title: Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue.

PubMed ID: 7568026

DOI: 10.1073/pnas.92.19.8831

PubMed ID: 11161808

Title: Structure of the mouse Stat 3/5 locus: evolution from Drosophila to zebrafish to mouse.

PubMed ID: 11161808

DOI: 10.1006/geno.2000.6433

PubMed ID: 14701862

Title: A mutant Stat5b with weaker DNA binding affinity defines a key defective pathway in non-obese diabetic (NOD) mice.

PubMed ID: 14701862

DOI: 10.1074/jbc.m312110200

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10835485

Title: Molecular characterization of STAT5A- and STAT5B-encoding genes reveals extended intragenic sequence homogeneity in cattle and mouse and different degrees of divergent evolution of various domains.

PubMed ID: 10835485

DOI: 10.1007/s002390010058

PubMed ID: 9428692

Title: Identification of Stat 5B as a substrate of the insulin receptor.

PubMed ID: 9428692

DOI: 10.1111/j.1432-1033.1997.0411a.x

PubMed ID: 9528750

Title: Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocortiocoid receptor in mammary cells.

PubMed ID: 9528750

DOI: 10.1128/mcb.18.4.1783

PubMed ID: 11090077

Title: Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways.

PubMed ID: 11090077

PubMed ID: 11773439

Title: A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus.

PubMed ID: 11773439

DOI: 10.1210/mend.16.1.0761

PubMed ID: 24319783

Title: Retraction.

PubMed ID: 24319783

DOI: 10.1210/me.2013-1264

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20639532

Title: A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neurons.

PubMed ID: 20639532

DOI: 10.1093/nar/gkq634

PubMed ID: 21135090

Title: Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells.

PubMed ID: 21135090

DOI: 10.1074/jbc.m110.182642

PubMed ID: 21262971

Title: Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.

PubMed ID: 21262971

DOI: 10.1074/jbc.m110.205021

Sequence Information:

Length: 786
Mass: 90002
Checksum: A8FE76405E41B2EF
Sequence:

MAMWIQAQQL QGDALHQMQA LYGQHFPIEV RHYLSQWIES QAWDSIDLDN PQENIKATQL 
LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQSTYDR CPMELVRCIR HILYNEQRLV 
REANNGSSPA GSLADAMSQK HLQINQTFEE LRLITQDTEN ELKKLQQTQE YFIIQYQESL 
RIQAQFAQLG QLNPQERMSR ETALQQKQVS LETWLQREAQ TLQQYRVELA EKHQKTLQLL 
RKQQTIILDD ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC 
QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL 
NVHMNPPQVK ATIISEQQAK SLLKNENTRN DYSGEILNNC CVMEYHQATG TLSAHFRNMS 
LKRIKRSDRR GAESVTEEKF TILFDSQFSV GGNELVFQVK TLSLPVVVIV HGSQDNNATA 
TVLWDNAFAE PGRVPFAVPD KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNI 
SSNHLEDYNS MSVSWSQFNR ENLPGRNYTF WQWFDGVMEV LKKHLKPHWN DGAILGFVNK 
QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSQERMF WNLMPFTTRD FSIRSLADRL 
GDLNYLIYVF PDRPKDEVYS KYYTPVPCEP ATAKAADGYV KPQIKQVVPE FANASTDAGS 
GATYMDQAPS PVVCPQAHYN MYPPNPDSVL DTDGDFDLED TMDVARRVEE LLGRPMDSQW 
IPHAQS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Stat5b

Associated with

Other Information

Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. PubMed ID: 7720707

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue. PubMed ID: 7568026

Structure of the mouse Stat 3/5 locus: evolution from Drosophila to zebrafish to mouse. PubMed ID: 11161808

A mutant Stat5b with weaker DNA binding affinity defines a key defective pathway in non-obese diabetic (NOD) mice. PubMed ID: 14701862

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular characterization of STAT5A- and STAT5B-encoding genes reveals extended intragenic sequence homogeneity in cattle and mouse and different degrees of divergent evolution of various domains. PubMed ID: 10835485

Identification of Stat 5B as a substrate of the insulin receptor. PubMed ID: 9428692

Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocortiocoid receptor in mammary cells. PubMed ID: 9528750

Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways. PubMed ID: 11090077

A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus. PubMed ID: 11773439

Retraction. PubMed ID: 24319783

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neurons. PubMed ID: 20639532

Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells. PubMed ID: 21135090

Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling. PubMed ID: 21262971