Genular: Defining Cellular Identity and Function

Details for: Stk11

Gene ID: 20869

Symbol: Stk11

Ensembl ID: ENSMUSG00000003068

Description: serine/threonine kinase 11

Associated with

Energy dependent regulation of mtor by lkb1-ampk
(R-MMU-380972)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Mtor signalling
(R-MMU-165159)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 activity through phosphorylation
(R-MMU-6804756)
Rna polymerase ii transcription
(R-MMU-73857)
Transcriptional regulation by tp53
(R-MMU-3700989)
Activation of protein kinase activity
(GO:0032147)
Anoikis
(GO:0043276)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Autophagy
(GO:0006914)
Axonogenesis
(GO:0007409)
Cell cycle
(GO:0007049)
Cell differentiation
(GO:0030154)
Cellular response to uv-b
(GO:0071493)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dendrite extension
(GO:0097484)
Dna damage response
(GO:0006974)
Epithelial cell proliferation involved in prostate gland development
(GO:0060767)
Establishment of cell polarity
(GO:0030010)
G1 to g0 transition
(GO:0070314)
Glucose homeostasis
(GO:0042593)
Golgi localization
(GO:0051645)
Intracellular protein-containing complex
(GO:0140535)
Intrinsic apoptotic signaling pathway by p53 class mediator
(GO:0072332)
Kinase activity
(GO:0016301)
Lrr domain binding
(GO:0030275)
Magnesium ion binding
(GO:0000287)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Mitochondrion
(GO:0005739)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of cold-induced thermogenesis
(GO:0120163)
Negative regulation of epithelial cell proliferation involved in prostate gland development
(GO:0060770)
Negative regulation of torc1 signaling
(GO:1904262)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
P53 binding
(GO:0002039)
Peptidyl-threonine phosphorylation
(GO:0018107)
Phosphorylation
(GO:0016310)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of axonogenesis
(GO:0050772)
Positive regulation of gluconeogenesis
(GO:0045722)
Positive regulation of protein localization to nucleus
(GO:1900182)
Positive regulation of transforming growth factor beta receptor signaling pathway
(GO:0030511)
Positive regulation of vesicle transport along microtubule
(GO:1901610)
Positive thymic t cell selection
(GO:0045059)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein dephosphorylation
(GO:0006470)
Protein kinase activator activity
(GO:0030295)
Protein kinase activity
(GO:0004672)
Protein localization to nucleus
(GO:0034504)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of cell growth
(GO:0001558)
Regulation of dendrite morphogenesis
(GO:0048814)
Regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051896)
Regulation of wnt signaling pathway
(GO:0030111)
Response to ionizing radiation
(GO:0010212)
Response to lipid
(GO:0033993)
Serine/threonine protein kinase complex
(GO:1902554)
Signal transduction
(GO:0007165)
Spermatid development
(GO:0007286)
Spermatogenesis
(GO:0007283)
T cell receptor signaling pathway
(GO:0050852)
Tissue homeostasis
(GO:0001894)
Transferase activity
(GO:0016740)
Vasculature development
(GO:0001944)
Z disc
(GO:0030018)

Other Information

Proteins

Liver kinase B1 homolog
Q3V4A1_MOUSE

Genular Protein ID: 3453806698

Symbol: STK11_MOUSE

Name: Liver kinase B1 homolog

UniProtKB Accession Codes:

Q9WTK7 A0A2L1DGD8 B3VBP0 Q3TAE0

Database IDs:

Citations:

PubMed ID: 10381580

Title: Expression of LKB1 and PTEN tumor suppressor genes during mouse embryonic development.

PubMed ID: 10381580

DOI: 10.1016/s0925-4773(99)00050-7

PubMed ID: 10400995

Title: The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase.

PubMed ID: 10400995

DOI: 10.1093/hmg/8.8.1479

PubMed ID: 10642527

Title: LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo.

PubMed ID: 10642527

DOI: 10.1042/bj3450673

PubMed ID: 12060709

Title: Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis.

PubMed ID: 12060709

DOI: 10.1073/pnas.122254599

PubMed ID: 29777910

Title: Differentially expressed novel alternatively spliced transcript variant of tumor suppressor Stk11 gene in mouse.

PubMed ID: 29777910

DOI: 10.1016/j.gene.2018.05.053

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11297520

Title: Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.

PubMed ID: 11297520

DOI: 10.1074/jbc.m009953200

PubMed ID: 11509733

Title: Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice.

PubMed ID: 11509733

DOI: 10.1126/science.1062074

PubMed ID: 11853558

Title: Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome.

PubMed ID: 11853558

DOI: 10.1042/0264-6021:3620481

PubMed ID: 12234250

Title: Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.

PubMed ID: 12234250

DOI: 10.1042/bj20021284

PubMed ID: 11956081

Title: Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice.

PubMed ID: 11956081

PubMed ID: 12226664

Title: Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation.

PubMed ID: 12226664

DOI: 10.1038/nature01045

PubMed ID: 12218179

Title: Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis.

