Genular: Defining Cellular Identity and Function

Details for: Stat6

Gene ID: 20852

Symbol: Stat6

Ensembl ID: ENSMUSG00000002147

Description: signal transducer and activator of transcription 6

Associated with

Cytokine signaling in immune system
(R-MMU-1280215)
Cytosolic sensors of pathogen-associated dna
(R-MMU-1834949)
Downstream signal transduction
(R-MMU-186763)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-4 and interleukin-13 signaling
(R-MMU-6785807)
Signaling by interleukins
(R-MMU-449147)
Signaling by pdgf
(R-MMU-186797)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Stat6-mediated induction of chemokines
(R-MMU-3249367)
Sting mediated induction of host immune responses
(R-MMU-1834941)
Cellular response to hydrogen peroxide
(GO:0070301)
Cellular response to reactive nitrogen species
(GO:1902170)
Chromatin
(GO:0000785)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response
(GO:0006952)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Gene expression
(GO:0010467)
Growth hormone receptor signaling pathway via jak-stat
(GO:0060397)
Identical protein binding
(GO:0042802)
Interleukin-4-mediated signaling pathway
(GO:0035771)
Isotype switching to ige isotypes
(GO:0048289)
Mammary gland epithelial cell proliferation
(GO:0033598)
Mammary gland morphogenesis
(GO:0060443)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of type 2 immune response
(GO:0002829)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of isotype switching to ige isotypes
(GO:0048295)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein phosphatase binding
(GO:0019903)
Receptor signaling pathway via jak-stat
(GO:0007259)
Regulation of cell population proliferation
(GO:0042127)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of mast cell proliferation
(GO:0070666)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to cytokine
(GO:0034097)
Response to peptide hormone
(GO:0043434)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Signal transduction
(GO:0007165)
T-helper 1 cell lineage commitment
(GO:0002296)
Transcription coactivator binding
(GO:0001223)

Other Information

Proteins

Signal transducer and transcription activator 6

Genular Protein ID: 2289317310

Symbol: STAT6_MOUSE

Name: Signal transducer and transcription activator 6

UniProtKB Accession Codes:

P52633 Q8R2F1

Database IDs:

Citations:

PubMed ID: 7760829

Title: Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis.

PubMed ID: 7760829

DOI: 10.1128/mcb.15.6.3336

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17210636

Title: T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6.

PubMed ID: 17210636

DOI: 10.1128/mcb.01234-06

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 837
Mass: 93497
Checksum: 082E0A15C7457307
Sequence:

MSLWGLISKM SPEKLQRLYV DFPQRLRHLL ADWLESQPWE FLVGSDAFCY NMASALLSAT 
VQRLQATAGE QGKGNSILPH ISTLESIYQR DPLKLVATIR QILQGEKKAV IEEFRHLPGP 
FHRKQEELKF TTALGRLQHR VRETRLLRES LQQGAKTGQV SLQNLIDPPV NGPGPSEDLA 
TMLQGTVGDL EATQALVLKR IQIWKRQQQL AGNGTPFEES LAGLQERCES LVEIYSQLQQ 
EIGAASGELE PKTRASLISR LDEVLRTLVT SSFLVEKQPP QVLKTQTKFQ AGVRFLLGLQ 
FLGTSAKPPM VRADMVTEKQ ARELSLAQGP GTGVESTGEI MNNTVPLENS IPSNCCSALF 
KNLLLKKIKR CERKGTESVT EEKCAVLFST SFTLGPNKLL IQLQALSLPL VVIVHGNQDN 
NAKATILWDN AFSEMDRVPF VVAERVPWEK MCETLNLKFM AEVGTSRGLL PEHFLFLAQK 
IFNDNSLSVE AFQHRCVSWS QFNKEILLGR GFTFWQWFDG VLDLTKRCLR SYWSDRLIIG 
FISKQYVTSL LLNEPDGTFL LRFSDSEIGG ITIAHVIRGQ DGSSQIENIQ PFSAKDLSIR 
SLGDRIRDLA QLKNLYPKKP KDEAFRSHYK PEQMGKDGRG YVSTTIKMTV ERDQPLPTPE 
PQMPAMVPPY DLGMAPDASM QLSSDMGYPP QSIHSFQSLE ESMSVLPSFQ EPHLQMPPNM 
SQITMPFDQP HPQGLLQCQS QEHAVSSPEP MLCSDVTMVE DSCLTQPVGG FPQGTWVSED 
MYPPLMPPTE QDLTKLLLEN QGEAGGSLGS QPLLQPSPYG QSGISLSHLD LRTNPSW

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Stat6

Associated with

Other Information

Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. PubMed ID: 7760829

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334