Genular: Defining Cellular Identity and Function

Details for: Aurka

Gene ID: 20878

Symbol: Aurka

Ensembl ID: ENSMUSG00000027496

Description: aurora kinase A

Associated with

Apc/c-mediated degradation of cell cycle proteins
(R-MMU-174143)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-MMU-174178)
Aurka activation by tpx2
(R-MMU-8854518)
Cell cycle, mitotic
(R-MMU-69278)
Fbxl7 down-regulates aurka during mitotic entry and in early mitosis
(R-MMU-8854050)
G2/m transition
(R-MMU-69275)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Interaction between phlda1 and aurka
(R-MMU-8854521)
Mitotic g2-g2/m phases
(R-MMU-453274)
Regulation of mitotic cell cycle
(R-MMU-453276)
Regulation of plk1 activity at g2/m transition
(R-MMU-2565942)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 activity through phosphorylation
(R-MMU-6804756)
Rna polymerase ii transcription
(R-MMU-73857)
Tp53 regulates transcription of cell cycle genes
(R-MMU-6791312)
Tp53 regulates transcription of genes involved in g2 cell cycle arrest
(R-MMU-6804114)
Transcriptional regulation by tp53
(R-MMU-3700989)
Anterior/posterior axis specification
(GO:0009948)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Axon hillock
(GO:0043203)
Cell cycle
(GO:0007049)
Cell division
(GO:0051301)
Cell projection
(GO:0042995)
Cell projection organization
(GO:0030030)
Centrosome
(GO:0005813)
Centrosome cycle
(GO:0007098)
Centrosome localization
(GO:0051642)
Chromosome passenger complex
(GO:0032133)
Ciliary basal body
(GO:0036064)
Cilium
(GO:0005929)
Cilium disassembly
(GO:0061523)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Germinal vesicle
(GO:0042585)
Glutamatergic synapse
(GO:0098978)
Histone h3s10 kinase activity
(GO:0035175)
Kinase activity
(GO:0016301)
Kinetochore
(GO:0000776)
Liver regeneration
(GO:0097421)
Meiotic cell cycle
(GO:0051321)
Meiotic spindle
(GO:0072687)
Meiotic spindle organization
(GO:0000212)
Membrane
(GO:0016020)
Microtubule
(GO:0005874)
Microtubule cytoskeleton
(GO:0015630)
Microtubule cytoskeleton organization
(GO:0000226)
Microtubule organizing center
(GO:0005815)
Mitotic cell cycle
(GO:0000278)
Mitotic centrosome separation
(GO:0007100)
Mitotic spindle
(GO:0072686)
Mitotic spindle organization
(GO:0007052)
Mitotic spindle pole
(GO:0097431)
Molecular function activator activity
(GO:0140677)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of protein binding
(GO:0032091)
Negative regulation of spindle checkpoint
(GO:0090233)
Neuron projection extension
(GO:1990138)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Peptidyl-serine phosphorylation
(GO:0018105)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of mitochondrial fission
(GO:0090141)
Positive regulation of oocyte maturation
(GO:1900195)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Postsynaptic density
(GO:0014069)
Pronucleus
(GO:0045120)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein localization to centrosome
(GO:0071539)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of cytokinesis
(GO:0032465)
Regulation of protein stability
(GO:0031647)
Response to wounding
(GO:0009611)
Spindle assembly involved in female meiosis i
(GO:0007057)
Spindle microtubule
(GO:0005876)
Spindle midzone
(GO:0051233)
Spindle organization
(GO:0007051)
Spindle pole
(GO:0000922)
Spindle pole centrosome
(GO:0031616)
Transferase activity
(GO:0016740)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

AURKA_MOUSE

Genular Protein ID: 2331015211

Symbol: AURKA_MOUSE

Name: N/A

UniProtKB Accession Codes:

P97477 O35624 Q8C3H8 Q91YU4

Database IDs:

Citations:

PubMed ID: 9245792

Title: A novel mammalian, mitotic spindle-associated kinase is related to yeast and fly chromosome segregation regulators.

PubMed ID: 9245792

DOI: 10.1083/jcb.138.3.643

PubMed ID: 9205101

Title: ayk1, a novel mammalian gene related to Drosophila aurora centrosome separation kinase, is specifically expressed during meiosis.

