Genular: Defining Cellular Identity and Function

Details for: Plk4

Gene ID: 20873

Symbol: Plk4

Ensembl ID: ENSMUSG00000025758

Description: polo like kinase 4

Associated with

Anchoring of the basal body to the plasma membrane
(R-MMU-5620912)
Aurka activation by tpx2
(R-MMU-8854518)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Centrosome maturation
(R-MMU-380287)
G2/m transition
(R-MMU-69275)
Loss of nlp from mitotic centrosomes
(R-MMU-380259)
Loss of proteins required for interphase microtubule organization from the centrosome
(R-MMU-380284)
Mitotic g2-g2/m phases
(R-MMU-453274)
Mitotic prometaphase
(R-MMU-68877)
M phase
(R-MMU-68886)
Organelle biogenesis and maintenance
(R-MMU-1852241)
Recruitment of mitotic centrosome proteins and complexes
(R-MMU-380270)
Recruitment of numa to mitotic centrosomes
(R-MMU-380320)
Regulation of plk1 activity at g2/m transition
(R-MMU-2565942)
Atp binding
(GO:0005524)
Centriole
(GO:0005814)
Centriole replication
(GO:0007099)
Centrosome
(GO:0005813)
Cilium assembly
(GO:0060271)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
De novo centriole assembly involved in multi-ciliated epithelial cell differentiation
(GO:0098535)
Deuterosome
(GO:0098536)
Identical protein binding
(GO:0042802)
Kinase activity
(GO:0016301)
Nucleolus
(GO:0005730)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Phosphorylation
(GO:0016310)
Positive regulation of centriole replication
(GO:0046601)
Procentriole
(GO:0120098)
Procentriole replication complex
(GO:0120099)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Transferase activity
(GO:0016740)
Trophoblast giant cell differentiation
(GO:0060707)
Xy body
(GO:0001741)

Other Information

Proteins

Polo-like kinase 4

Genular Protein ID: 2972897427

Symbol: PLK4_MOUSE

Name: Polo-like kinase 4

UniProtKB Accession Codes:

Q64702 Q3UVA3 Q6PEP6 Q78EG6 Q80UT6 Q8R0I5 Q9CVR6 Q9CVU6

Database IDs:

Citations:

PubMed ID: 8022793

Title: Sak, a murine protein-serine/threonine kinase that is related to the Drosophila polo kinase and involved in cell proliferation.

PubMed ID: 8022793

DOI: 10.1073/pnas.91.14.6388

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8756623

Title: Constitutive expression of murine Sak-a suppresses cell growth and induces multinucleation.

PubMed ID: 8756623

DOI: 10.1128/mcb.16.9.4665

PubMed ID: 11301255

Title: Late mitotic failure in mice lacking Sak, a polo-like kinase.

PubMed ID: 11301255

DOI: 10.1016/s0960-9822(01)00117-8

PubMed ID: 16025114

Title: Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis.

PubMed ID: 16025114

DOI: 10.1038/ng1605

PubMed ID: 17891141

Title: Nucleolar release of Hand1 acts as a molecular switch to determine cell fate.

PubMed ID: 17891141

DOI: 10.1038/ncb1633

PubMed ID: 24240477

Title: The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis.

PubMed ID: 24240477

DOI: 10.1038/ncb2880

PubMed ID: 12352953

Title: The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization.

PubMed ID: 12352953

DOI: 10.1038/nsb848

Sequence Information:

Length: 925
Mass: 103746
Checksum: F28A64ED24D9C801
Sequence:

MAACIGERIE DFKVGNLLGK GSFAGVYRAE SIHTGLEVAI KMIDKKAMYK AGMVQRVQNE 
VKIHCQLKHP SVLELYNYFE DNNYVYLVLE MCHNGEMNRY LKNRMKPFSE REARHFMHQI 
ITGMLYLHSH GILHRDLTLS NILLTRNMNI KIADFGLATQ LNMPHEKHYT LCGTPNYISP 
EIATRSAHGL ESDIWSLGCM FYTLLIGRPP FDTDTVKNTL NKVVLADYEM PAFLSREAQD 
LIHQLLRRNP ADRLSLSSVL DHPFMSRNPS PKSKDVGTVE DSMDSGHATL STTITASSGT 
SLSGSLLDRR LLVGQPLPNK ITVFQKNKNS SDFSSGDGSN FCTQWGNPEQ EANSRGRGRV 
IEDAEERPHS RYLRRAHSSD RASPSNQSRA KTYSVERCHS VEMLSKPRRS LDENQHSSNH 
HCLGKTPFPF ADQTPQMEMV QQWFGNLQMN AHLGETNEHH TVSPNRDFQD YPDLQDTLRN 
AWTDTRASKN ADTSANVHAV KQLSAMKYMS AHHHKPEVMP QEPGLHPHSE QSKNRSMEST 
LGYQKPTLRS ITSPLIAHRL KPIRQKTKKA VVSILDSEEV CVELLRECAS EGYVKEVLQI 
SSDGTMITVY YPNDGRGFPL ADRPPLPTDN ISRYSFDNLP EKYWRKYQYA SRFIQLVRSK 
TPKITYFTRY AKCILMENSP GADFEVWFYD GAKIHKTENL IHIIEKTGIS YNLKNENEVT 
SLKEEVKVYM DHANEGHRIC LSLESVISEE EKRSRGSSFF PIIVGRKPGN TSSPKALSAP 
PVDPSCCKGE QASASRLSVN SAAFPTQSPG LSPSTVTVEG LGHTATATGT GVSSSLPKSA 
QLLKSVFVKN VGWATQLTSG AVWVQFNDGS QLVVQAGVSS ISYTSPDGQT TRYGENEKLP 
EYIKQKLQCL SSILLMFSNP TPNFQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Plk4

Associated with

Other Information

Sak, a murine protein-serine/threonine kinase that is related to the Drosophila polo kinase and involved in cell proliferation. PubMed ID: 8022793

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Constitutive expression of murine Sak-a suppresses cell growth and induces multinucleation. PubMed ID: 8756623

Late mitotic failure in mice lacking Sak, a polo-like kinase. PubMed ID: 11301255

Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis. PubMed ID: 16025114

Nucleolar release of Hand1 acts as a molecular switch to determine cell fate. PubMed ID: 17891141

The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis. PubMed ID: 24240477

The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization. PubMed ID: 12352953