Genular: Defining Cellular Identity and Function

Details for: Aurkb

Gene ID: 20877

Symbol: Aurkb

Ensembl ID: ENSMUSG00000020897

Description: aurora kinase B

Associated with

Amplification of signal from the kinetochores
(R-MMU-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-MMU-141444)
Apc/c-mediated degradation of cell cycle proteins
(R-MMU-174143)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-MMU-174178)
Cell cycle, mitotic
(R-MMU-69278)
Cell cycle checkpoints
(R-MMU-69620)
Eml4 and nudc in mitotic spindle formation
(R-MMU-9648025)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Metabolism of proteins
(R-MMU-392499)
Mitotic anaphase
(R-MMU-68882)
Mitotic metaphase and anaphase
(R-MMU-2555396)
Mitotic prometaphase
(R-MMU-68877)
Mitotic spindle checkpoint
(R-MMU-69618)
M phase
(R-MMU-68886)
Regulation of mitotic cell cycle
(R-MMU-453276)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 activity through phosphorylation
(R-MMU-6804756)
Resolution of sister chromatid cohesion
(R-MMU-2500257)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate formins
(R-MMU-5663220)
Rna polymerase ii transcription
(R-MMU-73857)
Separation of sister chromatids
(R-MMU-2467813)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of dna replication proteins
(R-MMU-4615885)
Transcriptional regulation by tp53
(R-MMU-3700989)
Atp binding
(GO:0005524)
Cell cycle
(GO:0007049)
Cell cycle g2/m phase transition
(GO:0044839)
Cell division
(GO:0051301)
Cellular response to uv
(GO:0034644)
Chromocenter
(GO:0010369)
Chromosome
(GO:0005694)
Chromosome, centromeric region
(GO:0000775)
Chromosome passenger complex
(GO:0032133)
Cleavage furrow formation
(GO:0036089)
Condensed chromosome, centromeric region
(GO:0000779)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Histone h3s28 kinase activity
(GO:0044022)
Kinase activity
(GO:0016301)
Kinase binding
(GO:0019900)
Kinetochore
(GO:0000776)
Microtubule cytoskeleton
(GO:0015630)
Midbody
(GO:0030496)
Mitotic cell cycle
(GO:0000278)
Mitotic cytokinesis
(GO:0000281)
Mitotic spindle midzone
(GO:1990023)
Mitotic spindle midzone assembly
(GO:0051256)
Mitotic spindle organization
(GO:0007052)
Mitotic spindle pole
(GO:0097431)
Negative regulation of b cell apoptotic process
(GO:0002903)
Negative regulation of cgas/sting signaling pathway
(GO:0160049)
Negative regulation of innate immune response
(GO:0045824)
Negative regulation of protein binding
(GO:0032091)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Phosphorylation
(GO:0016310)
Positive regulation of attachment of mitotic spindle microtubules to kinetochore
(GO:1902425)
Positive regulation of cytokinesis
(GO:0032467)
Positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore
(GO:1905116)
Positive regulation of mitotic cell cycle spindle assembly checkpoint
(GO:0090267)
Positive regulation of mitotic cytokinesis
(GO:1903490)
Positive regulation of mitotic sister chromatid segregation
(GO:0062033)
Positive regulation of mitotic sister chromatid separation
(GO:1901970)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of telomerase activity
(GO:0051973)
Positive regulation of telomere capping
(GO:1904355)
Positive regulation of telomere maintenance via telomerase
(GO:0032212)
Post-translational protein modification
(GO:0043687)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein localization to kinetochore
(GO:0034501)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of cytokinesis
(GO:0032465)
Spindle microtubule
(GO:0005876)
Spindle midzone
(GO:0051233)
Spindle organization
(GO:0007051)
Spindle pole centrosome
(GO:0031616)
Transferase activity
(GO:0016740)

Other Information

Proteins

Aurora 1

Genular Protein ID: 2376038583

Symbol: AURKB_MOUSE

Name: Aurora 1

UniProtKB Accession Codes:

O70126 Q61882 Q8C6C1

Database IDs:

Citations:

PubMed ID: 8647446

Title: Cell-cycle-dependent expression of the STK-1 gene encoding a novel murine putative protein kinase.

PubMed ID: 8647446

DOI: 10.1016/0378-1119(95)00809-8

PubMed ID: 9514916

Title: cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2.

PubMed ID: 9514916

DOI: 10.1006/bbrc.1998.8250

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11784863

Title: Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases.

PubMed ID: 11784863

DOI: 10.1128/mcb.22.3.874-885.2002

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24034696

Title: The Aurora B kinase and the Polycomb protein Ring1B combine to regulate active promoters in quiescent lymphocytes.

PubMed ID: 24034696

DOI: 10.1016/j.molcel.2013.08.022

PubMed ID: 29518391

Title: Regulation of keratin 5/14 intermediate filaments by CDK1, Aurora-B, and Rho-kinase.

PubMed ID: 29518391

DOI: 10.1016/j.bbrc.2018.03.016

Sequence Information:

Length: 345
Mass: 39384
Checksum: D204D8B91CFF00A4
Sequence:

MAQKENAYPW PYGSKTSQSG LNTLSQRVLR KEPATTSALA LVNRFNSQST AAPGQKLAEN 
KSQGSTASQG SQNKQPFTID NFEIGRPLGK GKFGNVYLAR EKKSRFIVAL KILFKSQIEK 
EGVEHQLRRE IEIQAHLKHP NILQLYNYFY DQQRIYLILE YAPRGELYKE LQKSRTFDEQ 
RTATIMEELS DALTYCHKKK VIHRDIKPEN LLLGLQGELK IADFGWSVHA PSLRRKTMCG 
TLDYLPPEMI EGRMHNEMVD LWCIGVLCYE LMVGNPPFES PSHSETYRRI VKVDLKFPSS 
VPSGAQDLIS KLLKHNPWQR LPLAEVAAHP WVRANSRRVL PPSAL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Aurkb

Associated with

Other Information

Cell-cycle-dependent expression of the STK-1 gene encoding a novel murine putative protein kinase. PubMed ID: 8647446

cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2. PubMed ID: 9514916

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases. PubMed ID: 11784863

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The Aurora B kinase and the Polycomb protein Ring1B combine to regulate active promoters in quiescent lymphocytes. PubMed ID: 24034696

Regulation of keratin 5/14 intermediate filaments by CDK1, Aurora-B, and Rho-kinase. PubMed ID: 29518391