PubMed ID: 9205101

DOI: 10.1038/sj.onc.1201144

PubMed ID: 9514916

Title: cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2.

PubMed ID: 9514916

DOI: 10.1006/bbrc.1998.8250

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15793587

Title: Chfr is required for tumor suppression and Aurora A regulation.

PubMed ID: 15793587

DOI: 10.1038/ng1538

PubMed ID: 19075002

Title: Aurora-A kinase is essential for bipolar spindle formation and early development.

PubMed ID: 19075002

DOI: 10.1128/mcb.01062-08

PubMed ID: 19668197

Title: An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics.

PubMed ID: 19668197

DOI: 10.1038/ncb1919

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20643351

Title: Pitchfork regulates primary cilia disassembly and left-right asymmetry.

PubMed ID: 20643351

DOI: 10.1016/j.devcel.2010.06.005

PubMed ID: 22306998

Title: Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest.

PubMed ID: 22306998

DOI: 10.4161/cc.11.4.19171

PubMed ID: 22753416

Title: Furry protein promotes Aurora A-mediated polo-like kinase 1 activation.

PubMed ID: 22753416

DOI: 10.1074/jbc.m112.378968

PubMed ID: 18579375

Title: Discovery of an Aurora kinase inhibitor through site-specific dynamic combinatorial chemistry.

PubMed ID: 18579375

DOI: 10.1016/j.bmcl.2008.06.011

PubMed ID: 18678489

Title: Discovery of a potent and selective aurora kinase inhibitor.

PubMed ID: 18678489

DOI: 10.1016/j.bmcl.2008.07.073

PubMed ID: 23807208

Title: The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis.

PubMed ID: 23807208

DOI: 10.1007/s00018-013-1401-6

PubMed ID: 27753540

Title: Bcl2l10, a new Tpx2 binding partner, is a master regulator of Aurora kinase A in mouse oocytes.

PubMed ID: 27753540

DOI: 10.1080/15384101.2016.1243630

Sequence Information:

Length: 395
Mass: 44772
Checksum: 26B6B65105A1A812
Sequence:

MDRCKENCVS RPVKTTVPFG PKRVLVTEQI PSQNLGSASS GQAQRVLCPS NSQRVPSQAQ 
KLGAGQKPAP KQLPAASVPR PVSRLNNPQK NEQPAASGND SEKEQASLQK TEDTKKRQWT 
LEDFDIGRPL GKGKFGNVYL ARERQSKFIL ALKVLFKTQL EKANVEHQLR REVEIQSHLR 
HPNILRLYGY FHDATRVYLI LEYAPLGTVY RELQKLSKFD EQRTATYITE LANALSYCHS 
KRVIHRDIKP ENLLLGSNGE LKIADFGWSV HAPSSRRTTM CGTLDYLPPE MIEGRMHDEK 
VDLWSLGVLC YEFLVGMPPF EAHTYQETYR RISRVEFTFP DFVTEGARDL ISRLLKHNAS 
QRLTLAEVLE HPWIKANSSK PPTGHTSKEP TSKSS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Aurka

Associated with

Other Information

A novel mammalian, mitotic spindle-associated kinase is related to yeast and fly chromosome segregation regulators. PubMed ID: 9245792

ayk1, a novel mammalian gene related to Drosophila aurora centrosome separation kinase, is specifically expressed during meiosis. PubMed ID: 9205101

cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2. PubMed ID: 9514916

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Chfr is required for tumor suppression and Aurora A regulation. PubMed ID: 15793587

Aurora-A kinase is essential for bipolar spindle formation and early development. PubMed ID: 19075002

An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics. PubMed ID: 19668197

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Pitchfork regulates primary cilia disassembly and left-right asymmetry. PubMed ID: 20643351

Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest. PubMed ID: 22306998

Furry protein promotes Aurora A-mediated polo-like kinase 1 activation. PubMed ID: 22753416

Discovery of an Aurora kinase inhibitor through site-specific dynamic combinatorial chemistry. PubMed ID: 18579375

Discovery of a potent and selective aurora kinase inhibitor. PubMed ID: 18678489

The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis. PubMed ID: 23807208

Bcl2l10, a new Tpx2 binding partner, is a master regulator of Aurora kinase A in mouse oocytes. PubMed ID: 27753540