PubMed ID: 12218179

DOI: 10.1073/pnas.192301399

PubMed ID: 15480979

Title: Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2.

PubMed ID: 15480979

DOI: 10.1053/j.gastro.2004.07.059

PubMed ID: 15345747

Title: Phosphoproteomic analysis of the developing mouse brain.

PubMed ID: 15345747

DOI: 10.1074/mcp.m400085-mcp200

PubMed ID: 16308421

Title: The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.

PubMed ID: 16308421

DOI: 10.1126/science.1120781

PubMed ID: 17482548

Title: LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons.

PubMed ID: 17482548

DOI: 10.1016/j.cell.2007.03.025

PubMed ID: 17482549

Title: LKB1/STRAD promotes axon initiation during neuronal polarization.

PubMed ID: 17482549

DOI: 10.1016/j.cell.2007.04.012

PubMed ID: 18774945

Title: A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis.

PubMed ID: 18774945

DOI: 10.1042/bj20081447

PubMed ID: 18687677

Title: SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation.

PubMed ID: 18687677

DOI: 10.1074/jbc.m805711200

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 18854309

Title: Characterization of an alternative splice variant of LKB1.

PubMed ID: 18854309

DOI: 10.1074/jbc.m806153200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20864035

Title: AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling.

PubMed ID: 20864035

DOI: 10.1016/j.molcel.2010.08.019

PubMed ID: 25329316

Title: A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation.

PubMed ID: 25329316

DOI: 10.1371/journal.pgen.1004721

Sequence Information:

Length: 436
Mass: 49267
Checksum: CCD9BCF94CF5CC9C
Sequence:

MDVADPEPLG LFSEGELMSV GMDTFIHRID STEVIYQPRR KRAKLIGKYL MGDLLGEGSY 
GKVKEVLDSE TLCRRAVKIL KKKKLRRIPN GEANVKKEIQ LLRRLRHRNV IQLVDVLYNE 
EKQKMYMVME YCVCGMQEML DSVPEKRFPV CQAHGYFRQL IDGLEYLHSQ GIVHKDIKPG 
NLLLTTNGTL KISDLGVAEA LHPFAVDDTC RTSQGSPAFQ PPEIANGLDT FSGFKVDIWS 
AGVTLYNITT GLYPFEGDNI YKLFENIGRG DFTIPCDCGP PLSDLLRGML EYEPAKRFSI 
RQIRQHSWFR KKHPLAEALV PIPPSPDTKD RWRSMTVVPY LEDLHGRAEE EEEEDLFDIE 
DGIIYTQDFT VPGQVLEEEV GQNGQSHSLP KAVCVNGTEP QLSSKVKPEG RPGTANPARK 
VCSSNKIRRL SACKQQ

Genular Protein ID: 2254878235

Symbol: Q3V4A1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3V4A1

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 310
Mass: 34556
Checksum: 5E4E458FD627D571
Sequence:

MVMEYCVCGM QEMLDSVPEK RFPVCQAHGY FRQLIDGLEY LHSQGIVHKD IKPGNLLLTT 
NGTLKISDLG VAEALHPFAV DDTCRTSQGS PAFQPPEIAN GLDTFSGFKV DIWSAGVTLY 
NITTGLYPFE GDNIYKLFEN IGRGDFTIPC DCGPPLSDLL RGMLEYEPAK RFSIRQIRQH 
SWFRKKHPLA EALVPIPPSP DTKDRWRSMT VVPYLEDLHG LAEEEEEEDL FDIEDGIIYT 
QDFTVPGQVL EEEVGQNGQS HSLPKAVCVN GTEPQLSSKV KPEGQPGTAN PARKVCSSNK 
IRRLSACKQQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Stk11

Associated with

Other Information

Expression of LKB1 and PTEN tumor suppressor genes during mouse embryonic development. PubMed ID: 10381580

The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase. PubMed ID: 10400995

LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo. PubMed ID: 10642527

Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis. PubMed ID: 12060709

Differentially expressed novel alternatively spliced transcript variant of tumor suppressor Stk11 gene in mouse. PubMed ID: 29777910

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth. PubMed ID: 11297520

Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. PubMed ID: 11509733

Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome. PubMed ID: 11853558

Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. PubMed ID: 12234250

Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice. PubMed ID: 11956081

Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. PubMed ID: 12226664

Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis. PubMed ID: 12218179

Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2. PubMed ID: 15480979

Phosphoproteomic analysis of the developing mouse brain. PubMed ID: 15345747

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. PubMed ID: 16308421

LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons. PubMed ID: 17482548

LKB1/STRAD promotes axon initiation during neuronal polarization. PubMed ID: 17482549

A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis. PubMed ID: 18774945

SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. PubMed ID: 18687677

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

Characterization of an alternative splice variant of LKB1. PubMed ID: 18854309

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling. PubMed ID: 20864035

A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation. PubMed ID: 25329316

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073